Neurotactin
Relationship
Comment
Only the C-terminal part of Neurotactin is a member of the alpha/beta hydrolase family. The N-terminal part of Neurotactin has low complexity is desordered and is intracellular. Neurotactin is found only in arthropods
Neurotactin is only detected during cell proliferation and differentiation, and it is found mainly in neural tissue and also in mesoderm and imaginal discs. Neurotactin has a large cytoplasmic domain rich in charged residues and an extracellular domain similar to cholinesterase that lacks the active site serine required for esterase activity. Amalgam is a ligand for the transmembrane receptor neurotactin and is required for neurotactin-mediated cell adhesion and axon fasciculation in Drosophila. Mutants of neurotactin revealed specific requirements for neurotactin during axon outgrowth, fasciculation, and guidance. Database
Interpro : IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : No Pdoc
Pfam : PF00135 COesterase
Prints : No Print
EC Number : No EC Number
References (10)
| Title : The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties - Zeev-Ben-Mordehai_2009_Biophys.J_97_2316 |
| Author(s) : Zeev-Ben-Mordehai T , Mylonas E , Paz A , Peleg Y , Toker L , Silman I , Svergun DI , Sussman JL |
| Ref : Biophysical Journal , 97 :2316 , 2009 |
| Abstract : Zeev-Ben-Mordehai_2009_Biophys.J_97_2316 |
| ESTHER : Zeev-Ben-Mordehai_2009_Biophys.J_97_2316 |
| PubMedSearch : Zeev-Ben-Mordehai_2009_Biophys.J_97_2316 |
| PubMedID: 19843464 |
| Title : Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization - Zeev-Ben-Mordehai_2009_Protein.Expr.Purif_63_147 |
| Author(s) : Zeev-Ben-Mordehai T , Paz A , Peleg Y , Toker L , Wolf SG , Rydberg EH , Sussman JL , Silman I |
| Ref : Protein Expr Purif , 63 :147 , 2009 |
| Abstract : Zeev-Ben-Mordehai_2009_Protein.Expr.Purif_63_147 |
| ESTHER : Zeev-Ben-Mordehai_2009_Protein.Expr.Purif_63_147 |
| PubMedSearch : Zeev-Ben-Mordehai_2009_Protein.Expr.Purif_63_147 |
| PubMedID: 18938249 |
| Title : Developmental architecture of adult-specific lineages in the ventral CNS of Drosophila - Truman_2004_Development_131_5167 |
| Author(s) : Truman JW , Schuppe H , Shepherd D , Williams DW |
| Ref : Development , 131 :5167 , 2004 |
| Abstract : Truman_2004_Development_131_5167 |
| ESTHER : Truman_2004_Development_131_5167 |
| PubMedSearch : Truman_2004_Development_131_5167 |
| PubMedID: 15459108 |
| Title : Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding - Liebl_2003_Development_130_3217 |
| Author(s) : Liebl EC , Rowe RG , Forsthoefel DJ , Stammler AL , Schmidt ER , Turski M , Seeger MA |
| Ref : Development , 130 :3217 , 2003 |
| Abstract : Liebl_2003_Development_130_3217 |
| ESTHER : Liebl_2003_Development_130_3217 |
| PubMedSearch : Liebl_2003_Development_130_3217 |
| PubMedID: 12783792 |
| Title : Amalgam is a ligand for the transmembrane receptor neurotactin and is required for neurotactin-mediated cell adhesion and axon fasciculation in Drosophila - Fremion_2000_EMBO.J_19_4463 |
| Author(s) : Fremion F , Darboux I , Diano M , Hipeau-Jacquotte R , Seeger MA , Piovant M |
| Ref : EMBO Journal , 19 :4463 , 2000 |
| Abstract : Fremion_2000_EMBO.J_19_4463 |
| ESTHER : Fremion_2000_EMBO.J_19_4463 |
| PubMedSearch : Fremion_2000_EMBO.J_19_4463 |
| PubMedID: 10970840 |
| Gene_locus related to this paper: drome-nrtac |
| Title : Neurotactin functions in concert with other identified CAMs in growth cone guidance in Drosophila - Speicher_1998_Neuron_20_221 |
| Author(s) : Speicher S , Garci-Alonso L , Carmena A , Martin-Bermudo MD , de la Escalera S , Jimenez F |
| Ref : Neuron , 20 :221 , 1998 |
| Abstract : Speicher_1998_Neuron_20_221 |
| ESTHER : Speicher_1998_Neuron_20_221 |
| PubMedSearch : Speicher_1998_Neuron_20_221 |
| PubMedID: 9491984 |
| Title : The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties - Darboux_1996_EMBO.J_15_4835 |
| Author(s) : Darboux I , Barthalay Y , Piovant M , Hipeau-Jacquotte R |
| Ref : EMBO Journal , 15 :4835 , 1996 |
| Abstract : Darboux_1996_EMBO.J_15_4835 |
| ESTHER : Darboux_1996_EMBO.J_15_4835 |
| PubMedSearch : Darboux_1996_EMBO.J_15_4835 |
| PubMedID: 8890157 |
| Title : Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases - de la Escalera_1990_EMBO.J_9_3593 |
| Author(s) : de la Escalera S , Bockamp EO , Moya F , Piovant M , Jimenez F |
| Ref : EMBO Journal , 9 :3593 , 1990 |
| Abstract : de la Escalera_1990_EMBO.J_9_3593 |
| ESTHER : de la Escalera_1990_EMBO.J_9_3593 |
| PubMedSearch : de la Escalera_1990_EMBO.J_9_3593 |
| PubMedID: 2120047 |
| Gene_locus related to this paper: drome-nrtac |
| Title : Drosophila neurotactin mediates heterophilic cell adhesion - Barthalay_1990_EMBO.J_9_3603 |
| Author(s) : Barthalay Y , Hipeau-Jacquotte R , de la Escalera S , Jimenez F , Piovant M |
| Ref : EMBO Journal , 9 :3603 , 1990 |
| Abstract : Barthalay_1990_EMBO.J_9_3603 |
| ESTHER : Barthalay_1990_EMBO.J_9_3603 |
| PubMedSearch : Barthalay_1990_EMBO.J_9_3603 |
| PubMedID: 2120048 |
| Gene_locus related to this paper: drome-nrtac |
| Title : Drosophila neurotactin, a surface glycoprotein with homology to serine esterases, is dynamically expressed during embryogenesis - Hortsch_1990_Development_1100_1327 |
| Author(s) : Hortsch M , Patel NH , Bieber AJ , Traquina ZR , Goodman CS |
| Ref : Development , 110 (4) :1327 , 1990 |
| Abstract : Hortsch_1990_Development_1100_1327 |
| ESTHER : Hortsch_1990_Development_1100_1327 |
| PubMedSearch : Hortsch_1990_Development_1100_1327 |
| PubMedID: 2100266 |
| Gene_locus related to this paper: drome-nrtac |
No structure scheme yet for this family
Genes Proteins in Neurotactin family (60)
Fragments of genes in Neurotactin family (16)
No fragment of genesNo substrate
No Inhibitor