Homo sapiens (Human) KAT8 regulatory NSL complex subunit 3, Testis development protein PRTD, KIAA1310, PRTD, SI1, FLJ10081, NSL3, Rcd1
Old K1310_HUMAN human-Q86T19. || only central part Pfam A Abhydrolase_5 289 436. KANSL3 is a subunit of a nonspecific lethal (NSL) histone acetyltransferase (HAT) complex that acetylates core histone H4. NSL3 and the O-linked N-acetylglucosamine (O-GlcNAc) transferase OGT1 are subunits of an NSL HAT complex that acetylates histone H4 residues lys5 (K5), K8, and K16. Knockdown of OGT1 or NSL3 reduced global H4K16 acetylation in a dose-dependent manner. Immunoprecipitation analysis in HEK293 and HeLa cells revealed that endogenous OGT1 and NSL3 interacted, and mutation analysis revealed that the N-terminal TPR repeat domain of OGT1 interacted with the abhydrolase domain of NSL3. In vitro, OGT1 catalyzed O-GlcNAc modification of NSL3 in the presence of donor UDP-GlcNAc. The O-GlcNAc modification stabilized NSL3, and stabilized NSL3 was required for H4K16 acetylation by the HAT NSL complex
NKPSKLPGSP LILIASSGPS SSVFPTSRRH RFWQSQLSCL GKVIPVATHL LNNGSGVGVL QCLEHMIGAV RSKVLEIHSH FPHKPIILIG WNTGALVACH VSVMEYVTAV VCLGFPLLTV DGPRGDVDDP LLDMKTPVLF VIGQNSLQCH PEAMEDFREK IRAENSLVVV GGADDNLRIS KAKKKSEGLT QSMVDRCIQD EIVDFLTGVL TRA
Title : O-Linked N-acetylglucosamine transferase 1 regulates global histone H4 acetylation via stabilization of the nonspecific lethal protein NSL3 - Wu_2017_J.Biol.Chem_292_10014 |
Author(s) : Wu D , Zhao L , Feng Z , Yu C , Ding J , Wang L , Wang F , Liu D , Zhu H , Xing F , Conaway JW , Conaway RC , Cai Y , Jin J |
Ref : Journal of Biological Chemistry , 292 :10014 , 2017 |
Abstract : Wu_2017_J.Biol.Chem_292_10014 |
ESTHER : Wu_2017_J.Biol.Chem_292_10014 |
PubMedSearch : Wu_2017_J.Biol.Chem_292_10014 |
PubMedID: 28450392 |
Gene_locus related to this paper: human-KANSL3 |
Title : An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis - Meunier_2015_Nat.Commun_6_7889 |
Author(s) : Meunier S , Shvedunova M , Van Nguyen N , Avila L , Vernos I , Akhtar A |
Ref : Nat Commun , 6 :7889 , 2015 |
Abstract : Meunier_2015_Nat.Commun_6_7889 |
ESTHER : Meunier_2015_Nat.Commun_6_7889 |
PubMedSearch : Meunier_2015_Nat.Commun_6_7889 |
PubMedID: 26243146 |
Gene_locus related to this paper: human-KANSL3 |
Title : Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex - Cai_2010_J.Biol.Chem_285_4268 |
Author(s) : Cai Y , Jin J , Swanson SK , Cole MD , Choi SH , Florens L , Washburn MP , Conaway JW , Conaway RC |
Ref : Journal of Biological Chemistry , 285 :4268 , 2010 |
Abstract : Cai_2010_J.Biol.Chem_285_4268 |
ESTHER : Cai_2010_J.Biol.Chem_285_4268 |
PubMedSearch : Cai_2010_J.Biol.Chem_285_4268 |
PubMedID: 20018852 |
Gene_locus related to this paper: human-KANSL3 |
Title : Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach - Gauci_2009_Anal.Chem_81_4493 |
Author(s) : Gauci S , Helbig AO , Slijper M , Krijgsveld J , Heck AJ , Mohammed S |
Ref : Analytical Chemistry , 81 :4493 , 2009 |
Abstract : Gauci_2009_Anal.Chem_81_4493 |
ESTHER : Gauci_2009_Anal.Chem_81_4493 |
PubMedSearch : Gauci_2009_Anal.Chem_81_4493 |
PubMedID: 19413330 |
Gene_locus related to this paper: human-KANSL3 |
Title : A quantitative atlas of mitotic phosphorylation - Dephoure_2008_Proc.Natl.Acad.Sci.U.S.A_105_10762 |
Author(s) : Dephoure N , Zhou C , Villen J , Beausoleil SA , Bakalarski CE , Elledge SJ , Gygi SP |
Ref : Proc Natl Acad Sci U S A , 105 :10762 , 2008 |
Abstract : Dephoure_2008_Proc.Natl.Acad.Sci.U.S.A_105_10762 |
ESTHER : Dephoure_2008_Proc.Natl.Acad.Sci.U.S.A_105_10762 |
PubMedSearch : Dephoure_2008_Proc.Natl.Acad.Sci.U.S.A_105_10762 |
PubMedID: 18669648 |
Gene_locus related to this paper: human-KANSL3 |
Title : Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila - Mendjan_2006_Mol.Cell_21_811 |
Author(s) : Mendjan S , Taipale M , Kind J , Holz H , Gebhardt P , Schelder M , Vermeulen M , Buscaino A , Duncan K , Mueller J , Wilm M , Stunnenberg HG , Saumweber H , Akhtar A |
Ref : Mol Cell , 21 :811 , 2006 |
Abstract : Mendjan_2006_Mol.Cell_21_811 |
ESTHER : Mendjan_2006_Mol.Cell_21_811 |
PubMedSearch : Mendjan_2006_Mol.Cell_21_811 |
PubMedID: 16543150 |
Gene_locus related to this paper: human-KANSL3 |
Title : Large-scale characterization of HeLa cell nuclear phosphoproteins - Beausoleil_2004_Proc.Natl.Acad.Sci.U.S.A_101_12130 |
Author(s) : Beausoleil SA , Jedrychowski M , Schwartz D , Elias JE , Villen J , Li J , Cohn MA , Cantley LC , Gygi SP |
Ref : Proc Natl Acad Sci U S A , 101 :12130 , 2004 |
Abstract : Beausoleil_2004_Proc.Natl.Acad.Sci.U.S.A_101_12130 |
ESTHER : Beausoleil_2004_Proc.Natl.Acad.Sci.U.S.A_101_12130 |
PubMedSearch : Beausoleil_2004_Proc.Natl.Acad.Sci.U.S.A_101_12130 |
PubMedID: 15302935 |
Gene_locus related to this paper: human-KANSL3 |
Title : Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs - Wiemann_2001_Genome.Res_11_422 |
Author(s) : Wiemann S , Weil B , Wellenreuther R , Gassenhuber J , Glassl S , Ansorge W , Boecher M , Bloecker H , Bauersachs S , Blum H , Lauber J , Duesterhoeft A , Beyer A , Koehrer K , Strack N , Mewes H-W , Ottenwaelder B , Obermaier B , Tampe J , Heubner D , Wambutt R , Korn B , Klein M , Poustka A , Bocher M , Blocker H , Dusterhoft A , Kohrer K , Mewes HW , Ottenwalder B |
Ref : Genome Res , 11 :422 , 2001 |
Abstract : Wiemann_2001_Genome.Res_11_422 |
ESTHER : Wiemann_2001_Genome.Res_11_422 |
PubMedSearch : Wiemann_2001_Genome.Res_11_422 |
PubMedID: 11230166 |
Gene_locus related to this paper: human-FAM135A , human-KANSL3 , human-NDRG2 , human-NDRG4 |
Title : Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro - Nagase_2000_DNA.Res_7_65 |
Author(s) : Nagase T , Kikuno R , Ishikawa KI , Hirosawa M , Ohara O |
Ref : DNA Research , 7 :65 , 2000 |
Abstract : Nagase_2000_DNA.Res_7_65 |
ESTHER : Nagase_2000_DNA.Res_7_65 |
PubMedSearch : Nagase_2000_DNA.Res_7_65 |
PubMedID: 10718198 |
Gene_locus related to this paper: human-FAM135A , human-KANSL3 , human-NCEH1 , human-NLGN2 |