human-EPHX2
Homo sapiens (Human) epoxide hydrolase 2, Bifunctional epoxide hydrolase 2 cytosolic (EPHX2) (EC 3.3.2.3) Lipid-phosphate phosphatase (EC 3.1.3.76) Soluble epoxide hydrolase
Comment
The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in the regulation of cardiovascular and renal physiology containing two distinct domains connected via a proline-rich linker. The C-terminal domain contains the EH catalytic activity. The N-terminal domain, has high homology to the haloacid dehalogenase family of phosphatases (not alpha\/beta hydrolase and not included in ESTHER 5MWA is a structure of this part of the protein). Only c-term PfamA Abhydrolase_1 286 540 N-term is HAD haloacid dehalogenase
Relationship
Molecular evidence
No mutation
8S75
8S76
8S77
8QZD
8QVI
8QVK
8QVF
8QVH
8QMZ
8QN0
7EBA
7P4K
7A7G
6YL4
6I5G
6I5E
6HGX
6HGV
6HGW
6FR2
6AUM
5FP0
5ALD
5ALE
5ALF
5ALG
5ALH
5ALI
5ALJ
5ALK
5ALL
5ALM
5ALN
5ALO
5ALP
5ALQ
5ALR
5ALS
5ALT
5ALU
5ALV
5ALW
5ALX
5ALY
5ALZ
5AM0
5AM1
5AM2
5AM3
5AM4
5AM5
5AKX
5AKY
5AKZ
5AKE
5AKG
5AKH
5AKI
5AKJ
5AKK
5AKL
5AK3
5AK4
5AK5
5AK6
5AI4
5AI5
5AI6
5AI8
5AI9
5AIA
5AIB
5AIC
5AI0
5AHX
4X6X
4X6Y
4C4X
4C4Y
4C4Z
3WK9
3WKA
3WKB
3WKC
4Y2X
4Y2V
4Y2U
4Y2T
4Y2S
4Y2R
4Y2Q
4Y2P
4Y2J
4Y2Y
3WKD
3WKE
3WK4
3WK5
3WK6
3WK7
3WK8
4OCZ
4OD0
4HAI
4J03
4JNC
3PDC
3OTQ
3ANS
3ANT
3KOO
3I1Y
3I28
1S8O
1VJ5
1ZD2
1ZD3
1ZD4
1ZD5
No kinetic
No disease
sEH-HDAC6-IN-M9
Epoxykinin
SEH-48-RK4
SEH-45-RK3
SCHEMBL3454366
SCHEMBL3454366-Boc
SCHEMBL3454366-Isobutyryl
ALT-PG2
Glimepiride
FNDP
Adamantyl-urea-Cpd28
Wedelolactone
Dihydroquinazoline-carboxamide-34
Dihydroindole-thiourea-73
TPPU-6-Chlorotacrine-12c
PTUPB
FL217
Benzothiazole-analogue-13f
FAAH_sEH_4.5
CHEMBL2313198
ZINC395065-W9L-4C4Z
ZINC1603176-7WI-4C4Y
CHEMBL3233608-S0J-3WKC
CHEMBL2094355-S0I-3WKB
CHEMBL3233607-S0G-3WKA
CHEMBL3233606-S0F-3WK9
CHEMBL442384-S0E-3WK8
CHEMBL3233605-S0D-3WK7
ZINC527968-S0B-3WK6
CHEMBL3233604-S0C-3WK5
ZINC10109382-S0A-3WK4
CHEMBL3233609-S0K-3WKD
CHEMBL45663-49N-4Y2Q
CHEMBL48137-49O-4Y2R
CHEMBL3402236-49P-4Y2S
CHEMBL3402237-49Q-4Y2T
CHEMBL3402240-4A0-4Y2X
CHEMBL3402239-4A5-4Y2V
SB31184-49R-4Y2U
TK90
UB-EV-52
OWW-6YL4
G3W
TUPS
Regorafenib
Sorafenib
sEH-LTA4H-14
Talinolol
Morpholino-Talinolol
15d-PGJ2
AS2586144
4-Phenylchalcone-oxide
LK864
CHEMBL3402235
CHEMBL3402234
CHEMBL1375713
CHEMBL1818384
t-AUCB
TPPU-methyl
SCHEMBL15272467
TPPU
CHEMBL469792
Fulvestrant
CHEMBL2392714
CHEMBL1689794
CHEMBL1234565
CHEMBL1615212
CHEMBL1615216
24D
33N
34N
nbAUDA
CHEMBL3633668
5ALG-R4N
CHEMBL4465514
SCHEMBL7329991
5ALH-4UA
5ALI-Q3B
5ALU-HD2
5ALZ-XQ9
5AM1-I5T
5ALR-8TM
5ALP-QYD
CHEMBL4451596
1,3-Dicyclohexylurea
AEPU
AUDA
N-1-adamantyl-N'-cyclohexylurea
Hexaethylene-glycol
4-(3-cyclohexyluriedo)-ethanoic-acid
4-(3-cyclohexyluriedo)-butyric-acid
4-(3-cyclohexyluriedo)-hexanoic-acid
4-(3-cyclohexyluriedo)-heptanoic-acid
Diuron
CHEMBL3401634
CHEMBL3114611
Diphenylurea
SCHEMBL19358888
B401
EC5026
GSK2256294A
Ar9281
t-AUCMB
t-MTUCB-NH
t-MTUCB
t-TUCB
SZC
CIU
Database
Sequence
Peptide
HGYVTVKPRV RLHFVELGSG PAVCLCHGFP ESWYSWRYQI PALAQAGYRV LAMDMKGYGE SSAPPEIEEY CMEVLCKEMV TFLDKLGLSQ AVFIGHDWGG MLVWYMALFY PERVRAVASL NTPFIPANPN MSPLESIKAN PVFDYQLYFQ EPGVAEAELE QNLSRTFKSL FRASDESVLS MHKVCEAGGL FVNSPEEPSL SRMVTEEEIQ FYVQQFKKSG FRGPLNWYRN MERNWKWACK SLGRKILIPA LMVTAEKDFV LVPQMSQHME DWIPHLKRGH IEDCGHWTQM DKPTEVNQIL IKWLDSDARN PPVVSKM
References
| Title : Inhibition of soluble epoxide hydrolase as a therapeutic approach for blood-brain barrier dysfunction - Li_2024_Biochimie__ |
| Author(s) : Li S , Song H , Sun Y , Zhang H , Gao Z |
| Ref : Biochimie , : , 2024 |
| Abstract : Li_2024_Biochimie__ |
| ESTHER : Li_2024_Biochimie__ |
| PubMedSearch : Li_2024_Biochimie__ |
| PubMedID: 38531484 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator - Dotsch_2024_J.Med.Chem__ |
| Author(s) : Dotsch L , Davies C , Hennes E , Schonfeld J , Kumar A , Guita C , Ehrler JHM , Hiesinger K , Thavam S , Janning P , Sievers S , Knapp S , Proschak E , Ziegler S , Waldmann H |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : Dotsch_2024_J.Med.Chem__ |
| ESTHER : Dotsch_2024_J.Med.Chem__ |
| PubMedSearch : Dotsch_2024_J.Med.Chem__ |
| PubMedID: 38470246 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Photosensitization enables Pauson-Khand-type reactions with nitrenes - Li_2024_Science_383_498 |
| Author(s) : Li F , Zhu WF , Empel C , Datsenko O , Kumar A , Xu Y , Ehrler JHM , Atodiresei I , Knapp S , Mykhailiuk PK , Proschak E , Koenigs RM |
| Ref : Science , 383 :498 , 2024 |
| Abstract : Li_2024_Science_383_498 |
| ESTHER : Li_2024_Science_383_498 |
| PubMedSearch : Li_2024_Science_383_498 |
| PubMedID: 38301027 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : How Robust Is the Ligand Binding Transition State? - Bose_2023_J.Am.Chem.Soc__ |
| Author(s) : Bose S , Lotz SD , Deb I , Shuck M , Lee KSS , Dickson A |
| Ref : Journal of the American Chemical Society , : , 2023 |
| Abstract : Bose_2023_J.Am.Chem.Soc__ |
| ESTHER : Bose_2023_J.Am.Chem.Soc__ |
| PubMedSearch : Bose_2023_J.Am.Chem.Soc__ |
| PubMedID: 37943667 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress - Peyman_2023_Biomed.Pharmacother_168_115667 |
| Author(s) : Peyman M , Barroso E , Turcu AL , Estrany F, Jr. , Smith D , Jurado-Aguilar J , Rada P , Morisseau C , Hammock BD , Valverde A M , Palomer X , Galdeano C , Vazquez S , Vazquez-Carrera M |
| Ref : Biomed Pharmacother , 168 :115667 , 2023 |
| Abstract : Peyman_2023_Biomed.Pharmacother_168_115667 |
| ESTHER : Peyman_2023_Biomed.Pharmacother_168_115667 |
| PubMedSearch : Peyman_2023_Biomed.Pharmacother_168_115667 |
| PubMedID: 37826940 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction - Wang_2023_ACS.Chem.Biol__ |
| Author(s) : Wang Y , Morisseau C , Takamura A , Wan D , Li D , Sidoli S , Yang J , Wolan DW , Hammock BD , Kitamura S |
| Ref : ACS Chemical Biology , : , 2023 |
| Abstract : Wang_2023_ACS.Chem.Biol__ |
| ESTHER : Wang_2023_ACS.Chem.Biol__ |
| PubMedSearch : Wang_2023_ACS.Chem.Biol__ |
| PubMedID: 36947831 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice - Wu_2023_Neuron__ |
| Author(s) : Wu Y , Dong JH , Dai YF , Zhu MZ , Wang MY , Zhang Y , Pan YD , Yuan XR , Guo ZX , Wang CX , Li YQ , Zhu XH |
| Ref : Neuron , : , 2023 |
| Abstract : Wu_2023_Neuron__ |
| ESTHER : Wu_2023_Neuron__ |
| PubMedSearch : Wu_2023_Neuron__ |
| PubMedID: 37402372 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis - Musella_2023_J.Med.Chem__ |
| Author(s) : Musella S , D'Avino D , Peltner LK , Di Sarno V , Cerqua I , Merciai F , Vestuto V , Ciaglia T , Smaldone G , Di Matteo F , Di Micco S , Napolitano V , Bifulco G , Pepe G , Sommella EM , Basilicata MG , Aquino G , Gomez-Monterrey IM , Campiglia P , Ostacolo C , Roviezzo F , Werz O , Rossi A , Bertamino A |
| Ref : Journal of Medicinal Chemistry , : , 2023 |
| Abstract : Musella_2023_J.Med.Chem__ |
| ESTHER : Musella_2023_J.Med.Chem__ |
| PubMedSearch : Musella_2023_J.Med.Chem__ |
| PubMedID: 37334504 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : CRISPR\/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury - Leuillier_2023_J.Adv.Res_43_163 |
| Author(s) : Leuillier M , Duflot T , Menoret S , Messaoudi H , Djerada Z , Groussard D , Denis RGP , Chevalier L , Karoui A , Panthu B , Thiebaut PA , Schmitz-Afonso I , Nobis S , Campart C , Henry T , Sautreuil C , Luquet SH , Beseme O , Feliu C , Peyret H , Nicol L , Henry JP , Renet S , Mulder P , Wan D , Tesson L , Heslan JM , Duche A , Jacques S , Ziegler F , Brunel V , Rautureau GJP , Monteil C , do Rego JL , do Rego JC , Afonso C , Hammock B , Madec AM , Pinet F , Richard V , Anegon I , Guignabert C , Morisseau C , Bellien J |
| Ref : J Adv Res , 43 :163 , 2023 |
| Abstract : Leuillier_2023_J.Adv.Res_43_163 |
| ESTHER : Leuillier_2023_J.Adv.Res_43_163 |
| PubMedSearch : Leuillier_2023_J.Adv.Res_43_163 |
| PubMedID: 36585106 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model - Sun_2022_Proc.Natl.Acad.Sci.U.S.A_119_ |
| Author(s) : Sun CP , Zhou JJ , Yu ZL , Huo XK , Zhang J , Morisseau C , Hammock BD , Ma XC |
| Ref : Proc Natl Acad Sci U S A , 119 : , 2022 |
| Abstract : Sun_2022_Proc.Natl.Acad.Sci.U.S.A_119_ |
| ESTHER : Sun_2022_Proc.Natl.Acad.Sci.U.S.A_119_ |
| PubMedSearch : Sun_2022_Proc.Natl.Acad.Sci.U.S.A_119_ |
| PubMedID: 35217618 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Computational insights into the known inhibitors of human soluble epoxide hydrolase - Bzowka_2021_Drug.Discov.Today__ |
| Author(s) : Bzowka M , Mitusinska K , Hopko K , Gora A |
| Ref : Drug Discov Today , : , 2021 |
| Abstract : Bzowka_2021_Drug.Discov.Today__ |
| ESTHER : Bzowka_2021_Drug.Discov.Today__ |
| PubMedSearch : Bzowka_2021_Drug.Discov.Today__ |
| PubMedID: 34082135 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists\/Soluble Epoxide Hydrolase Inhibitors - Lillich_2021_J.Med.Chem_64_17259 |
| Author(s) : Lillich FF , Willems S , Ni X , Kilu W , Borkowsky C , Brodsky M , Kramer JS , Brunst S , Hernandez-Olmos V , Heering J , Schierle S , Kestner RI , Mayser FM , Helmstadter M , Gobel T , Weizel L , Namgaladze D , Kaiser A , Steinhilber D , Pfeilschifter W , Kahnt AS , Proschak A , Chaikuad A , Knapp S , Merk D , Proschak E |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : Lillich_2021_J.Med.Chem_64_17259 |
| ESTHER : Lillich_2021_J.Med.Chem_64_17259 |
| PubMedSearch : Lillich_2021_J.Med.Chem_64_17259 |
| PubMedID: 34818007 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase - Hiesinger_2020_J.Med.Chem_63_11498 |
| Author(s) : Hiesinger K , Kramer JS , Beyer S , Eckes T , Brunst S , Flauaus C , Wittmann SK , Weizel L , Kaiser A , Kretschmer SBM , George S , Angioni C , Heering J , Geisslinger G , Schubert-Zsilavecz M , Schmidtko A , Pogoryelov D , Pfeilschifter J , Hofmann B , Steinhilber D , Schwalm S , Proschak E |
| Ref : Journal of Medicinal Chemistry , 63 :11498 , 2020 |
| Abstract : Hiesinger_2020_J.Med.Chem_63_11498 |
| ESTHER : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedSearch : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedID: 33044073 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation - Wang_2020_Proc.Natl.Acad.Sci.U.S.A_117_8431 |
| Author(s) : Wang Y , Yang J , Wang W , Sanidad KZ , Cinelli MA , Wan D , Hwang SH , Kim D , Lee KSS , Xiao H , Hammock BD , Zhang G |
| Ref : Proc Natl Acad Sci U S A , 117 :8431 , 2020 |
| Abstract : Wang_2020_Proc.Natl.Acad.Sci.U.S.A_117_8431 |
| ESTHER : Wang_2020_Proc.Natl.Acad.Sci.U.S.A_117_8431 |
| PubMedSearch : Wang_2020_Proc.Natl.Acad.Sci.U.S.A_117_8431 |
| PubMedID: 32220957 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase - Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| Author(s) : Hiesinger K , Schott A , Kramer JS , Blocher R , Witt F , Wittmann SK , Steinhilber D , Pogoryelov D , Gerstmeier J , Werz O , Proschak E |
| Ref : ACS Med Chem Lett , 11 :298 , 2020 |
| Abstract : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| ESTHER : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedSearch : Hiesinger_2020_ACS.Med.Chem.Lett_11_298 |
| PubMedID: 32184960 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : 15-deoxy-Delta(12,14)-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism - Abis_2019_Commun.Biol_2_188 |
| Author(s) : Abis G , Charles RL , Kopec J , Yue WW , Atkinson RA , Bui TTT , Lynham S , Popova S , Sun YB , Fraternali F , Eaton P , Conte MR |
| Ref : Commun Biol , 2 :188 , 2019 |
| Abstract : Abis_2019_Commun.Biol_2_188 |
| ESTHER : Abis_2019_Commun.Biol_2_188 |
| PubMedSearch : Abis_2019_Commun.Biol_2_188 |
| PubMedID: 31123712 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Computer-Aided Selective Optimization of Side Activities of Talinolol - Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| Author(s) : Hiesinger K , Kramer JS , Achenbach J , Moser D , Weber J , Wittmann SK , Morisseau C , Angioni C , Geisslinger G , Kahnt AS , Kaiser A , Proschak A , Steinhilber D , Pogoryelov D , Wagner K , Hammock BD , Proschak E |
| Ref : ACS Med Chem Lett , 10 :899 , 2019 |
| Abstract : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| ESTHER : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| PubMedSearch : Hiesinger_2019_ACS.Med.Chem.Lett_10_899 |
| PubMedID: 31223445 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Role of sEH R287Q in LDLR expression, LDL binding to LDLR and LDL internalization in BEL-7402 cells - Tang_2018_Gene_667_95 |
| Author(s) : Tang L , Wang G , Jiang L , Chen P , Wang W , Chen J , Wang L |
| Ref : Gene , 667 :95 , 2018 |
| Abstract : Tang_2018_Gene_667_95 |
| ESTHER : Tang_2018_Gene_667_95 |
| PubMedSearch : Tang_2018_Gene_667_95 |
| PubMedID: 29665449 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain - Zimmer_2018_Biochim.Biophys.Acta_1863_669 |
| Author(s) : Zimmer B , Angioni C , Osthues T , Toewe A , Thomas D , Pierre SC , Geisslinger G , Scholich K , Sisignano M |
| Ref : Biochimica & Biophysica Acta , 1863 :669 , 2018 |
| Abstract : Zimmer_2018_Biochim.Biophys.Acta_1863_669 |
| ESTHER : Zimmer_2018_Biochim.Biophys.Acta_1863_669 |
| PubMedSearch : Zimmer_2018_Biochim.Biophys.Acta_1863_669 |
| PubMedID: 29625231 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase - Lukin_2018_Bioorg.Chem_80_655 |
| Author(s) : Lukin A , Kramer J , Hartmann M , Weizel L , Hernandez-Olmos V , Falahati K , Burghardt I , Kalinchenkova N , Bagnyukova D , Zhurilo N , Rautio J , Forsberg M , Ihalainen J , Auriola S , Leppanen J , Konstantinov I , Pogoryelov D , Proschak E , Dar'in D , Krasavin M |
| Ref : Bioorg Chem , 80 :655 , 2018 |
| Abstract : Lukin_2018_Bioorg.Chem_80_655 |
| ESTHER : Lukin_2018_Bioorg.Chem_80_655 |
| PubMedSearch : Lukin_2018_Bioorg.Chem_80_655 |
| PubMedID: 30059891 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase - Kodani_2018_Bioorg.Med.Chem.Lett_28_762 |
| Author(s) : Kodani SD , Bhakta S , Hwang SH , Pakhomova S , Newcomer ME , Morisseau C , Hammock BD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 28 :762 , 2018 |
| Abstract : Kodani_2018_Bioorg.Med.Chem.Lett_28_762 |
| ESTHER : Kodani_2018_Bioorg.Med.Chem.Lett_28_762 |
| PubMedSearch : Kodani_2018_Bioorg.Med.Chem.Lett_28_762 |
| PubMedID: 29366648 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and omega-Hydroxylases - Hanif_2017_PLoS.One_12_e0169584 |
| Author(s) : Hanif A , Edin ML , Zeldin DC , Morisseau C , Falck JR , Nayeem MA |
| Ref : PLoS ONE , 12 :e0169584 , 2017 |
| Abstract : Hanif_2017_PLoS.One_12_e0169584 |
| ESTHER : Hanif_2017_PLoS.One_12_e0169584 |
| PubMedSearch : Hanif_2017_PLoS.One_12_e0169584 |
| PubMedID: 28056085 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa - Shih_2016_Mol.Psychiatry_21_537 |
| Author(s) : Shih PB , Yang J , Morisseau C , German JB , Zeeland AA , Armando AM , Quehenberger O , Bergen AW , Magistretti P , Berrettini W , Halmi KA , Schork N , Hammock BD , Kaye W |
| Ref : Mol Psychiatry , 21 :537 , 2016 |
| Abstract : Shih_2016_Mol.Psychiatry_21_537 |
| ESTHER : Shih_2016_Mol.Psychiatry_21_537 |
| PubMedSearch : Shih_2016_Mol.Psychiatry_21_537 |
| PubMedID: 25824304 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Deletion of soluble epoxide hydrolase enhances coronary reactive hyperemia in isolated mouse heart: role of oxylipins and PPARgamma - Hanif_2016_Am.J.Physiol.Regul.Integr.Comp.Physiol_311_R676 |
| Author(s) : Hanif A , Edin ML , Zeldin DC , Morisseau C , Nayeem MA |
| Ref : American Journal of Physiology Regul Integr Comp Physiol , 311 :R676 , 2016 |
| Abstract : Hanif_2016_Am.J.Physiol.Regul.Integr.Comp.Physiol_311_R676 |
| ESTHER : Hanif_2016_Am.J.Physiol.Regul.Integr.Comp.Physiol_311_R676 |
| PubMedSearch : Hanif_2016_Am.J.Physiol.Regul.Integr.Comp.Physiol_311_R676 |
| PubMedID: 27488890 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration - Xue_2016_ChemMedChem_11_497 |
| Author(s) : Xue Y , Olsson T , Johansson CA , Oster L , Beisel HG , Rohman M , Karis D , Backstrom S |
| Ref : ChemMedChem , 11 :497 , 2016 |
| Abstract : Xue_2016_ChemMedChem_11_497 |
| ESTHER : Xue_2016_ChemMedChem_11_497 |
| PubMedSearch : Xue_2016_ChemMedChem_11_497 |
| PubMedID: 26845235 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase - Manickam_2016_Eur.J.Med.Chem_117_113 |
| Author(s) : Manickam M , Pillaiyar T , Boggu P , Venkateswararao E , Jalani HB , Kim ND , Lee SK , Jeon JS , Kim SK , Jung SH |
| Ref : Eur Journal of Medicinal Chemistry , 117 :113 , 2016 |
| Abstract : Manickam_2016_Eur.J.Med.Chem_117_113 |
| ESTHER : Manickam_2016_Eur.J.Med.Chem_117_113 |
| PubMedSearch : Manickam_2016_Eur.J.Med.Chem_117_113 |
| PubMedID: 27092411 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles - Pilger_2015_Angew.Chem.Int.Ed.Engl_54_6511 |
| Author(s) : Pilger J , Mazur A , Monecke P , Schreuder H , Elshorst B , Bartoschek S , Langer T , Schiffer A , Krimm I , Wegstroth M , Lee D , Hessler G , Wendt KU , Becker S , Griesinger C |
| Ref : Angew Chem Int Ed Engl , 54 :6511 , 2015 |
| Abstract : Pilger_2015_Angew.Chem.Int.Ed.Engl_54_6511 |
| ESTHER : Pilger_2015_Angew.Chem.Int.Ed.Engl_54_6511 |
| PubMedSearch : Pilger_2015_Angew.Chem.Int.Ed.Engl_54_6511 |
| PubMedID: 25877959 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors - Takai_2015_Bioorg.Med.Chem.Lett_25_1705 |
| Author(s) : Takai K , Chiyo N , Nakajima T , Nariai T , Ishikawa C , Nakatani S , Ikeno A , Yamamoto S , Sone T |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :1705 , 2015 |
| Abstract : Takai_2015_Bioorg.Med.Chem.Lett_25_1705 |
| ESTHER : Takai_2015_Bioorg.Med.Chem.Lett_25_1705 |
| PubMedSearch : Takai_2015_Bioorg.Med.Chem.Lett_25_1705 |
| PubMedID: 25800114 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Successful generation of structural information for fragment-based drug discovery - Oster_2015_Drug.Discov.Today_20_1104 |
| Author(s) : Oster L , Tapani S , Xue Y , Kack H |
| Ref : Drug Discov Today , 20 :1104 , 2015 |
| Abstract : Oster_2015_Drug.Discov.Today_20_1104 |
| ESTHER : Oster_2015_Drug.Discov.Today_20_1104 |
| PubMedSearch : Oster_2015_Drug.Discov.Today_20_1104 |
| PubMedID: 25931264 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening - Amano_2015_Bioorg.Med.Chem_23_2310 |
| Author(s) : Amano Y , Tanabe E , Yamaguchi T |
| Ref : Bioorganic & Medicinal Chemistry , : , 2015 |
| Abstract : Amano_2015_Bioorg.Med.Chem_23_2310 |
| ESTHER : Amano_2015_Bioorg.Med.Chem_23_2310 |
| PubMedSearch : Amano_2015_Bioorg.Med.Chem_23_2310 |
| PubMedID: 25862210 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy - Lee_2014_J.Med.Chem_57_7016 |
| Author(s) : Lee KS , Liu JY , Wagner KM , Pakhomova S , Dong H , Morisseau C , Fu SH , Yang J , Wang P , Ulu A , Mate CA , Nguyen LV , Hwang SH , Edin ML , Mara AA , Wulff H , Newcomer ME , Zeldin DC , Hammock BD |
| Ref : Journal of Medicinal Chemistry , 57 :7016 , 2014 |
| Abstract : Lee_2014_J.Med.Chem_57_7016 |
| ESTHER : Lee_2014_J.Med.Chem_57_7016 |
| PubMedSearch : Lee_2014_J.Med.Chem_57_7016 |
| PubMedID: 25079952 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography - Amano_2014_Bioorg.Med.Chem_22_2427 |
| Author(s) : Amano Y , Yamaguchi T , Tanabe E |
| Ref : Bioorganic & Medicinal Chemistry , 22 :2427 , 2014 |
| Abstract : Amano_2014_Bioorg.Med.Chem_22_2427 |
| ESTHER : Amano_2014_Bioorg.Med.Chem_22_2427 |
| PubMedSearch : Amano_2014_Bioorg.Med.Chem_22_2427 |
| PubMedID: 24656800 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans - Ramirez_2014_Prostaglandins.Other.Lipid.Mediat_113-115_38 |
| Author(s) : Ramirez CE , Shuey MM , Milne GL , Gilbert K , Hui N , Yu C , Luther JM , Brown NJ |
| Ref : Prostaglandins Other Lipid Mediat , 113-115 :38 , 2014 |
| Abstract : Ramirez_2014_Prostaglandins.Other.Lipid.Mediat_113-115_38 |
| ESTHER : Ramirez_2014_Prostaglandins.Other.Lipid.Mediat_113-115_38 |
| PubMedSearch : Ramirez_2014_Prostaglandins.Other.Lipid.Mediat_113-115_38 |
| PubMedID: 25173047 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase dimerization is required for hydrolase activity - Nelson_2013_J.Biol.Chem_288_7697 |
| Author(s) : Nelson JW , Subrahmanyan RM , Summers SA , Xiao X , Alkayed NJ |
| Ref : Journal of Biological Chemistry , 288 :7697 , 2013 |
| Abstract : Nelson_2013_J.Biol.Chem_288_7697 |
| ESTHER : Nelson_2013_J.Biol.Chem_288_7697 |
| PubMedSearch : Nelson_2013_J.Biol.Chem_288_7697 |
| PubMedID: 23362272 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides - Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818 |
| Author(s) : Morisseau C , Pakhomova S , Hwang SH , Newcomer ME , Hammock BD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :3818 , 2013 |
| Abstract : Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818 |
| ESTHER : Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818 |
| PubMedSearch : Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818 |
| PubMedID: 23684894 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase - Thalji_2013_Bioorg.Med.Chem.Lett_23_3584 |
| Author(s) : Thalji RK , McAtee JJ , Belyanskaya S , Brandt M , Brown GD , Costell MH , Ding Y , Dodson JW , Eisennagel SH , Fries RE , Gross JW , Harpel MR , Holt DA , Israel DI , Jolivette LJ , Krosky D , Li H , Lu Q , Mandichak T , Roethke T , Schnackenberg CG , Schwartz B , Shewchuk LM , Xie W , Behm DJ , Douglas SA , Shaw AL , Marino JP, Jr. |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :3584 , 2013 |
| Abstract : Thalji_2013_Bioorg.Med.Chem.Lett_23_3584 |
| ESTHER : Thalji_2013_Bioorg.Med.Chem.Lett_23_3584 |
| PubMedSearch : Thalji_2013_Bioorg.Med.Chem.Lett_23_3584 |
| PubMedID: 23664879 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors - Pecic_2013_Bioorg.Med.Chem.Lett_23_417 |
| Author(s) : Pecic S , Pakhomova S , Newcomer ME , Morisseau C , Hammock BD , Zhu Z , Rinderspacher A , Deng SX |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :417 , 2013 |
| Abstract : Pecic_2013_Bioorg.Med.Chem.Lett_23_417 |
| ESTHER : Pecic_2013_Bioorg.Med.Chem.Lett_23_417 |
| PubMedSearch : Pecic_2013_Bioorg.Med.Chem.Lett_23_417 |
| PubMedID: 23237835 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : A practical use of ligand efficiency indices out of the fragment-based approach: ligand efficiency-guided lead identification of soluble epoxide hydrolase inhibitors - Tanaka_2011_J.Med.Chem_54_851 |
| Author(s) : Tanaka D , Tsuda Y , Shiyama T , Nishimura T , Chiyo N , Tominaga Y , Sawada N , Mimoto T , Kusunose N |
| Ref : Journal of Medicinal Chemistry , 54 :851 , 2011 |
| Abstract : Tanaka_2011_J.Med.Chem_54_851 |
| ESTHER : Tanaka_2011_J.Med.Chem_54_851 |
| PubMedSearch : Tanaka_2011_J.Med.Chem_54_851 |
| PubMedID: 21192659 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Discovery of potent inhibitors of soluble epoxide hydrolase by combinatorial library design and structure-based virtual screening - Xing_2011_J.Med.Chem_54_1211 |
| Author(s) : Xing L , McDonald JJ , Kolodziej SA , Kurumbail RG , Williams JM , Warren CJ , O'Neal JM , Skepner JE , Roberds SL |
| Ref : Journal of Medicinal Chemistry , 54 :1211 , 2011 |
| Abstract : Xing_2011_J.Med.Chem_54_1211 |
| ESTHER : Xing_2011_J.Med.Chem_54_1211 |
| PubMedSearch : Xing_2011_J.Med.Chem_54_1211 |
| PubMedID: 21302953 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain - Lo_2010_Bioorg.Med.Chem.Lett_20_6379 |
| Author(s) : Lo HY , Man CC , Fleck RW , Farrow NA , Ingraham RH , Kukulka A , Proudfoot JR , Betageri R , Kirrane T , Patel U , Sharma R , Hoermann MA , Kabcenell A , Lombaert SD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6379 , 2010 |
| Abstract : Lo_2010_Bioorg.Med.Chem.Lett_20_6379 |
| ESTHER : Lo_2010_Bioorg.Med.Chem.Lett_20_6379 |
| PubMedSearch : Lo_2010_Bioorg.Med.Chem.Lett_20_6379 |
| PubMedID: 20934334 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase - Eldrup_2009_J.Med.Chem_52_5880 |
| Author(s) : Eldrup AB , Soleymanzadeh F , Taylor SJ , Muegge I , Farrow NA , Joseph D , McKellop K , Man CC , Kukulka A , De Lombaert S |
| Ref : Journal of Medicinal Chemistry , 52 :5880 , 2009 |
| Abstract : Eldrup_2009_J.Med.Chem_52_5880 |
| ESTHER : Eldrup_2009_J.Med.Chem_52_5880 |
| PubMedSearch : Eldrup_2009_J.Med.Chem_52_5880 |
| PubMedID: 19746975 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase: a new target for cardioprotection - Gross_2009_Curr.Opin.Investig.Drugs_10_253 |
| Author(s) : Gross GJ , Nithipatikom K |
| Ref : Curr Opin Investig Drugs , 10 :253 , 2009 |
| Abstract : Gross_2009_Curr.Opin.Investig.Drugs_10_253 |
| ESTHER : Gross_2009_Curr.Opin.Investig.Drugs_10_253 |
| PubMedSearch : Gross_2009_Curr.Opin.Investig.Drugs_10_253 |
| PubMedID: 19333883 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo - Motoki_2008_Am.J.Physiol.Heart.Circ.Physiol_295_H2128 |
| Author(s) : Motoki A , Merkel MJ , Packwood WH , Cao Z , Liu L , Iliff J , Alkayed NJ , Van Winkle DM |
| Ref : American Journal of Physiology Heart Circ Physiol , 295 :H2128 , 2008 |
| Abstract : Motoki_2008_Am.J.Physiol.Heart.Circ.Physiol_295_H2128 |
| ESTHER : Motoki_2008_Am.J.Physiol.Heart.Circ.Physiol_295_H2128 |
| PubMedSearch : Motoki_2008_Am.J.Physiol.Heart.Circ.Physiol_295_H2128 |
| PubMedID: 18835921 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury - Koerner_2007_J.Neurosci_27_4642 |
| Author(s) : Koerner IP , Jacks R , DeBarber AE , Koop D , Mao P , Grant DF , Alkayed NJ |
| Ref : Journal of Neuroscience , 27 :4642 , 2007 |
| Abstract : Koerner_2007_J.Neurosci_27_4642 |
| ESTHER : Koerner_2007_J.Neurosci_27_4642 |
| PubMedSearch : Koerner_2007_J.Neurosci_27_4642 |
| PubMedID: 17460077 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase - Kim_2007_Bioorg.Med.Chem_15_312 |
| Author(s) : Kim IH , Nishi K , Tsai HJ , Bradford T , Koda Y , Watanabe T , Morisseau C , Blanchfield J , Toth I , Hammock BD |
| Ref : Bioorganic & Medicinal Chemistry , 15 :312 , 2007 |
| Abstract : Kim_2007_Bioorg.Med.Chem_15_312 |
| ESTHER : Kim_2007_Bioorg.Med.Chem_15_312 |
| PubMedSearch : Kim_2007_Bioorg.Med.Chem_15_312 |
| PubMedID: 17046265 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase: a novel therapeutic target in stroke - Zhang_2007_J.Cereb.Blood.Flow.Metab_27_1931 |
| Author(s) : Zhang W , Koerner IP , Noppens R , Grafe M , Tsai HJ , Morisseau C , Luria A , Hammock BD , Falck JR , Alkayed NJ |
| Ref : Journal of Cerebral Blood Flow & Metabolism , 27 :1931 , 2007 |
| Abstract : Zhang_2007_J.Cereb.Blood.Flow.Metab_27_1931 |
| ESTHER : Zhang_2007_J.Cereb.Blood.Flow.Metab_27_1931 |
| PubMedSearch : Zhang_2007_J.Cereb.Blood.Flow.Metab_27_1931 |
| PubMedID: 17440491 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels - Olearczyk_2006_J.Pharmacol.Exp.Ther_318_1307 |
| Author(s) : Olearczyk JJ , Field MB , Kim IH , Morisseau C , Hammock BD , Imig JD |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 318 :1307 , 2006 |
| Abstract : Olearczyk_2006_J.Pharmacol.Exp.Ther_318_1307 |
| ESTHER : Olearczyk_2006_J.Pharmacol.Exp.Ther_318_1307 |
| PubMedSearch : Olearczyk_2006_J.Pharmacol.Exp.Ther_318_1307 |
| PubMedID: 16772540 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids - Gomez_2006_Protein.Sci_15_58 |
| Author(s) : Gomez GA , Morisseau C , Hammock BD , Christianson DW |
| Ref : Protein Science , 15 :58 , 2006 |
| Abstract : Gomez_2006_Protein.Sci_15_58 |
| ESTHER : Gomez_2006_Protein.Sci_15_58 |
| PubMedSearch : Gomez_2006_Protein.Sci_15_58 |
| PubMedID: 16322563 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors - Schmelzer_2006_Proc.Natl.Acad.Sci.U.S.A_103_13646 |
| Author(s) : Schmelzer KR , Inceoglu B , Kubala L , Kim IH , Jinks SL , Eiserich JP , Hammock BD |
| Ref : Proc Natl Acad Sci U S A , 103 :13646 , 2006 |
| Abstract : Schmelzer_2006_Proc.Natl.Acad.Sci.U.S.A_103_13646 |
| ESTHER : Schmelzer_2006_Proc.Natl.Acad.Sci.U.S.A_103_13646 |
| PubMedSearch : Schmelzer_2006_Proc.Natl.Acad.Sci.U.S.A_103_13646 |
| PubMedID: 16950874 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase is a therapeutic target for acute inflammation - Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772 |
| Author(s) : Schmelzer KR , Kubala L , Newman JW , Kim IH , Eiserich JP , Hammock BD |
| Ref : Proc Natl Acad Sci U S A , 102 :9772 , 2005 |
| Abstract : Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772 |
| ESTHER : Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772 |
| PubMedSearch : Schmelzer_2005_Proc.Natl.Acad.Sci.U.S.A_102_9772 |
| PubMedID: 15994227 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred - Sato_2004_J.Hum.Genet_49_29 |
| Author(s) : Sato K , Emi M , Ezura Y , Fujita Y , Takada D , Ishigami T , Umemura S , Xin Y , Wu LL , Larrinaga-Shum S , Stephenson SH , Hunt SC , Hopkins PN |
| Ref : J Hum Genet , 49 :29 , 2004 |
| Abstract : Sato_2004_J.Hum.Genet_49_29 |
| ESTHER : Sato_2004_J.Hum.Genet_49_29 |
| PubMedSearch : Sato_2004_J.Hum.Genet_49_29 |
| PubMedID: 14673705 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study - Fornage_2004_Circulation_109_335 |
| Author(s) : Fornage M , Boerwinkle E , Doris PA , Jacobs D , Liu K , Wong ND |
| Ref : Circulation , 109 :335 , 2004 |
| Abstract : Fornage_2004_Circulation_109_335 |
| ESTHER : Fornage_2004_Circulation_109_335 |
| PubMedSearch : Fornage_2004_Circulation_109_335 |
| PubMedID: 14732757 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis - Gomez_2004_Biochemistry_43_4716 |
| Author(s) : Gomez GA , Morisseau C , Hammock BD , Christianson DW |
| Ref : Biochemistry , 43 :4716 , 2004 |
| Abstract : Gomez_2004_Biochemistry_43_4716 |
| ESTHER : Gomez_2004_Biochemistry_43_4716 |
| PubMedSearch : Gomez_2004_Biochemistry_43_4716 |
| PubMedID: 15096040 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity - Newman_2003_Proc.Natl.Acad.Sci.U.S.A_100_1558 |
| Author(s) : Newman JW , Morisseau C , Harris TR , Hammock BD |
| Ref : Proc Natl Acad Sci U S A , 100 :1558 , 2003 |
| Abstract : Newman_2003_Proc.Natl.Acad.Sci.U.S.A_100_1558 |
| ESTHER : Newman_2003_Proc.Natl.Acad.Sci.U.S.A_100_1558 |
| PubMedSearch : Newman_2003_Proc.Natl.Acad.Sci.U.S.A_100_1558 |
| PubMedID: 12574510 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Polymorphisms in human soluble epoxide hydrolase - Przybyla-Zawislak_2003_Mol.Pharmacol_64_482 |
| Author(s) : Przybyla-Zawislak BD , Srivastava PK , Vazquez-Matias J , Mohrenweiser HW , Maxwell JE , Hammock BD , Bradbury JA , Enayetallah AE , Zeldin DC , Grant DF |
| Ref : Molecular Pharmacology , 64 :482 , 2003 |
| Abstract : Przybyla-Zawislak_2003_Mol.Pharmacol_64_482 |
| ESTHER : Przybyla-Zawislak_2003_Mol.Pharmacol_64_482 |
| PubMedSearch : Przybyla-Zawislak_2003_Mol.Pharmacol_64_482 |
| PubMedID: 12869654 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Seventy genetic variations in human microsomal and soluble epoxide hydrolase genes (EPHX1 and EPHX2) in the Japanese population - Saito_2001_J.Hum.Genet_46_325 |
| Author(s) : Saito S , Iida A , Sekine A , Eguchi C , Miura Y , Nakamura Y |
| Ref : J Hum Genet , 46 :325 , 2001 |
| Abstract : Saito_2001_J.Hum.Genet_46_325 |
| ESTHER : Saito_2001_J.Hum.Genet_46_325 |
| PubMedSearch : Saito_2001_J.Hum.Genet_46_325 |
| PubMedID: 11393535 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Identification of 6 new polymorphisms, g.11177G>A, g.14622C>T (R49C), g.17540T>C, g.17639T>C, g.30929T>C, g.31074G>A (R454Q), in the human microsomal epoxide hydrolase gene (EPHX1) in a French population - |
| Author(s) : Belmahdi F , Chevalier D , Lo-Guidice JM , Allorge D , Cauffiez C , Lafitte JJ , Broly F |
| Ref : Hum Mutat , 16 :450 , 2000 |
| PubMedID: 11058921 |
| Gene_locus related to this paper: human-EPHX1 , human-EPHX2 |
| Title : Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms - Sandberg_2000_J.Biol.Chem_275_28873 |
| Author(s) : Sandberg M , Hassett C , Adman ET , Meijer J , Omiecinski CJ |
| Ref : Journal of Biological Chemistry , 275 :28873 , 2000 |
| Abstract : Sandberg_2000_J.Biol.Chem_275_28873 |
| ESTHER : Sandberg_2000_J.Biol.Chem_275_28873 |
| PubMedSearch : Sandberg_2000_J.Biol.Chem_275_28873 |
| PubMedID: 10862610 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Structural characterization of the human soluble epoxide hydrolase gene (EPHX2) - Sandberg_1996_Biochem.Biophys.Res.Commun_221_333 |
| Author(s) : Sandberg M , Meijer J |
| Ref : Biochemical & Biophysical Research Communications , 221 :333 , 1996 |
| Abstract : Sandberg_1996_Biochem.Biophys.Res.Commun_221_333 |
| ESTHER : Sandberg_1996_Biochem.Biophys.Res.Commun_221_333 |
| PubMedSearch : Sandberg_1996_Biochem.Biophys.Res.Commun_221_333 |
| PubMedID: 8619856 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Localization of the human soluble epoxide hydrolase gene (EPHX2) to chromosomal region 8p21-p12 - Larsson_1995_Hum.Genet_95_356 |
| Author(s) : Larsson C , White I , Johansson C , Stark A , Meijer J |
| Ref : Hum Genet , 95 :356 , 1995 |
| Abstract : Larsson_1995_Hum.Genet_95_356 |
| ESTHER : Larsson_1995_Hum.Genet_95_356 |
| PubMedSearch : Larsson_1995_Hum.Genet_95_356 |
| PubMedID: 7868134 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : cDNA cloning and expression of a soluble epoxide hydrolase from human liver - Beetham_1993_Arch.Biochem.Biophys_305_197 |
| Author(s) : Beetham JK , Tian T , Hammock BD |
| Ref : Archives of Biochemistry & Biophysics , 305 :197 , 1993 |
| Abstract : Beetham_1993_Arch.Biochem.Biophys_305_197 |
| ESTHER : Beetham_1993_Arch.Biochem.Biophys_305_197 |
| PubMedSearch : Beetham_1993_Arch.Biochem.Biophys_305_197 |
| PubMedID: 8342951 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Purification of human liver cytosolic epoxide hydrolase and comparison to the microsomal enzyme - Wang_1982_Biochemistry_21_5769 |
| Author(s) : Wang P , Meijer J , Guengerich FP |
| Ref : Biochemistry , 21 :5769 , 1982 |
| Abstract : Wang_1982_Biochemistry_21_5769 |
| ESTHER : Wang_1982_Biochemistry_21_5769 |
| PubMedSearch : Wang_1982_Biochemistry_21_5769 |
| PubMedID: 6185139 |
| Gene_locus related to this paper: human-EPHX1 , human-EPHX2 |