PC-sterol_acyltransferase
Relationship
Comment
Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT), Lecithin-cholesterol acyltransferase, belong to this family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport, respectively. Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease and familial LCAT deficiency.
LACT also known as phosphatidylcholine-sterol acyltransferase (EC), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases. This family correspond to group XV phospholipase A2. Phospholipid:diacylglycerol acyltransferase (PDAT)(2.3.1.158) is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid. A group of bacterial enzymes was extracted in a new family : Bacterial_EstLip_FamXIV Database
Interpro : IPR003386 Lecithin:cholesterol\/phospholipid:diacylglycerol acyltransferase LACT\/PDAT_acylTrfase
PIRSF : No PIRSF
Pdoc : PDOC00110
Pfam : PF02450 LACT-Lecithin:cholesterol acyltransferase LCAT
Prints : PR00821
EC Number : 2.3.1.43
References (8)
| Title : Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol - Manthei_2018_Elife_7_ |
| Author(s) : Manthei KA , Yang SM , Baljinnyam B , Chang L , Glukhova A , Yuan W , Freeman LA , Maloney DJ , Schwendeman A , Remaley AT , Jadhav A , Tesmer JJ |
| Ref : Elife , 7 : , 2018 |
| Abstract : Manthei_2018_Elife_7_ |
| ESTHER : Manthei_2018_Elife_7_ |
| PubMedSearch : Manthei_2018_Elife_7_ |
| PubMedID: 30479275 |
| Gene_locus related to this paper: human-LCAT |
| Title : A thermostable esterase from Thermoanaerobacter tengcongensis opening up a new family of bacterial lipolytic enzymes - Rao_2011_Biochim.Biophys.Acta_1814_1695 |
| Author(s) : Rao L , Xue Y , Zhou C , Tao J , Li G , Lu JR , Ma Y |
| Ref : Biochimica & Biophysica Acta , 1814 :1695 , 2011 |
| Abstract : Rao_2011_Biochim.Biophys.Acta_1814_1695 |
| ESTHER : Rao_2011_Biochim.Biophys.Acta_1814_1695 |
| PubMedSearch : Rao_2011_Biochim.Biophys.Acta_1814_1695 |
| PubMedID: 21907313 |
| Gene_locus related to this paper: thete-LIPA3 |
| Title : Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. - Zhang_2003_J.Biol.Chem_278_47145 |
| Author(s) : Zhang Q , Chieu HK , Low CP , Zhang S , Heng CK , Yang H |
| Ref : Journal of Biological Chemistry , 278 :47145\ , 2003 |
| Abstract : Zhang_2003_J.Biol.Chem_278_47145 |
| ESTHER : Zhang_2003_J.Biol.Chem_278_47145 |
| PubMedSearch : Zhang_2003_J.Biol.Chem_278_47145 |
| PubMedID: 12963726 |
| Gene_locus related to this paper: schpo-pdat |
| Title : Deficiency of lecithin:cholesterol acyltransferase due to compound heterozygosity of two novel mutations (Gly33Arg and 30 bp ins) in the LCAT gene - |
| Author(s) : Wiebusch H , Cullen P , Owen JS , Collins D , Sharp PS , Funke H , Assmann G |
| Ref : Hum Mol Genet , 4 :143 , 1995 |
| PubMedID: 7711728 |
| Gene_locus related to this paper: human-LCAT |
| Title : Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease - Funke_1993_J.Clin.Invest_91_677 |
| Author(s) : Funke H , von Eckardstein A , Pritchard PH , Hornby AE , Wiebusch H , Motti C , Hayden MR , Dachet C , Jacotot B , Gerdes U , Faergeman O , Albers JJ , Colleoni N , Catapano A , Frohlich J , Assmann G |
| Ref : J Clinical Investigation , 91 :677 , 1993 |
| Abstract : Funke_1993_J.Clin.Invest_91_677 |
| ESTHER : Funke_1993_J.Clin.Invest_91_677 |
| PubMedSearch : Funke_1993_J.Clin.Invest_91_677 |
| PubMedID: 8432868 |
| Gene_locus related to this paper: human-LCAT |
| Title : Lecithin cholesterol acyl transferase deficiency: molecular analysis of a mutated allele - Taramelli_1990_Hum.Genet_85_195 |
| Author(s) : Taramelli R , Pontoglio M , Candiani G , Ottolenghi S , Dieplinger H , Catapano A , Albers J , Vergani C , McLean J |
| Ref : Hum Genet , 85 :195 , 1990 |
| Abstract : Taramelli_1990_Hum.Genet_85_195 |
| ESTHER : Taramelli_1990_Hum.Genet_85_195 |
| PubMedSearch : Taramelli_1990_Hum.Genet_85_195 |
| PubMedID: 2370048 |
| Gene_locus related to this paper: human-LCAT |
| Title : Alpha-lecithin:cholesterol acyltransferase deficiency. Lack of both phospholipase A2 and acyltransferase activities characteristic of high density lipoprotein lecithin:cholesterol acyltransferase in fish eye disease - Holmquist_1987_Acta.Med.Scand_222_23 |
| Author(s) : Holmquist L , Carlson LA |
| Ref : Acta Med Scand , 222 :23 , 1987 |
| Abstract : Holmquist_1987_Acta.Med.Scand_222_23 |
| ESTHER : Holmquist_1987_Acta.Med.Scand_222_23 |
| PubMedSearch : Holmquist_1987_Acta.Med.Scand_222_23 |
| PubMedID: 3630775 |
| Gene_locus related to this paper: human-LCAT |
| Title : Inhibitory effect of normal high density lipoproteins on lecithin:cholesterol acyltransferase activity in fish eye disease plasma - Holmquist_1987_Acta.Med.Scand_222_15 |
| Author(s) : Holmquist L , Carlson LA |
| Ref : Acta Med Scand , 222 :15 , 1987 |
| Abstract : Holmquist_1987_Acta.Med.Scand_222_15 |
| ESTHER : Holmquist_1987_Acta.Med.Scand_222_15 |
| PubMedSearch : Holmquist_1987_Acta.Med.Scand_222_15 |
| PubMedID: 3630774 |
| Gene_locus related to this paper: human-LCAT |
Structures (14)
Genes Proteins in PC-sterol_acyltransferase family (92)
Fragments of genes in PC-sterol_acyltransferase family (28)
Structures in PC-sterol_acyltransferase family (14)Substrates in PC-sterol_acyltransferase family (5)
Inhibitors in PC-sterol_acyltransferase family (5)