carbamate-based inhibitor AM9928 (hMAGL IC(50) 9 nM) with prolonged pharmacodynamic effects (46 h of target residence time) (ratFAAH IC50 27 nM)
Type : Piperazine,Fluoren,Carbamate
Chemical_Nomenclature :
Canonical SMILES : C1=CC=CC2=C1C5=C(C2N3CCN(CC3)C(=O)OC4=NC=CC(=C4)O)C=CC=C5
InChI : InChI=1S\/C23H21N3O3\/c27-16-9-10-24-21(15-16)29-23(28)26-13-11-25(12-14-26)22-19-7-3-1-5-17(19)18-6-2-4-8-20(18)22\/h1-10,15,22H,11-14H2,(H,24,27)
InChIKey : RZYJWDRANGBBLS-UHFFFAOYSA-N
Other name(s) : AM-9928,(4-hydroxy-2-yl) 4-(9H-fluoren-9-yl)piperazine-1-carboxylate
MW : 387.43
Formula : C23H21N3O3
CAS_number :
PubChem :
UniChem : RZYJWDRANGBBLS-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : AM9928 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture :
Protein : human-MGLL
Title : Inhibition of triple negative breast cancer-associated inflammation, tumor growth and brain colonization by targeting monoacylglycerol lipase - Benchama_2022_Sci.Rep_12_5328 |
Author(s) : Benchama O , Tyukhtenko S , Malamas MS , Williams MK , Makriyannis A , Avraham HK |
Ref : Sci Rep , 12 :5328 , 2022 |
Abstract : Benchama_2022_Sci.Rep_12_5328 |
ESTHER : Benchama_2022_Sci.Rep_12_5328 |
PubMedSearch : Benchama_2022_Sci.Rep_12_5328 |
PubMedID: 35351947 |
Gene_locus related to this paper: human-MGLL |