4-aminocyclohexylalanine-derivative-25
alpha amino acid inhibitor
General
Type : Pyrrolidine
Chemical_Nomenclature : N-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]cyclohexyl]-N-methylacetamide
Canonical SMILES : CC(C1CCC(CC1)N(C)C(=O)C)C(C(=O)N2CCC(C2)F)N
InChI : InChI=1S\/C17H30FN3O2\/c1-11(16(19)17(23)21-9-8-14(18)10-21)13-4-6-15(7-5-13)20(3)12(2)22\/h11,13-16H,4-10,19H2,1-3H3\/t11-,13?,14-,15?,16-\/m0\/s1
InChIKey : BZFQBRSDORUYAB-IZMWZWCESA-N
Other name(s) : 277,N-(Trans-4-{(1s,2s)-2-Amino-3-[(3s)-3-Fluoropyrrolidin-1-Yl]-1-Methyl-3-Oxopropyl}cyclohexyl)-N-Methylacetamide,CHEMBL1182555,CHEMBL1229855,SCHEMBL13412200,BDBM17323,DB06939
MW : 327.44
Formula : C17H30FN3O2
CAS_number :
PubChem : 16122596
UniChem : BZFQBRSDORUYAB-IZMWZWCESA-N
IUPHAR :
Wikipedia :
Target
Families : 4-aminocyclohexylalanine-derivative-25 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 2OPH Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor
Protein : human-DPP4
References (1)
| Title : 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV - Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| Author(s) : Duffy JL , Kirk BA , Wang L , Eiermann GJ , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2879 , 2007 |
| Abstract : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| ESTHER : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| PubMedSearch : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| PubMedID: 17350841 |
| Gene_locus related to this paper: human-DPP4 |