Prolylcarboxypeptidase
Relationship
Comment
S28 peptidases in MEROPS database. These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase. In human the S28 family of peptidases consists of three enzymes, PRCP, TSSP and DPP7. DPP7 is also called dipeptidyl peptidase 2 and quiescent cell proline dipeptidase. TSSP is thymus-specific serine protease. PRCP is a lysosomal, serine carboxypeptidase that cleaves hydrophobic C-terminal amino acids adjacent to proline. In contrast, DPP7 is a serine dipeptidyl aminopeptidase that cleaves N-terminal amino acids adjacent to proline and is localized to intracellular vesiclesDatabase
Interpro : IPR008758 Peptidase_S28 , IPR042269 Serine carboxypeptidase S28, SKS domain
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF05577 Peptidase_S28
Prints : No Print
EC Number : 3.4.16.2
References (7)
| Title : Structural and time-resolved mechanistic investigations of protein hydrolysis by the acidic proline-specific endoprotease from Aspergillus niger - Pijning_2023_Protein.Sci__e4856 |
| Author(s) : Pijning T , Vujicic-zagar A , Laan JV , Jong RM , Ramirez-Palacios C , Vente A , Edens L , Dijkstra BW |
| Ref : Protein Science , :e4856 , 2023 |
| Abstract : Pijning_2023_Protein.Sci__e4856 |
| ESTHER : Pijning_2023_Protein.Sci__e4856 |
| PubMedSearch : Pijning_2023_Protein.Sci__e4856 |
| PubMedID: 38059672 |
| Gene_locus related to this paper: aspng-AnPEP |
| Title : The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis - Waumans_2015_Front.Immunol_6_387 |
| Author(s) : Waumans Y , Baerts L , Kehoe K , Lambeir AM , De Meester I |
| Ref : Front Immunol , 6 :387 , 2015 |
| Abstract : Waumans_2015_Front.Immunol_6_387 |
| ESTHER : Waumans_2015_Front.Immunol_6_387 |
| PubMedSearch : Waumans_2015_Front.Immunol_6_387 |
| PubMedID: 26300881 |
| Title : S28 peptidases: lessons from a seemingly 'dysfunctional' family of two - Kozarich_2010_BMC.Biol_8_87 |
| Author(s) : Kozarich JW |
| Ref : BMC Biol , 8 :87 , 2010 |
| Abstract : Kozarich_2010_BMC.Biol_8_87 |
| ESTHER : Kozarich_2010_BMC.Biol_8_87 |
| PubMedSearch : Kozarich_2010_BMC.Biol_8_87 |
| PubMedID: 20598110 |
| Title : Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase - Soisson_2010_BMC.Struct.Biol_10_16 |
| Author(s) : Soisson SM , Patel SB , Abeywickrema PD , Byrne NJ , Diehl RE , Hall DL , Ford RE , Reid JC , Rickert KW , Shipman JM , Sharma S , Lumb KJ |
| Ref : BMC Struct Biol , 10 :16 , 2010 |
| Abstract : Soisson_2010_BMC.Struct.Biol_10_16 |
| ESTHER : Soisson_2010_BMC.Struct.Biol_10_16 |
| PubMedSearch : Soisson_2010_BMC.Struct.Biol_10_16 |
| PubMedID: 20540760 |
| Gene_locus related to this paper: human-PRCP |
| Title : Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase - Araki_2001_J.Biochem_129_279 |
| Author(s) : Araki H , Li Y , Yamamoto Y , Haneda M , Nishi K , Kikkawa R , Ohkubo I |
| Ref : J Biochem , 129 :279 , 2001 |
| Abstract : Araki_2001_J.Biochem_129_279 |
| ESTHER : Araki_2001_J.Biochem_129_279 |
| PubMedSearch : Araki_2001_J.Biochem_129_279 |
| PubMedID: 11173530 |
| Gene_locus related to this paper: ratno-dpp2 |
| Title : Cloning and functional expression of rat kidney dipeptidyl peptidase II - Fukasawa_2001_Biochem.J_353_283 |
| Author(s) : Fukasawa KM , Fukasawa K , Higaki K , Shiina N , Ohno M , Ito S , Otogoto J , Ota N |
| Ref : Biochemical Journal , 353 :283 , 2001 |
| Abstract : Fukasawa_2001_Biochem.J_353_283 |
| ESTHER : Fukasawa_2001_Biochem.J_353_283 |
| PubMedSearch : Fukasawa_2001_Biochem.J_353_283 |
| PubMedID: 11139392 |
| Gene_locus related to this paper: ratno-dpp2 |
| Title : Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus - Bowlus_1999_Cell.Immunol_196_80 |
| Author(s) : Bowlus CL , Ahn J , Chu T , Gruen JR |
| Ref : Cell Immunol , 196 :80 , 1999 |
| Abstract : Bowlus_1999_Cell.Immunol_196_80 |
| ESTHER : Bowlus_1999_Cell.Immunol_196_80 |
| PubMedSearch : Bowlus_1999_Cell.Immunol_196_80 |
| PubMedID: 10527559 |
| Gene_locus related to this paper: human-PRSS16 |
Structures (7)
Genes Proteins in Prolylcarboxypeptidase family (493)
Fragments of genes in Prolylcarboxypeptidase family (52)
Structures in Prolylcarboxypeptidase family (7)Substrates in Prolylcarboxypeptidase family (2)
Inhibitors in Prolylcarboxypeptidase family (8)