yeast-yfd4

Saccharomyces cerevisiae (Baker's yeast) (strains YJM789; RM11-1a; AWRI1631) Uncharacterized membrane protein Mil1 YFL034W

Comment

The lipase like protein: yeast-yfd4 Mil1(Yfl034w), specifically binds Apm2, one of the adaptor protein of (AP) complexes responsible for binding clathrin, cargo-sorting motifs, accessory factors, and membrane lipids. The paper by Whitfield et al.<\/A> is the first description of a function for a member of the Duf_726<\/A> family. The same protein had been shown to interact with the ribosomal phosphoprotein P0 Aruna et al.<\/A>.. yeast-yfd4 has a conserved catalytic triad || only central part Pfam A DUF726 536 875

Relationship

Family : Duf_726

Block : X

Position in NCBI Life Tree : Saccharomyces cerevisiae

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Sequence

Peptide

MVGGSLVLGL SGGLLAPVIG GGIAAGLSTI GITGATSFLT GVGGTTVVAV SSTAIGANIG ARGMSKRMGS VRTFEFRPLH NNRRVNLILT VSGWMVGNED DVRLPFSTVD PVEGDLYSLY WEPEMLKSIG QTVSIVATEI FTTSLQQILG ATVLTALISS IQWPMALSKL GYILDNPWNV SLDRAWSAGK ILADTLIARN LGARPITLVG FSIGARVIFS CLIELCKKKA LGLIENVYLF GTPAVMKKEQ LVMARSVVSG RFVNGYSDKD WFLAYLFRAA AGGFSAVMGI STIENVEGIE NINCTEFVDG HLNYRKSMPK LLKRIGIAV

References

Title : The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting - Whitfield_2016_Mol.Biol.Cell_27_588
Author(s) : Whitfield ST , Burston HE , Bean BD , Raghuram N , Maldonado-Baez L , Davey M , Wendland B , Conibear E
Ref : Mol Biology of the cell , 27 :588 , 2016
Abstract : Whitfield_2016_Mol.Biol.Cell_27_588
ESTHER : Whitfield_2016_Mol.Biol.Cell_27_588
PubMedSearch : Whitfield_2016_Mol.Biol.Cell_27_588
PubMedID: 26658609
Gene_locus related to this paper: yeast-yfd4

Title : A multidimensional chromatography technology for in-depth phosphoproteome analysis - Albuquerque_2008_Mol.Cell.Proteomics_7_1389
Author(s) : Albuquerque CP , Smolka MB , Payne SH , Bafna V , Eng J , Zhou H
Ref : Mol Cell Proteomics , 7 :1389 , 2008
Abstract : Albuquerque_2008_Mol.Cell.Proteomics_7_1389
ESTHER : Albuquerque_2008_Mol.Cell.Proteomics_7_1389
PubMedSearch : Albuquerque_2008_Mol.Cell.Proteomics_7_1389
PubMedID: 18407956
Gene_locus related to this paper: yeast-YDR428C , yeast-YDR444W , yeast-yfd4

Title : A global topology map of the Saccharomyces cerevisiae membrane proteome - Kim_2006_Proc.Natl.Acad.Sci.U.S.A_103_11142
Author(s) : Kim H , Melen K , Osterberg M , von Heijne G
Ref : Proc Natl Acad Sci U S A , 103 :11142 , 2006
Abstract : Kim_2006_Proc.Natl.Acad.Sci.U.S.A_103_11142
ESTHER : Kim_2006_Proc.Natl.Acad.Sci.U.S.A_103_11142
PubMedSearch : Kim_2006_Proc.Natl.Acad.Sci.U.S.A_103_11142
PubMedID: 16847258
Gene_locus related to this paper: yeast-yfd4

Title : Identification of a hypothetical membrane protein interactor of ribosomal phosphoprotein P0 - Aruna_2004_J.Biosci_29_33
Author(s) : Aruna K , Chakraborty T , Nambeesan S , Mannan AB , Sehgal A , Bhalchandara SR , Sharma S
Ref : J Biosci , 29 :33 , 2004
Abstract : Aruna_2004_J.Biosci_29_33
ESTHER : Aruna_2004_J.Biosci_29_33
PubMedSearch : Aruna_2004_J.Biosci_29_33
PubMedID: 15286401
Gene_locus related to this paper: yeast-yfd4

Title : Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast - Baxter_2004_Mol.Cell.Proteomics_3_209
Author(s) : Baxter SM , Rosenblum JS , Knutson S , Nelson MR , Montimurro JS , Di Gennaro JA , Speir JA , Burbaum JJ , Fetrow JS
Ref : Mol Cell Proteomics , 3 :209 , 2004
Abstract : Baxter_2004_Mol.Cell.Proteomics_3_209
ESTHER : Baxter_2004_Mol.Cell.Proteomics_3_209
PubMedSearch : Baxter_2004_Mol.Cell.Proteomics_3_209
PubMedID: 14645503
Gene_locus related to this paper: yeast-FSH1 , yeast-FSH2 , yeast-FSH3 , yeast-mgll , yeast-ppme1 , yeast-YDR428C , yeast-yfd4 , yeast-YLR118c

Title : Global analysis of protein expression in yeast - Ghaemmaghami_2003_Nature_425_737
Author(s) : Ghaemmaghami S , Huh WK , Bower K , Howson RW , Belle A , Dephoure N , O'Shea EK , Weissman JS
Ref : Nature , 425 :737 , 2003
Abstract : Ghaemmaghami_2003_Nature_425_737
ESTHER : Ghaemmaghami_2003_Nature_425_737
PubMedSearch : Ghaemmaghami_2003_Nature_425_737
PubMedID: 14562106
Gene_locus related to this paper: yeast-AIM2 , yeast-ECM18 , yeast-FSH1 , yeast-FSH2 , yeast-MCFS1 , yeast-MCFS2 , yeast-mgll , yeast-YDL109C , yeast-YDR444W , yeast-yfd4 , yeast-yjg8 , yeast-YLR118c , yeast-yo059 , yeast-YPR147C , yeast-hda1 , yeast-ymc0

Title : Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae - Murakami_1995_Nat.Genet_10_261
Author(s) : Murakami Y , Naitou M , Hagiwara H , Shibata T , Ozawa M , Sasanuma S , Sasanuma M , Tsuchiya Y , Soeda E , Yokoyama K , et al.
Ref : Nat Genet , 10 :261 , 1995
Abstract : Murakami_1995_Nat.Genet_10_261
ESTHER : Murakami_1995_Nat.Genet_10_261
PubMedSearch : Murakami_1995_Nat.Genet_10_261
PubMedID: 7670463
Gene_locus related to this paper: yeast-BST1 , yeast-yfd4