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Inhibitor Report for: 6AX1-cp3

Oxadiazole 3-substituted azetidine carbamate IC50 0.38nM for MGLL


General
Type Halo ketone, Trifluoro, Carbamate, Azetidin, Oxadiazol
Chemical_Nomenclature 1,1,1,3,3,3-Hexafluoropropan-2-yl 3-(3-Phenyl-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate
Canonical SMILES FC(F)(F)C(OC(=O)N1CC(C1)c1nc(no1)-c1ccccc1)C(F)(F)F
InChI InChI=1S/C15H11F6N3O3/c16-14(17,18)12(15(19,20)21)26-13(25)24-6-9(7-24)11-22-10(23-27-11)8-4-2-1-3-5-8/h1-5,9,12H,6-7H2
InChIKey MQSOFDLFKHBDFY-UHFFFAOYSA-N
Other name(s) CHEMBL4089505 ; C0S
________________________________________________________________________________________________
MW|395.26
Formula|C15H11F6N3O3
CAS_number|
PubChem|137349039
UniChem|MQSOFDLFKHBDFY-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | 6AX1-cp3 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture | 1 structure: 6AX1: Structure of human monoacylglycerol lipase bound to a covalent inhibitor
Protein | human-MGLL

References:
Search PubMed for references concerning: 6AX1-cp3
    Title: Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase
    Butler CR, Beck EM, Harris A, Huang Z, McAllister LA, Am Ende CW, Fennell K, Foley TL, Fonseca K and Brodney MA <12 more author(s)>
    Ref: Journal of Medicinal Chemistry, 60:9860, 2017 : PubMed