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Family Report for: Acidic_Lipase

Acidic_Lipase



Relationship
Block X
Parent Family : Abhydrolase_6

Comment
This entry represents a family of eukaryotic lipases, including gastric triacylglycerol lipase (LIPF) lysosomal acid lipase (LIPA) and LIPJ, LIPK, LIPM, LIPN. Mutations in LIPA cause Wolman disease, Cholesterol Ester Storage Disease, CESD and mutation in LIPN causes Late-Onset Form of Autosomal-Recessive Congenital Ichthyosis
2 Disease(s)


Database
Sequences
Interpro
|
IPR039097 (Gastric triacylglycerol lipase), IPR025483 (Lipase, eukaryotic Lipase_euk), IPR000734 (Lipase), IPR006693 (AB-hydrolase-associated lipase region)
PIRSF
|
Pdoc
|
PFam
|
PF04083 (Abhydro_lipase)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
17 more
    Title: Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo)
    Holmes RS, Cox LA, Vandeberg JL
    Ref: Comparative Biochemistry & Physiology Part D Genomics Proteomics, 5:217, 2010 : PubMed

            

    Title: Gastric lipase: crystal structure and activity
    Canaan S, Roussel A, Verger R, Cambillau C
    Ref: Biochimica & Biophysica Acta, 1441:197, 1999 : PubMed

            

    Title: Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest
    Roussel A, Canaan S, Egloff MP, Riviere M, Dupuis L, Verger R, Cambillau C
    Ref: Journal of Biological Chemistry, 274:16995, 1999 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Acidic_Lipase family (3)

Genes Proteins in Acidic_Lipase family (672)

Fragments of genes in Acidic_Lipase family (83)

Substrates of some enzymes in the Acidic_Lipase family (38)

Inhibitors of some enzymes in the Acidic_Lipase family (15)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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