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Inhibitor Report for: 6M08-BWL

General
Type Trifluoro, Pyrrolidine
Chemical_Nomenclature (2S)-2-[(Z)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]amino]-1-hydroxy-3-oxoprop-1-enyl]pyrrolidine-1-carboxylic acid
Canonical SMILES CCN(CC)CCN(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)C(=O)C=C(C3CCCN3C(=O)O)O
InChI InChI=1S/C28H34F3N3O4/c1-3-32(4-2)16-17-33(26(36)18-25(35)24-6-5-15-34(24)27(37)38)19-20-7-9-21(10-8-20)22-11-13-23(14-12-22)28(29,30)31/h7-14,18,24,35H,3-6,15-17,19H2,1-2H3,(H,37,38)/b25-18-/t24-/m0/s1
InChIKey GTFYUFYLBSPPRI-BUFPPZMGSA-N
Other name(s) (2S)-2-[(Z)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]amino]-1-oxidanyl-3-oxidanylidene-prop-1-enyl]pyrrolidine-1-carboxylic acid ; (Z)-N-[2-(diethylamino)ethyl]-3-[(2S)-1-methanoylpyrrolidin-2-yl]-3-oxidanyl-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]prop-2-enamide ; BWL ; Compound 7
________________________________________________________________________________________________
MW|533.6
Formula|C28H34F3N3O4
CAS_number|
PubChem|155289216
UniChem|GTFYUFYLBSPPRI-BUFPPZMGSA-N
IUPHAR|
Wikipedia|

Target
Families | 6M08-BWL ligand of proteins in family: PAF-Acetylhydrolase
Stucture | 1 structure: 6M08: Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M08-BWO compound 7
Protein | human-PLA2G7

References:
Search PubMed for references concerning: 6M08-BWL
    Title: Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach
    Huang F, Hu H, Wang K, Peng C, Xu W, Zhang Y, Gao J, Liu Y, Zhou H and Xu Y <3 more author(s)>
    Ref: Journal of Medicinal Chemistry, 63:7052, 2020 : PubMed