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9burk-a0a126zfj3

Variovorax sp. PAMC 28711 S-formylglutathione hydrolase VaSFGH

Comment

VaSFGH has a rigid and small substrate-binding site structure. There is no lid domain. p-nitrophenyl acetate (p-NA, C2), p-nitrophenyl butylate (p-NB, C4), p-nitrophenyl valerate (p-NV, C5), p-nitrophenyl octanoate (p-NO, C8), p-nitrophenyl decanoate (p-ND, C10)

Relationship

Family : A85-EsteraseD-FGH

Block : X

Position in NCBI Life Tree : Variovorax sp. PAMC 28711

Molecular evidence

No mutation

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MTDSIKTLSA HRSFGGVQHF HEHASREIGL PMRFAAYLPP QAEHGKVPAL LYLAGLTCNE ETFMVKAGAQ RLAAELGIAL IAPDTSPRGA HIDGESTSWD FGVGAGFYLD ATAAPWAPNW RMESYLVDEL LPLLAKTLPI DGDRIGVFGH SMGGHGALTL ALRHPGLFKS LSAFAPICAP TQCPWGHKAF TGYLGADTTR WIEHDATVLM QHQPVAPYPA GILIDQGLAD KFLAEQLHPH LLEDACRAIG QPLTLRRHEG YDHGYYFVQS FMADHLAHHA QILNGAIGRP AARQP

References

Title : Structural basis for the substrate specificity of an S-formylglutathione hydrolase derived from Variovorax sp. PAMC 28711 - Hwang_2022_Biochem.Biophys.Res.Commun_629_159
Author(s) : Hwang J , Kim B , Lee MJ , Nam Y , Youn UJ , Lee CS , Oh TJ , Park HH , Do H , Lee JH
Ref : Biochemical & Biophysical Research Communications , 629 :159 , 2022
Abstract : Hwang_2022_Biochem.Biophys.Res.Commun_629_159
ESTHER : Hwang_2022_Biochem.Biophys.Res.Commun_629_159
PubMedSearch : Hwang_2022_Biochem.Biophys.Res.Commun_629_159
PubMedID: 36122453
Gene_locus related to this paper: 9burk-a0a126zfj3