FSH1
Comment
Family of serine hydrolase 1(FSH1). Previously: Domain of unknown function (DUF341). Contains human-OVCA2 Human Candidate tumor suppressor in ovarian cancer and yeast-FSH3 regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae, may be involved in folate metabolism. Contains also the gene (dfr1) encoding FSH1 linked to a domain corresponding to dihydrofolate reductase (DHFR) in Schizosaccharomyces pombe. Fsh1p was identified as a lysophospholipase that specifically acts on lysophosphatidylserine (LPS) and impacts the lipid homeostasis in S. cerevisiae. Contains also Aspergillus terreus esterase LovG, which catalyzes the release of covalently bound dihydromonacolin L from LovB during lovastatin biosynthesis. OVCA2 has a strong preference for long-chain alkyl ester substrates (>10-carbons) and high selectivity against a variety of short, branched, and substituted estersDatabase
Interpro : IPR005645 Serine hydrolase FSH FSH_dom
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF03959 FSH1
Prints : No Print
EC Number : No EC Number
References (11)
| Title : FSH1 encodes lysophospholipase activity in Saccharomyces cerevisiae - Ramachandran_2021_Biotechnol.Lett_43_279 |
| Author(s) : Ramachandran G , Chidambaram R , Nachiappan V |
| Ref : Biotechnol Lett , 43 :279 , 2021 |
| Abstract : Ramachandran_2021_Biotechnol.Lett_43_279 |
| ESTHER : Ramachandran_2021_Biotechnol.Lett_43_279 |
| PubMedSearch : Ramachandran_2021_Biotechnol.Lett_43_279 |
| PubMedID: 32920715 |
| Gene_locus related to this paper: yeast-FSH1 |
| Title : Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae - Bun_2020_PLoS.One_15_e0230166 |
| Author(s) : Bun JS , Slack MD , Schemenauer DE , Johnson RJ |
| Ref : PLoS ONE , 15 :e0230166 , 2020 |
| Abstract : Bun_2020_PLoS.One_15_e0230166 |
| ESTHER : Bun_2020_PLoS.One_15_e0230166 |
| PubMedSearch : Bun_2020_PLoS.One_15_e0230166 |
| PubMedID: 32182256 |
| Gene_locus related to this paper: human-OVCA2 , yeast-FSH1 |
| Title : FSH1 overexpression triggers apoptosis in Saccharomyces cerevisiae - Gowsalya_2019_Antonie.Van.Leeuwenhoek_112_1775 |
| Author(s) : Gowsalya R , Ravi C , Arul M , Nachiappan V |
| Ref : Antonie Van Leeuwenhoek , 112 :1775 , 2019 |
| Abstract : Gowsalya_2019_Antonie.Van.Leeuwenhoek_112_1775 |
| ESTHER : Gowsalya_2019_Antonie.Van.Leeuwenhoek_112_1775 |
| PubMedSearch : Gowsalya_2019_Antonie.Van.Leeuwenhoek_112_1775 |
| PubMedID: 31363875 |
| Gene_locus related to this paper: yeast-FSH1 |
| Title : FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae - Gowsalya_2019_FEMS.Yeast.Res_19_ |
| Author(s) : Gowsalya R , Ravi C , Kannan M , Nachiappan V |
| Ref : FEMS Yeast Res , 19 : , 2019 |
| Abstract : Gowsalya_2019_FEMS.Yeast.Res_19_ |
| ESTHER : Gowsalya_2019_FEMS.Yeast.Res_19_ |
| PubMedSearch : Gowsalya_2019_FEMS.Yeast.Res_19_ |
| PubMedID: 30776074 |
| Gene_locus related to this paper: yeast-FSH3 |
| Title : FSH1 regulates the phenotype and pathogenicity of the pathogenic dermatophyte Microsporum canis - Zhang_2019_Int.J.Mol.Med_44_2047 |
| Author(s) : Zhang F , Tan C , Xu Y , Yang G |
| Ref : Int J Mol Med , 44 :2047 , 2019 |
| Abstract : Zhang_2019_Int.J.Mol.Med_44_2047 |
| ESTHER : Zhang_2019_Int.J.Mol.Med_44_2047 |
| PubMedSearch : Zhang_2019_Int.J.Mol.Med_44_2047 |
| PubMedID: 31573050 |
| Gene_locus related to this paper: artot-a0a516ux40 |
| Title : LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis - |
| Author(s) : Xu W , Chooi YH , Choi JW , Li S , Vederas JC , Da Silva NA , Tang Y |
| Ref : Angew Chem Int Ed Engl , 52 :6472 , 2013 |
| PubMedID: 23653178 |
| Gene_locus related to this paper: asptn-LOVG |
| Title : Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY - Azizi_2006_Cancer.Lett_241_235 |
| Author(s) : Azizi AA , Gelpi E , Yang JW , Rupp B , Godwin AK , Slater C , Slavc I , Lubec G |
| Ref : Cancer Letters , 241 :235 , 2006 |
| Abstract : Azizi_2006_Cancer.Lett_241_235 |
| ESTHER : Azizi_2006_Cancer.Lett_241_235 |
| PubMedSearch : Azizi_2006_Cancer.Lett_241_235 |
| PubMedID: 16368187 |
| Gene_locus related to this paper: human-OVCA2 |
| Title : Crystal structure of yeast YHR049W\/FSH1, a member of the serine hydrolase family - Quevillon-Cheruel_2005_Protein.Sci_14_1350 |
| Author(s) : Quevillon-Cheruel S , Leulliot N , Graille M , Hervouet N , Coste F , Benedetti H , Zelwer C , Janin J , van Tilbeurgh H |
| Ref : Protein Science , 14 :1350 , 2005 |
| Abstract : Quevillon-Cheruel_2005_Protein.Sci_14_1350 |
| ESTHER : Quevillon-Cheruel_2005_Protein.Sci_14_1350 |
| PubMedSearch : Quevillon-Cheruel_2005_Protein.Sci_14_1350 |
| PubMedID: 15802654 |
| Gene_locus related to this paper: yeast-FSH1 |
| Title : Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae - Zaim_2005_J.Biol.Chem_280_28 |
| Author(s) : Zaim J , Speina E , Kierzek AM |
| Ref : Journal of Biological Chemistry , 280 :28 , 2005 |
| Abstract : Zaim_2005_J.Biol.Chem_280_28 |
| ESTHER : Zaim_2005_J.Biol.Chem_280_28 |
| PubMedSearch : Zaim_2005_J.Biol.Chem_280_28 |
| PubMedID: 15494396 |
| Gene_locus related to this paper: yeast-FSH3 |
| Title : OVCA2 is downregulated and degraded during retinoid-induced apoptosis - Prowse_2002_Int.J.Cancer_99_185 |
| Author(s) : Prowse AH , Vanderveer L , Milling SW , Pan ZZ , Dunbrack RL , Xu XX , Godwin AK |
| Ref : International Journal of Cancer , 99 :185 , 2002 |
| Abstract : Prowse_2002_Int.J.Cancer_99_185 |
| ESTHER : Prowse_2002_Int.J.Cancer_99_185 |
| PubMedSearch : Prowse_2002_Int.J.Cancer_99_185 |
| PubMedID: 11979432 |
| Gene_locus related to this paper: human-OVCA2 |
| Title : Identification of two candidate tumor suppressor genes on chromosome 17p13.3 - Schultz_1996_Cancer.Res_56_1997 |
| Author(s) : Schultz DC , Vanderveer L , Berman DB , Hamilton TC , Wong AJ , Godwin AK |
| Ref : Cancer Research , 56 :1997 , 1996 |
| Abstract : Schultz_1996_Cancer.Res_56_1997 |
| ESTHER : Schultz_1996_Cancer.Res_56_1997 |
| PubMedSearch : Schultz_1996_Cancer.Res_56_1997 |
| PubMedID: 8616839 |
| Gene_locus related to this paper: human-OVCA2 |
Structures (1)
Genes Proteins in FSH1 family (123)
Fragments of genes in FSH1 family (19)
Structures in FSH1 family (1)Substrates in FSH1 family (1)
Inhibitors in FSH1 family (1)