A85-Mycolyl-transferase
Relationship
Comment
This family contains Antigen85 responsible for high affinity of mycobacteria for fibronectin. Proteins of the antigen 85 possess a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity. Mycobacterium tuberculosis MPT51 (FbpC1) is a non-catalytic alpha/beta hydrolases member of this family. This family corresponds to a subset of the the Carbohydrate Esterase family CE1 in CAZy - Carbohydrate-Active enZYmes database (CE_1)Database
Interpro : IPR000801 Esterase_put
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00756 Esterase
Prints : No Print
EC Number : 2.3.1.20 || 2.3.1.122
References (5)
| Title : Mycoloyltransferases: A large and major family of enzymes shaping the cell envelope of Corynebacteriales - Dautin_2017_Biochim.Biophys.Acta_1861_3581 |
| Author(s) : Dautin N , de Sousa-D'Auria C , Constantinesco-Becker F , Labarre C , Oberto J , de la Sierra-Gallay IL , Dietrich C , Issa H , Houssin C , Bayan N |
| Ref : Biochimica & Biophysica Acta , 1861 :3581 , 2017 |
| Abstract : Dautin_2017_Biochim.Biophys.Acta_1861_3581 |
| ESTHER : Dautin_2017_Biochim.Biophys.Acta_1861_3581 |
| PubMedSearch : Dautin_2017_Biochim.Biophys.Acta_1861_3581 |
| PubMedID: 27345499 |
| Title : The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha\/beta hydrolases - Wilson_2004_J.Mol.Biol_335_519 |
| Author(s) : Wilson RA , Maughan WN , Kremer L , Besra GS , Futterer K |
| Ref : Journal of Molecular Biology , 335 :519 , 2004 |
| Abstract : Wilson_2004_J.Mol.Biol_335_519 |
| ESTHER : Wilson_2004_J.Mol.Biol_335_519 |
| PubMedSearch : Wilson_2004_J.Mol.Biol_335_519 |
| PubMedID: 14672660 |
| Gene_locus related to this paper: myctu-mpt51 |
| Title : Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity - Ronning_2004_J.Biol.Chem_279_36771 |
| Author(s) : Ronning DR , Vissa V , Besra GS , Belisle JT , Sacchettini JC |
| Ref : Journal of Biological Chemistry , 279 :36771 , 2004 |
| Abstract : Ronning_2004_J.Biol.Chem_279_36771 |
| ESTHER : Ronning_2004_J.Biol.Chem_279_36771 |
| PubMedSearch : Ronning_2004_J.Biol.Chem_279_36771 |
| PubMedID: 15192106 |
| Gene_locus related to this paper: myctu-a85a , myctu-a85c |
| Title : An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase. - Anderson_2001_J.Mol.Biol_307_671 |
| Author(s) : Anderson DH , Harth G , Horwitz MA , Eisenberg D |
| Ref : Journal of Molecular Biology , 307 :671\ , 2001 |
| Abstract : Anderson_2001_J.Mol.Biol_307_671 |
| ESTHER : Anderson_2001_J.Mol.Biol_307_671 |
| PubMedSearch : Anderson_2001_J.Mol.Biol_307_671 |
| PubMedID: 11254389 |
| Gene_locus related to this paper: myctu-a85b |
| Title : Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines - Ronning_2000_Nat.Struct.Biol_7_141 |
| Author(s) : Ronning DR , Klabunde T , Besra GS , Vissa VD , Belisle JT , Sacchettini JC |
| Ref : Nat Struct Biol , 7 :141 , 2000 |
| Abstract : Ronning_2000_Nat.Struct.Biol_7_141 |
| ESTHER : Ronning_2000_Nat.Struct.Biol_7_141 |
| PubMedSearch : Ronning_2000_Nat.Struct.Biol_7_141 |
| PubMedID: 10655617 |
| Gene_locus related to this paper: myctu-a85c |
Structures (26)
Genes Proteins in A85-Mycolyl-transferase family (194)
Fragments of genes in A85-Mycolyl-transferase family (8)
Structures in A85-Mycolyl-transferase family (26)Substrates in A85-Mycolyl-transferase family (4)
Inhibitors in A85-Mycolyl-transferase family (19)