ESTHER Database

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Alignment and mutations

Mutalign

  • help on mutalign and consensus marks
  • With recently described fly mutations (house fly, olive fruit fly, but also danio mutation), for the first time positions not mutated in the aligned sequences are included. Consequently there are positions marqued only by the question mark : 136, 150, 195, 228, 232, 262, 277, 283, 286, 304, 336, 337, 346, 356, 376, 396, 435, 444, 49, 57 .

Mutation viewer

New Applet
                                                 ?   ??? ??   ?    ? ? 
torma-ACHE --------------------------------------DDDSELLVNTKSGKVMRTRIPV 22
torca-ACHE --------------------------------------DDHSELLVNTKSGKVMGTRVPV 22
human-ACHE ------------------------------------EGREDAELLVTVRGGRLRGIRLKT 24
mouse-ACHE ------------------------------------EGREDPQLLVRVRGGQLRGIRLKA 24
bunfa-ACHE -------------------------------------GRAG-ELKVSTQTGSVRGLSLPV 22
human-BCHE ---------------------------------------ED-DIIIATKNGKVRGMNLTV 20
drome-ACHE MAISCRQSRVLPMSLPLPLTIPLPLVLVLSLHLSGVCGVID-RLVVQTSSGPVRGRSVTV 59
consensus                                             : : .  * :    : ..

            ???   ?    ??  ??   ? ?  ??     ???      ?  ? ??????????? ?
torma-ACHE LSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFPGSE 82
torca-ACHE LSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSE 82
human-ACHE PGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTE 84
mouse-ACHE PGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTE 84
bunfa-ACHE LDGHVSAFLGIPFAEPPLGRMRFLRPEPVKPWQHVLDATSYKPACYQMVDTSYPGFQGTE 82
human-BCHE FGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSE 80
drome-ACHE QGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEYFPGFSGEE 119
consensus     : .: ***:*:**:   **  * .   *  : :*:     * *     :*** * *  

           ????  ?  ??   ??  ??                                   ???  
torma-ACHE MWNPNREMSEDCLYLNIWVPS-------------------------------PRPKS--A 109
torca-ACHE MWNPNREMSEDCLYLNIWVPS-------------------------------PRPKS--T 109
human-ACHE MWNPNRELSEDCLYLNVWTPY-------------------------------PRPTSP-T 112
mouse-ACHE MWNPNRELSEDCLYLNVWTPY-------------------------------PRPASP-T 112
bunfa-ACHE MWNPNRGMSEDCLYLNIWVPS-------------------------------PRPKD--A 109
human-BCHE MWNPNTDLSEDCLYLNVWIPA-------------------------------PKPKN--A 107
drome-ACHE IWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGL 179
consensus   .    : .   *.:** *:.     ::. .:::  ::*:*  :***: **:*.  . . *

           ? ??  ?????????  ???????  ???  ?  ?     ?       ?           
torma-ACHE TVMLWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALH------GSQE 163
torca-ACHE TVMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALH------GSQE 163
human-ACHE PVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALP------GSRE 166
mouse-ACHE PVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALP------GSRE 166
bunfa-ACHE PVLVWIYGGGFYSGAASLDVYDGRFLTYTQNVILVSLSYRVGAFGFLGLP------GSPE 163
human-BCHE TVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALP------GNPE 161
drome-ACHE PILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEE 239
consensus   *  . .   :  .  .. * * **:*.  *  **** ** ***:.** **    :*  *.

                   ? ?   ? ? ? ? ?   ? ?? ?   ??? ? ??          ?     ?
torma-ACHE APGNMGLLDQRMALQWVHDNIQFFGGDPKTVTLFGESAGRASVGMHILSPGSRDLFRRAI 223
torca-ACHE APGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGASVGMHILSPGSRDLFRRAI 223
human-ACHE APGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAV 226
mouse-ACHE APGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAV 226
bunfa-ACHE APGNMGLLDQRLALQWIQNNIHPFGGNPRAVTVFGESAGAASVGMHLLSTQSRTLFQRAI 223
human-BCHE APGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAI 221
drome-ACHE APGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGM 299
consensus    :.: ::     **: *:* :  .     ** :.     :  :.            .  *

             ???? ??? ?????     ??   ? ?  ? ??????   ?     ?? ? ?  ????
torma-ACHE LQSGSPNCPWASVSVAEGRRRAVELRRNLNCNLN----SDEDLIQCLREKKPQELIDVEW 279
torca-ACHE LQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLN----SDEELIHCLREKKPQELIDVEW 279
human-ACHE LQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEW 286
mouse-ACHE LQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELIACLRTRPAQDLVDHEW 286
bunfa-ACHE LQSGGPNAPWATVTPAESRGRAALLGKQLGCHFN----NDSELVSCLRSKNPQELIDEEW 279
human-BCHE LQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRE----NETEIIKCLRNKDPQEILLNEA 277
drome-ACHE MQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQW 359
consensus    **. ::**: . :

           ? ?????????? ?  ?     ? ? ?? ? ?  ?? ??    ?  ??????? ????  
torma-ACHE NVLPFDSIFRFSFVPVIDGEFFPTSLESMLNAGNFKKTQILLGVNKDEGSFFLLYGAPG- 338
torca-ACHE NVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGVNKDEGSFFLLYGAPG- 338
human-ACHE HVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPG- 345
mouse-ACHE HVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPG- 345
bunfa-ACHE SVLPYKSIFRFPFVPVIDGDFFPDTPEAMLSSGNFKETQVLLGVVKDEGSYFLIYGLPG- 338
human-BCHE FVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPG- 336
drome-ACHE N--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDY 417
consensus   

             ???? ??  ??  ? ? ?   ?  ???   ?    ?  ? ???  ????  ?  ??? 
torma-ACHE FSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDH 398
torca-ACHE FSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDH 398
human-ACHE FSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDH 405
mouse-ACHE FSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDH 405
bunfa-ACHE FSKDNESLISRADFLEGVRMSVPHANDIATDAVVLQYTDWQDQDNREKNREALDDIVGDH 398
human-BCHE FSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDY 396
drome-ACHE FDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEG-NPGYQNQQQIGRAVGDH 476
consensus   

           ????    ??? ?? ? ?  ???  ????   ?? ???  ???????  ?    ?  ?? 
torma-ACHE NVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNY 458
torca-ACHE NVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYEIEFVFGLPLVKELNY 458
human-ACHE NVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNY 465
mouse-ACHE NVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNY 465
bunfa-ACHE NVICPVVQFANDYAKRNSKVYAYLFDHRASNLLWPPWMGVPHGYEIEFVFGLPLNDSLNY 458
human-BCHE NFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNY 456
drome-ACHE FFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQY 536
consensus   

            ?? ?   ?? ????  ?      ?     ?  ??   ????  ?   ?     ?     
torma-ACHE TAEEEALSRRIMHYWATFAKTGNPNEPHS-QESKWPLFTTKEQKFIDLNTEP--IKVHQR 515
torca-ACHE TAEEEALSRRIMHYWATFAKTGNPNEPHS-QESKWPLFTTKEQKFIDLNTEP--MKVHQR 515
human-ACHE TAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRP--LEVRRG 523
mouse-ACHE TTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKP--LEVRRG 523
bunfa-ACHE TPQEKELSRRMMRYWANFARTGNPTDPAD-KSGAWPTYTASQPQYVQLNTQP--LATQPS 515
human-BCHE TKAEEILSRSIVKRWANFAKYGNPNETQN-NSTSWPVFKSTEQKYLTLNTES--TRIMTK 513
drome-ACHE RPVERELGKRMLSAVIEFAKTGNPAQDGE----EWPNFSKEDPVYYIFSTDDKIEKLARG 592
consensus   

            ?? ?  ???????? ??? 
torma-ACHE LRVQMCVFWNQFLPKLLNAT 535
torca-ACHE LRVQMCVFWNQFLPKLLNAT 535
human-ACHE LRAQACAFWNRFLPKLLSAT 543
mouse-ACHE LRAQTCAFWNRFLPKLLSAT 543
bunfa-ACHE LRAQICAFWNHFLPKLLNAT 535
human-BCHE LRAQQCRFWTSFFPKVLEMT 533
drome-ACHE PLAARCSFWNDYLPKVRSWA 612
consensus   

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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Acknowledgements and disclaimer