human-OLAH
Homo sapiens (Human) s-acyl fatty acid synthase thioesterase, medium chain OLAH THEDC1 SAST (EC 3.1.2.14)
Comment
Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). oleoyl-acyl-carrier-protein hydrolase. S-acyl fatty acid synthase thioesterase, medium chain
Relationship
Molecular evidence
Sequence
Peptide
MERGDQPKRT RNENIFNCLY KNPEATFKLI CFPWMGGGST HFAKWGQDTH DLLEVHSLRL PGRESRVEEP LENDISQLVD EVVCALQPVI QDKPFAFFGH SMGSYIAFRT ALGLKENNQP EPLHLFLSSA TPVHSKAWHR IPKDDELSEE QISHYLMEFG GTPKHFAEAK EFVKQCSPII RADLNIVRSC TSNVPSKAVL SCDLTCFVGS EDIAKDMEAW KDVTSGNAKI YQLPGGHFYL LDPANEKLIK NYIIKCLEVS SISNF
References
| Title : Crystal Structure and Substrate Specificity of Human Thioesterase 2: Insights into the Molecular Basis for the Modulation of Fatty Acid Synthase - Ritchie_2016_J.Biol.Chem_291_3520 |
| Author(s) : Ritchie MK , Johnson LC , Clodfelter JE , Pemble CWt , Fulp BE , Furdui CM , Kridel SJ , Lowther WT |
| Ref : Journal of Biological Chemistry , 291 :3520 , 2016 |
| Abstract : Ritchie_2016_J.Biol.Chem_291_3520 |
| ESTHER : Ritchie_2016_J.Biol.Chem_291_3520 |
| PubMedSearch : Ritchie_2016_J.Biol.Chem_291_3520 |
| PubMedID: 26663084 |
| Gene_locus related to this paper: human-OLAH |
| Title : Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase - Tai_1993_Proc.Natl.Acad.Sci.U.S.A_90_1852 |
| Author(s) : Tai MH , Chirala SS , Wakil SJ |
| Ref : Proc Natl Acad Sci U S A , 90 :1852 , 1993 |
| Abstract : Tai_1993_Proc.Natl.Acad.Sci.U.S.A_90_1852 |
| ESTHER : Tai_1993_Proc.Natl.Acad.Sci.U.S.A_90_1852 |
| PubMedSearch : Tai_1993_Proc.Natl.Acad.Sci.U.S.A_90_1852 |
| PubMedID: 8446599 |
| Gene_locus related to this paper: human-OLAH , ratno-sast |