Fusarinine_C_esterase_sidJ
Relationship
Comment
Grundlingern et al. show that Aspergillus fumigatus AFUA_3G03390 gene product, SidJ (aspfu-q4wf56) is involved in hydrolysis of siderophore fusarinine C. It is the first functionally characterized member of the family. Structure of siderophore esterase AfSidJ from Aspergillus fumigatus is described by Ecker et al.. A structure of a protein of unknown fucntion is also available (2Q0X) Merritt et al. . However this protein is only representative of trypanosomatid members of this sequence family as these proteins lack some if not all of the catalytic triad residues. Fusarinine C is an intracellular siderophore (an iron-chelating compound that transports iron across membranes) that is crucial for virulence. The closely related siderophore triacetylfusarinine C is not hydrolysed by SidJ. Homologues of SidJ are found in plants and bacteria. (Not to be cofounded with SidJ Calmodulin-dependent glutamylase from Legionella pneumophila).Previously named DUF_1749Database
Interpro : IPR013744 Fusarinine C esterase sidJ DUF_1749
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF08538 DUF1749
Prints : No Print
EC Number : No EC Number
References (3)
| Title : Iron Scavenging in Aspergillus Species: Structural and Biochemical Insights into Fungal Siderophore Esterases - Ecker_2018_Angew.Chem.Int.Ed.Engl_57_14624 |
| Author(s) : Ecker F , Haas H , Groll M , Huber EM |
| Ref : Angew Chem Int Ed Engl , 57 :14624 , 2018 |
| Abstract : Ecker_2018_Angew.Chem.Int.Ed.Engl_57_14624 |
| ESTHER : Ecker_2018_Angew.Chem.Int.Ed.Engl_57_14624 |
| PubMedSearch : Ecker_2018_Angew.Chem.Int.Ed.Engl_57_14624 |
| PubMedID: 30070018 |
| Gene_locus related to this paper: aspfu-q4wf29 , emeni-AnEstB , emeni-q5av79 , aspfu-q4wf56 |
| Title : Aspergillus fumigatus SidJ Mediates Intracellular Siderophore Hydrolysis - Grundlinger_2013_Appl.Environ.Microbiol_79_7534 |
| Author(s) : Grundlinger M , Gsaller F , Schrettl M , Lindner H , Haas H |
| Ref : Applied Environmental Microbiology , 79 :7534 , 2013 |
| Abstract : Grundlinger_2013_Appl.Environ.Microbiol_79_7534 |
| ESTHER : Grundlinger_2013_Appl.Environ.Microbiol_79_7534 |
| PubMedSearch : Grundlinger_2013_Appl.Environ.Microbiol_79_7534 |
| PubMedID: 24038704 |
| Gene_locus related to this paper: aspfu-q4wf56 |
| Title : Structure of a Trypanosoma brucei alpha\/beta-hydrolase fold protein with unknown function - Merritt_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_474 |
| Author(s) : Merritt EA , Holmes M , Buckner FS , Van Voorhis WC , Quartly E , Phizicky EM , Lauricella A , Luft J , DeTitta G , Neely H , Zucker F , Hol WG |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 64 :474 , 2008 |
| Abstract : Merritt_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_474 |
| ESTHER : Merritt_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_474 |
| PubMedSearch : Merritt_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_474 |
| PubMedID: 18540054 |
| Gene_locus related to this paper: tryb2-q389w3 |
Structures (2)
Genes Proteins in Fusarinine_C_esterase_sidJ family (104)
Fragments of genes in Fusarinine_C_esterase_sidJ family (4)
Structures in Fusarinine_C_esterase_sidJ family (2)Substrates in Fusarinine_C_esterase_sidJ family (1)
No Inhibitor