Hydrolase_RBBP9_YdeN
Relationship
Comment
Retinoblastoma binding protein 9 is an aminopeptidase with a preference for removing aromatic amino acids in human cells (Tang et al.). Ser_hydrolase.Hydrolase_RBBP9/YdeN. Protein of unknown function DUF1234 (old Duf_1234). This family contains Bacillus subtilis yden protein and human retinoblastoma-binding protein 9 (RBBP-9) required for pancreatic neoplasia. Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family.Database
Interpro : IPR010662 Putative hydrolase RBBP9\/YdeN DUF1234
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF06821 Ser_hydrolase
Prints : No Print
EC Number : No EC Number
References (16)
| Title : Mechanism-based traps enable protease and hydrolase substrate discovery - Tang_2022_Nature_602_701 |
| Author(s) : Tang S , Beattie AT , Kafkova L , Petris G , Huguenin-Dezot N , Fiedler M , Freeman M , Chin JW |
| Ref : Nature , 602 :701 , 2022 |
| Abstract : Tang_2022_Nature_602_701 |
| ESTHER : Tang_2022_Nature_602_701 |
| PubMedSearch : Tang_2022_Nature_602_701 |
| PubMedID: 35173328 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Application of the RBBP9 Serine Hydrolase Inhibitor, ML114, Decouples Human Pluripotent Stem Cell Proliferation and Differentiation - Lim_2020_Int.J.Mol.Sci_21_8983 |
| Author(s) : Lim S , Shparberg RA , Coorssen JR , O'Connor MD |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : Lim_2020_Int.J.Mol.Sci_21_8983 |
| ESTHER : Lim_2020_Int.J.Mol.Sci_21_8983 |
| PubMedSearch : Lim_2020_Int.J.Mol.Sci_21_8983 |
| PubMedID: 33256189 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Chemoproteomic Identification of Serine Hydrolase RBBP9 as a Valacyclovir-Activating Enzyme - Shenoy_2020_Mol.Pharm_17_1706 |
| Author(s) : Shenoy VM , Thompson BR , Shi J , Zhu HJ , Smith DE , Amidon GL |
| Ref : Mol Pharm , 17 :1706 , 2020 |
| Abstract : Shenoy_2020_Mol.Pharm_17_1706 |
| ESTHER : Shenoy_2020_Mol.Pharm_17_1706 |
| PubMedSearch : Shenoy_2020_Mol.Pharm_17_1706 |
| PubMedID: 32196348 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2 - Adachi_2020_Int.Immunol_32_637 |
| Author(s) : Adachi T , Yasuda K , Muto T , Serada S , Yoshimoto T , Ishii KJ , Kuroda E , Araki K , Ohmuraya M , Naka T , Nakanishi K |
| Ref : Int Immunol , 32 :637 , 2020 |
| Abstract : Adachi_2020_Int.Immunol_32_637 |
| ESTHER : Adachi_2020_Int.Immunol_32_637 |
| PubMedSearch : Adachi_2020_Int.Immunol_32_637 |
| PubMedID: 32484881 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers - Vorobiev_2012_Protein.Pept.Lett_19_194 |
| Author(s) : Vorobiev SM , Huang YJ , Seetharaman J , Xiao R , Acton TB , Montelione GT , Tong L |
| Ref : Protein Pept Lett , 19 :194 , 2012 |
| Abstract : Vorobiev_2012_Protein.Pept.Lett_19_194 |
| ESTHER : Vorobiev_2012_Protein.Pept.Lett_19_194 |
| PubMedSearch : Vorobiev_2012_Protein.Pept.Lett_19_194 |
| PubMedID: 21933118 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9 - Liu_2012_Chembiochem_13_2082 |
| Author(s) : Liu X , Dix M , Speers AE , Bachovchin DA , Zuhl AM , Cravatt BF , Kodadek TJ |
| Ref : Chembiochem , 13 :2082 , 2012 |
| Abstract : Liu_2012_Chembiochem_13_2082 |
| ESTHER : Liu_2012_Chembiochem_13_2082 |
| PubMedSearch : Liu_2012_Chembiochem_13_2082 |
| PubMedID: 22907802 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis - Nachmany_2012_Dis.Markers_32_211 |
| Author(s) : Nachmany H , Wald S , Abekasis M , Bulvik S , Weil M |
| Ref : Dis Markers , 32 :211 , 2012 |
| Abstract : Nachmany_2012_Dis.Markers_32_211 |
| ESTHER : Nachmany_2012_Dis.Markers_32_211 |
| PubMedSearch : Nachmany_2012_Dis.Markers_32_211 |
| PubMedID: 22430187 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance - O'Connor_2011_Exp.Hematol_39_866 |
| Author(s) : O'Connor MD , Wederell E , Robertson G , Delaney A , Morozova O , Poon SS , Yap D , Fee J , Zhao Y , McDonald H , Zeng T , Hirst M , Marra MA , Aparicio SA , Eaves CJ |
| Ref : Experimental Hematology , 39 :866 , 2011 |
| Abstract : O'Connor_2011_Exp.Hematol_39_866 |
| ESTHER : O'Connor_2011_Exp.Hematol_39_866 |
| PubMedSearch : O'Connor_2011_Exp.Hematol_39_866 |
| PubMedID: 21689726 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia - Shields_2010_Proc.Natl.Acad.Sci.U.S.A_107_2189 |
| Author(s) : Shields DJ , Niessen S , Murphy EA , Mielgo A , Desgrosellier JS , Lau SK , Barnes LA , Lesperance J , Bouvet M , Tarin D , Cravatt BF , Cheresh DA |
| Ref : Proc Natl Acad Sci U S A , 107 :2189 , 2010 |
| Abstract : Shields_2010_Proc.Natl.Acad.Sci.U.S.A_107_2189 |
| ESTHER : Shields_2010_Proc.Natl.Acad.Sci.U.S.A_107_2189 |
| PubMedSearch : Shields_2010_Proc.Natl.Acad.Sci.U.S.A_107_2189 |
| PubMedID: 20080647 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) - Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 |
| Author(s) : Bachovchin DA , Wolfe MR , Masuda K , Brown SJ , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Rosen H , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2254 , 2010 |
| Abstract : Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 |
| ESTHER : Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 |
| PubMedSearch : Bachovchin_2010_Bioorg.Med.Chem.Lett_20_2254 |
| PubMedID: 20207142 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Probe Report for RBBP9 Inhibitors - Probe 2 - Bachovchin_2010_Probe.Report.1__ |
| Author(s) : Bachovchin DA , Speers AE , Brown SJ , Cravatt BF , Spicer T , Mercer BA , Ferguson J , Hodder P , Rosen HR |
| Ref : Probe Report , : , 2010 |
| Abstract : Bachovchin_2010_Probe.Report.1__ |
| ESTHER : Bachovchin_2010_Probe.Report.1__ |
| PubMedSearch : Bachovchin_2010_Probe.Report.1__ |
| PubMedID: 21433382 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Probe Report for RBBP9 Inhibitors - Probe 1 - Brown_2010_Probe.Report__ |
| Author(s) : Brown SJ , Bachovchin DA , Cravatt BF , Fernandez-Vega V , Spicer T , Mercer BA , Hodder P , Rosen HR |
| Ref : Probe Report , : , 2010 |
| Abstract : Brown_2010_Probe.Report__ |
| ESTHER : Brown_2010_Probe.Report__ |
| PubMedSearch : Brown_2010_Probe.Report__ |
| PubMedID: 21433353 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Crystal structure of human retinoblastoma binding protein 9 - |
| Author(s) : Vorobiev SM , Su M , Seetharaman J , Huang YJ , Chen CX , Maglaqui M , Janjua H , Proudfoot M , Yakunin A , Xiao R , Acton TB , Montelione GT , Tong L |
| Ref : Proteins , 74 :526 , 2009 |
| PubMedID: 19004028 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo - Cassie_2006_Carcinogenesis_27_465 |
| Author(s) : Cassie S , Koturbash I , Hudson D , Baker M , Ilnytskyy Y , Rodriguez-Juarez R , Weber E , Kovalchuk O |
| Ref : Carcinogenesis , 27 :465 , 2006 |
| Abstract : Cassie_2006_Carcinogenesis_27_465 |
| ESTHER : Cassie_2006_Carcinogenesis_27_465 |
| PubMedSearch : Cassie_2006_Carcinogenesis_27_465 |
| PubMedID: 16272168 |
| Gene_locus related to this paper: human-RBBP9 |
| Title : Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution - Janda_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1101 |
| Author(s) : Janda I , Devedjiev Y , Cooper D , Chruszcz M , Derewenda U , Gabrys A , Minor W , Joachimiak A , Derewenda ZS |
| Ref : Acta Crystallographica D Biol Crystallogr , 60 :1101 , 2004 |
| Abstract : Janda_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1101 |
| ESTHER : Janda_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1101 |
| PubMedSearch : Janda_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1101 |
| PubMedID: 15159570 |
| Gene_locus related to this paper: bacsu-YDEN |
| Title : A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability - Woitach_1998_Nat.Genet_19_371 |
| Author(s) : Woitach JT , Zhang M , Niu CH , Thorgeirsson SS |
| Ref : Nat Genet , 19 :371 , 1998 |
| Abstract : Woitach_1998_Nat.Genet_19_371 |
| ESTHER : Woitach_1998_Nat.Genet_19_371 |
| PubMedSearch : Woitach_1998_Nat.Genet_19_371 |
| PubMedID: 9697699 |
| Gene_locus related to this paper: human-RBBP9 , ratno-rbbp9 |
Structures (4)
Genes Proteins in Hydrolase_RBBP9_YdeN family (102)
Fragments of genes in Hydrolase_RBBP9_YdeN family (2)
Structures in Hydrolase_RBBP9_YdeN family (4)No substrate
Inhibitors in Hydrolase_RBBP9_YdeN family (4)