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human-BPHL

Homo sapiens (Human) biphenyl hydrolase-like DJ40E16.6.3, breast epithelial mucin-associated antigen AG BPHL (mcnaa), Valacyclovir hydrolase VACVase

Comment

Valacyclovir hydrolase, biphenyl hydrolase-like, breast epithelial mucin-associated antigen AG BPHL (mcnaa) VACVase. Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. It hydrolyzes the prodrugs of a broad range of antiviral and anticancer nucleoside analogues such as zidovudine, floxuridine, and gemcitabine || OTTHUMG00000014140

Relationship

Family : Valacyclovir-hydrolase

Block : X

Position in NCBI Life Tree : Homo sapiens

Molecular evidence

No mutation

No kinetic

No disease

Database

Sequence

Peptide

MVAVLGGRGV LRLRLLLSAL KPGIHVPRAG PAAAFGTSVT SAKVAVNGVQ LHYQQTGEGD HAVLLLPGML GSGETDFGPQ LKNLNKKLFT VVAWDPRGYG HSRPPDRDFP ADFFERDAKD AVDLMKALKF KKVSLLGWSD GGITALIAAA KYPSYIHKMV IWGANAYVTD EDSMIYEGIR DVSKWSERTR KPLEALYGYD YFARTCEKWV DGIRQFKHLP DGNICRHLLP RVQCPALIVH GEKDPLVPRF HADFIHKHVK GSRLHLMPEG KHNLHLRFAD EFNKLAEDFL Q

References

Title : Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice - Hu_2018_Biochem.Pharmacol_156_147
Author(s) : Hu Y , Epling D , Shi J , Song F , Tsume Y , Zhu HJ , Amidon GL , Smith DE
Ref : Biochemical Pharmacology , 156 :147 , 2018
Abstract : Hu_2018_Biochem.Pharmacol_156_147
ESTHER : Hu_2018_Biochem.Pharmacol_156_147
PubMedSearch : Hu_2018_Biochem.Pharmacol_156_147
PubMedID: 30121252
Gene_locus related to this paper: human-BPHL

Title : Human valacyclovir hydrolase\/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase - Marsillach_2014_PLoS.One_9_e110054
Author(s) : Marsillach J , Suzuki SM , Richter RJ , McDonald MG , Rademacher PM , Maccoss MJ , Hsieh EJ , Rettie AE , Furlong CE
Ref : PLoS ONE , 9 :e110054 , 2014
Abstract : Marsillach_2014_PLoS.One_9_e110054
ESTHER : Marsillach_2014_PLoS.One_9_e110054
PubMedSearch : Marsillach_2014_PLoS.One_9_e110054
PubMedID: 25333274
Gene_locus related to this paper: human-BPHL

Title : Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect - Sun_2010_Mol.Pharm_7_2362
Author(s) : Sun J , Dahan A , Walls ZF , Lai L , Lee KD , Amidon GL
Ref : Mol Pharm , 7 :2362 , 2010
Abstract : Sun_2010_Mol.Pharm_7_2362
ESTHER : Sun_2010_Mol.Pharm_7_2362
PubMedSearch : Sun_2010_Mol.Pharm_7_2362
PubMedID: 21028903
Gene_locus related to this paper: human-BPHL

Title : Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase - Lai_2008_J.Biol.Chem_283_9318
Author(s) : Lai L , Xu Z , Zhou J , Lee KD , Amidon GL
Ref : Journal of Biological Chemistry , 283 :9318 , 2008
Abstract : Lai_2008_J.Biol.Chem_283_9318
ESTHER : Lai_2008_J.Biol.Chem_283_9318
PubMedSearch : Lai_2008_J.Biol.Chem_283_9318
PubMedID: 18256025
Gene_locus related to this paper: human-BPHL

Title : A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein - Kim_2004_Mol.Pharm_1_117
Author(s) : Kim I , Song X , Vig BS , Mittal S , Shin HC , Lorenzi PJ , Amidon GL
Ref : Mol Pharm , 1 :117 , 2004
Abstract : Kim_2004_Mol.Pharm_1_117
ESTHER : Kim_2004_Mol.Pharm_1_117
PubMedSearch : Kim_2004_Mol.Pharm_1_117
PubMedID: 15832508
Gene_locus related to this paper: human-BPHL

Title : Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase - Kim_2003_J.Biol.Chem_278_25348
Author(s) : Kim I , Chu XY , Kim S , Provoda CJ , Lee KD , Amidon GL
Ref : Journal of Biological Chemistry , 278 :25348 , 2003
Abstract : Kim_2003_J.Biol.Chem_278_25348
ESTHER : Kim_2003_J.Biol.Chem_278_25348
PubMedSearch : Kim_2003_J.Biol.Chem_278_25348
PubMedID: 12732646
Gene_locus related to this paper: human-BPHL

Title : The DNA sequence and analysis of human chromosome 6 - Mungall_2003_Nature_425_805
Author(s) : Mungall AJ , Palmer SA , Sims SK , Edwards CA , Ashurst JL , Wilming L , Jones MC , Horton R , Hunt SE , Scott CE , Gilbert JG , Clamp ME , Bethel G , Milne S , Ainscough R , Almeida JP , Ambrose KD , Andrews TD , Ashwell RI , Babbage AK , Bagguley CL , Bailey J , Banerjee R , Barker DJ , Barlow KF , Bates K , Beare DM , Beasley H , Beasley O , Bird CP , Blakey S , Bray-Allen S , Brook J , Brown AJ , Brown JY , Burford DC , Burrill W , Burton J , Carder C , Carter NP , Chapman JC , Clark SY , Clark G , Clee CM , Clegg S , Cobley V , Collier RE , Collins JE , Colman LK , Corby NR , Coville GJ , Culley KM , Dhami P , Davies J , Dunn M , Earthrowl ME , Ellington AE , Evans KA , Faulkner L , Francis MD , Frankish A , Frankland J , French L , Garner P , Garnett J , Ghori MJ , Gilby LM , Gillson CJ , Glithero RJ , Grafham DV , Grant M , Gribble S , Griffiths C , Griffiths M , Hall R , Halls KS , Hammond S , Harley JL , Hart EA , Heath PD , Heathcott R , Holmes SJ , Howden PJ , Howe KL , Howell GR , Huckle E , Humphray SJ , Humphries MD , Hunt AR , Johnson CM , Joy AA , Kay M , Keenan SJ , Kimberley AM , King A , Laird GK , Langford C , Lawlor S , Leongamornlert DA , Leversha M , Lloyd CR , Lloyd DM , Loveland JE , Lovell J , Martin S , Mashreghi-Mohammadi M , Maslen GL , Matthews L , Mccann OT , McLaren SJ , McLay K , McMurray A , Moore MJ , Mullikin JC , Niblett D , Nickerson T , Novik KL , Oliver K , Overton-Larty EK , Parker A , Patel R , Pearce AV , Peck AI , Phillimore B , Phillips S , Plumb RW , Porter KM , Ramsey Y , Ranby SA , Rice CM , Ross MT , Searle SM , Sehra HK , Sheridan E , Skuce CD , Smith S , Smith M , Spraggon L , Squares SL , Steward CA , Sycamore N , Tamlyn-Hall G , Tester J , Theaker AJ , Thomas DW , Thorpe A , Tracey A , Tromans A , Tubby B , Wall M , Wallis JM , West AP , White SS , Whitehead SL , Whittaker H , Wild A , Willey DJ , Wilmer TE , Wood JM , Wray PW , Wyatt JC , Young L , Younger RM , Bentley DR , Coulson A , Durbin R , Hubbard T , Sulston JE , Dunham I , Rogers J , Beck S
Ref : Nature , 425 :805 , 2003
Abstract : Mungall_2003_Nature_425_805
ESTHER : Mungall_2003_Nature_425_805
PubMedSearch : Mungall_2003_Nature_425_805
PubMedID: 14574404
Gene_locus related to this paper: human-ABHD16A , human-BPHL , human-FAM135A , human-PRSS16 , human-SERAC1

Title : Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL) - Puente_1998_Genomics_51_459
Author(s) : Puente XS , Pendas AM , Lopez-Otin C
Ref : Genomics , 51 :459 , 1998
Abstract : Puente_1998_Genomics_51_459
ESTHER : Puente_1998_Genomics_51_459
PubMedSearch : Puente_1998_Genomics_51_459
PubMedID: 9721218
Gene_locus related to this paper: human-BPHL

Title : Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds - Puente_1995_J.Biol.Chem_270_12926
Author(s) : Puente XS , Lopez-Otin C
Ref : Journal of Biological Chemistry , 270 :12926 , 1995
Abstract : Puente_1995_J.Biol.Chem_270_12926
ESTHER : Puente_1995_J.Biol.Chem_270_12926
PubMedSearch : Puente_1995_J.Biol.Chem_270_12926
PubMedID: 7759552
Gene_locus related to this paper: human-BPHL

Title : Cloning and sequencing of a complementary DNA encoding a Mr 70,000 human breast epithelial mucin-associated antigen - Larocca_1990_Cancer.Res_50_5925
Author(s) : Larocca D , Peterson JA , Walkup G , Urrea R , Ceriani RL
Ref : Cancer Research , 50 :5925 , 1990
Abstract : Larocca_1990_Cancer.Res_50_5925
ESTHER : Larocca_1990_Cancer.Res_50_5925
PubMedSearch : Larocca_1990_Cancer.Res_50_5925
PubMedID: 2393862
Gene_locus related to this paper: human-BPHL