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human-ESD

Homo sapiens (Human) esterase D (EC 3.1.1.1) formylglutathione hydrolase

Comment

Q9BVJ2 (Homo sapiens (Human) similar to esterase 10) one aa different from P10768 || Human esterase D (hEstD),1 also called S-formylglutathione hydrolase (SFGH, EC 3.1.2.12), is a ubiquitous intracellular carboxylesterase (CE). hEstD can be found in blood cells and most human tissues and is one of the major CE activities detectable in cytosolic fractions of human liver. SFGH hydrolyzes a range of uncharged ester substrates in vitro, including p-nitrophenyl acetate (pNPA) and 4-methylumbelliferyl acetate. EstD is a thioesterase involved in the removal of genotoxic formaldehyde via a glutathione-dependent reaction. The enzyme may also play a role in xenobiotic metabolism. EstD can be induced in human cells by exposure to methylmethane sulfonate or phenobarbital

Relationship

Family : A85-EsteraseD-FGH

Block : X

Position in NCBI Life Tree : Homo sapiens

Molecular evidence

No mutation

No kinetic

No disease

No inhibitor

Database

Sequence

Peptide

MALKQISSNK CFGGLQKVFE HDSVELNCKM KFAVYLPPKA ETGKCPALYW LSGLTCTEQN FISKSGYHQS ASEHGLVVIA PDTSPRGCNI KGEDESWDFG TGAGFYVDAT EDPWKTNYRM YSYVTEELPQ LINANFPVDP QRMSIFGHSM GGHGALICAL KNPGKYKSVS AFAPICNPVL CPWGKKAFSG YLGTDQSKWK AYDATHLVKS YPGSQLDILI DQGKDDQFLL DGQLLPDNFI AACTEKKIPV VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA

References

Title : Esterase D interacts with metallothionein 2A and inhibits the migration of A549 lung cancer cells in vitro - Yao_2023_J.Cell.Biochem__
Author(s) : Yao W , Chen X , Cui X , Zhou B , Zhao B , Lin Z , Miao J
Ref : Journal of Cellular Biochemistry , : , 2023
Abstract : Yao_2023_J.Cell.Biochem__
ESTHER : Yao_2023_J.Cell.Biochem__
PubMedSearch : Yao_2023_J.Cell.Biochem__
PubMedID: 36649442
Gene_locus related to this paper: human-ESD

Title : Crystal structure of human esterase D: a potential genetic marker of retinoblastoma - Wu_2009_FASEB.J_23_1441
Author(s) : Wu D , Li Y , Song G , Zhang D , Shaw N , Liu ZJ
Ref : FASEB Journal , 23 :1441 , 2009
Abstract : Wu_2009_FASEB.J_23_1441
ESTHER : Wu_2009_FASEB.J_23_1441
PubMedSearch : Wu_2009_FASEB.J_23_1441
PubMedID: 19126594
Gene_locus related to this paper: human-ESD

Title : The DNA sequence and analysis of human chromosome 13 - Dunham_2004_Nature_428_522
Author(s) : Dunham A , Matthews LH , Burton J , Ashurst JL , Howe KL , Ashcroft KJ , Beare DM , Burford DC , Hunt SE , Griffiths-Jones S , Jones MC , Keenan SJ , Oliver K , Scott CE , Ainscough R , Almeida JP , Ambrose KD , Andrews DT , Ashwell RI , Babbage AK , Bagguley CL , Bailey J , Bannerjee R , Barlow KF , Bates K , Beasley H , Bird CP , Bray-Allen S , Brown AJ , Brown JY , Burrill W , Carder C , Carter NP , Chapman JC , Clamp ME , Clark SY , Clarke G , Clee CM , Clegg SC , Cobley V , Collins JE , Corby N , Coville GJ , Deloukas P , Dhami P , Dunham I , Dunn M , Earthrowl ME , Ellington AG , Faulkner L , Frankish AG , Frankland J , French L , Garner P , Garnett J , Gilbert JG , Gilson CJ , Ghori J , Grafham DV , Gribble SM , Griffiths C , Hall RE , Hammond S , Harley JL , Hart EA , Heath PD , Howden PJ , Huckle EJ , Hunt PJ , Hunt AR , Johnson C , Johnson D , Kay M , Kimberley AM , King A , Laird GK , Langford CJ , Lawlor S , Leongamornlert DA , Lloyd DM , Lloyd C , Loveland JE , Lovell J , Martin S , Mashreghi-Mohammadi M , McLaren SJ , McMurray A , Milne S , Moore MJ , Nickerson T , Palmer SA , Pearce AV , Peck AI , Pelan S , Phillimore B , Porter KM , Rice CM , Searle S , Sehra HK , Shownkeen R , Skuce CD , Smith M , Steward CA , Sycamore N , Tester J , Thomas DW , Tracey A , Tromans A , Tubby B , Wall M , Wallis JM , West AP , Whitehead SL , Willey DL , Wilming L , Wray PW , Wright MW , Young L , Coulson A , Durbin R , Hubbard T , Sulston JE , Beck S , Bentley DR , Rogers J , Ross MT
Ref : Nature , 428 :522 , 2004
Abstract : Dunham_2004_Nature_428_522
ESTHER : Dunham_2004_Nature_428_522
PubMedSearch : Dunham_2004_Nature_428_522
PubMedID: 15057823
Gene_locus related to this paper: human-ESD , human-TEX30

Title : Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population - Saito_2003_J.Hum.Genet_48_249
Author(s) : Saito S , Iida A , Sekine A , Kawauchi S , Higuchi S , Ogawa C , Nakamura Y
Ref : J Hum Genet , 48 :249 , 2003
Abstract : Saito_2003_J.Hum.Genet_48_249
ESTHER : Saito_2003_J.Hum.Genet_48_249
PubMedSearch : Saito_2003_J.Hum.Genet_48_249
PubMedID: 12721789
Gene_locus related to this paper: human-CES2 , human-ESD

Title : Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning - Hu_2000_Proc.Natl.Acad.Sci.U.S.A_97_9543
Author(s) : Hu RM , Han ZG , Song HD , Peng YD , Huang QH , Ren SX , Gu YJ , Huang CH , Li YB , Jiang CL , Fu G , Zhang QH , Gu BW , Dai M , Mao YF , Gao GF , Rong R , Ye M , Zhou J , Xu SH , Gu J , Shi JX , Jin WR , Zhang CK , Wu TM , Huang GY , Chen Z , Chen MD , Chen JL
Ref : Proc Natl Acad Sci U S A , 97 :9543 , 2000
Abstract : Hu_2000_Proc.Natl.Acad.Sci.U.S.A_97_9543
ESTHER : Hu_2000_Proc.Natl.Acad.Sci.U.S.A_97_9543
PubMedSearch : Hu_2000_Proc.Natl.Acad.Sci.U.S.A_97_9543
PubMedID: 10931946
Gene_locus related to this paper: human-ESD

Title : Molecular analysis of esterase D polymorphism - Tsuchida_1994_Hum.Genet_93_255
Author(s) : Tsuchida S , Fukui E , Ikemoto S
Ref : Hum Genet , 93 :255 , 1994
Abstract : Tsuchida_1994_Hum.Genet_93_255
ESTHER : Tsuchida_1994_Hum.Genet_93_255
PubMedSearch : Tsuchida_1994_Hum.Genet_93_255
PubMedID: 7907313
Gene_locus related to this paper: human-ESD

Title : Human esterase D gene: complete cDNA sequence, genomic structure, and application in the genetic diagnosis of human retinoblastoma - Young_1988_Hum.Genet_79_137
Author(s) : Young LJ , Lee EY , To HA , Bookstein R , Shew JY , Donoso LA , Sery T , Giblin M , Shields JA , Lee WH
Ref : Hum Genet , 79 :137 , 1988
Abstract : Young_1988_Hum.Genet_79_137
ESTHER : Young_1988_Hum.Genet_79_137
PubMedSearch : Young_1988_Hum.Genet_79_137
PubMedID: 3164702
Gene_locus related to this paper: human-ESD

Title : Molecular cloning of the human esterase D gene, a genetic marker of retinoblastoma - Lee_1986_Proc.Natl.Acad.Sci.U.S.A_83_6337
Author(s) : Lee EY , Lee WH
Ref : Proc Natl Acad Sci U S A , 83 :6337 , 1986
Abstract : Lee_1986_Proc.Natl.Acad.Sci.U.S.A_83_6337
ESTHER : Lee_1986_Proc.Natl.Acad.Sci.U.S.A_83_6337
PubMedSearch : Lee_1986_Proc.Natl.Acad.Sci.U.S.A_83_6337
PubMedID: 3462698
Gene_locus related to this paper: human-ESD

Title : Cloning of the esterase D gene: a polymorphic gene probe closely linked to the retinoblastoma locus on chromosome 13 - Squire_1986_Proc.Natl.Acad.Sci.U.S.A_83_6573
Author(s) : Squire J , Dryja TP , Dunn J , Goddard A , Hofmann T , Musarella M , Willard HF , Becker AJ , Gallie BL , Phillips RA
Ref : Proc Natl Acad Sci U S A , 83 :6573 , 1986
Abstract : Squire_1986_Proc.Natl.Acad.Sci.U.S.A_83_6573
ESTHER : Squire_1986_Proc.Natl.Acad.Sci.U.S.A_83_6573
PubMedSearch : Squire_1986_Proc.Natl.Acad.Sci.U.S.A_83_6573
PubMedID: 3462714
Gene_locus related to this paper: human-ESD