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Inhibitor Report for: 64D

Monoacylglycerol lipase (human-MGLL) inhibitor


General
Type Piperidine, PET probe, Sulfonyl, Sulfur Compound
Chemical_Nomenclature 4-[[(4-chlorophenyl)sulfonylamino]methyl]piperidine-1-carboxylic acid
Canonical SMILES C1CN(CCC1CNS(=O)(=O)C2=CC=C(C=C2)Cl)C(=O)O
InChI InChI=1S/C13H17ClN2O4S/c14-11-1-3-12(4-2-11)21(19,20)15-9-10-5-7-16(8-6-10)13(17)18/h1-4,10,15H,5-9H2,(H,17,18)
InChIKey CFNWARLITZSZQR-UHFFFAOYSA-N
Other name(s) SAR127303 ; [11C]SAR127303 ; SCHEMBL14834137 ; 4-({[(4-Chlorophenyl)sulfonyl]amino}methyl)piperidine-1-Carboxylic Acid
________________________________________________________________________________________________
MW|332.80
Formula|C13H17ClN2O4S
CAS_number|
PubChem|86580387
UniChem|CFNWARLITZSZQR-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | 64D ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture | 1 structure: 4UUQ: Crystal structure of human mono-glyceride lipase in complex with SAR127303
Protein | human-MGLL

References:
Search PubMed for references concerning: 64D
    Title: First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [(11)C]SAR127303
    Yamasaki T, Mori W, Zhang Y, Hatori A, Fujinaga M, Wakizaka H, Kurihara Y, Wang L, Nengaki N and Zhang MR <2 more author(s)>
    Ref: Neuroimage, 176:313, 2018 : PubMed

            

    Title: Monoglyceride lipase: Structure and inhibitors
    Scalvini L, Piomelli D, Mor M
    Ref: Chemistry & Physic of Lipids, 197:13, 2016 : PubMed

            

    Title: Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents
    Griebel G, Pichat P, Beeske S, Leroy T, Redon N, Jacquet A, Francon D, Bert L, Even L and Escoubet J <21 more author(s)>
    Ref: Sci Rep, 5:7642, 2015 : PubMed