Rattus norvegicus (Rat) Arylacetamide deacetylase gene (aadac)
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity
MGRTIFLLIS VVLVAYYIYI PLPDDIEEPW KIILGNTLLK LGGDLASFGE LLGLNHFMDT VQLFMRFQVV PPTSDENVTV METDFNSVPV RIYIPKRKST TLRRGLFFIH GGGWCLGSAA YFMYDTLSRR TAHRLDAVVV STDYGLAPKY HFPKQFEDVY HSLRWFLQED ILEKYGVDPR RVGVSGDSAG GNLTAAVTQQ ILQDPDVKIK LKVQALIYPA LQALDMNVPS QQENSQYPLL TRSLLIRFWS EYFTTDRDLE KAMLLNQHVP VEFSHLLQFV NWSSLLPQRY KKGYFYKTPT PGSLELAQKY PGFTDVKACP LLANDSILHH LPMTYIITCQ YDVLRDDGLM YVKRLQNTGV HVTHHHIEDG FHGALTLPGL KITYRMQNQY LNWLHKNL
| Title : Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse - Kobayashi_2012_Drug.Metab.Dispos_40_671 |
| Author(s) : Kobayashi Y , Fukami T , Nakajima A , Watanabe A , Nakajima M , Yokoi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 40 :671 , 2012 |
| Abstract : Kobayashi_2012_Drug.Metab.Dispos_40_671 |
| ESTHER : Kobayashi_2012_Drug.Metab.Dispos_40_671 |
| PubMedSearch : Kobayashi_2012_Drug.Metab.Dispos_40_671 |
| PubMedID: 22207054 |
| Gene_locus related to this paper: human-AADAC , mouse-aryla , ratno-aryla |
| Title : Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation - Trickett_2001_J.Biol.Chem_276_39522 |
| Author(s) : Trickett JI , Patel DD , Knight BL , Saggerson ED , Gibbons GF , Pease RJ |
| Ref : Journal of Biological Chemistry , 276 :39522 , 2001 |
| Abstract : Trickett_2001_J.Biol.Chem_276_39522 |
| ESTHER : Trickett_2001_J.Biol.Chem_276_39522 |
| PubMedSearch : Trickett_2001_J.Biol.Chem_276_39522 |
| PubMedID: 11481320 |
| Gene_locus related to this paper: mouse-aryla , ratno-aryla |