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Family Report for: Proline_iminopeptidase

Proline_iminopeptidase



Relationship
Block X
Comment
This entry describes a subfamily of the alpha/beta fold family. This entry represents a of serine peptidase belonging to peptidase family S33 (clan SC). Family members include prolinases (Pro-Xaa dipeptidase, EC:3.4.13.18), prolyl aminopeptidases (EC:3.4.11.5), and a leucyl aminopeptidase. Prolyl aminopeptidase Pro_amnoPtase (S33 family) PROAMNOPTASE Pept_S33_TRI_F1 Pro_imino_pep_2. (Crystal structure of the proline iminopeptidase-related protein TTHA1809 from Thermus thermophilus HB8 (2YYS) showed that it lacks the active site serine and probably similar proteins play non enzymatic role in a few bacteria: Okai et al.2008)

Database
Sequences
Interpro
|
IPR005945 (Peptidase S33, Proline-specific peptidase), IPR005944 (Peptidase S33, Proline iminopeptidase), IPR002410 (Peptidase S33), IPR013595 (Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal Pept_S33_TAP-like_C)
PIRSF
|
Pdoc
|
PFam
|
PF12697 (Abhydrolase_6)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
6 more
    Title: Unusual extra space at the active site and high activity for acetylated hydroxyproline of prolyl aminopeptidase from Serratia marcescens
    Nakajima Y, Ito K, Sakata M, Xu Y, Nakashima K, Matsubara F, Hatakeyama S, Yoshimoto T
    Ref: Journal of Bacteriology, 188:1599, 2006 : PubMed

            

    Title: X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum
    Goettig P, Brandstetter H, Groll M, Gohring W, Konarev PV, Svergun DI, Huber R, Kim JS
    Ref: Journal of Biological Chemistry, 280:33387, 2005 : PubMed

            

    Title: Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism
    Goettig P, Groll M, Kim JS, Huber R, Brandstetter H
    Ref: EMBO Journal, 21:5343, 2002 : PubMed

            

Other Papers


Structure scheme for Proline_iminopeptidase

Structures in Proline_iminopeptidase family (24)

Genes Proteins in Proline_iminopeptidase family (1003)

Fragments of genes in Proline_iminopeptidase family (36)

Substrates of some enzymes in the Proline_iminopeptidase family (10)

Inhibitors of some enzymes in the Proline_iminopeptidase family (4)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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