Ala(1-naph)-Pro-CN
Ala(1-naph)-Pro-CN is reported to inhibit the putative hydrolase RBBP9 and dipeptidyl-peptidase 4 (DPP4)
General
Type : Peptide,Pyrrolidine,Naphthalen
Chemical_Nomenclature : (2S)-1-[(2S)-2-amino-3-naphthalen-1-ylpropanoyl]pyrrolidine-2-carbonitrile
Canonical SMILES : C1CC(N(C1)C(=O)C(CC2=CC=CC3=CC=CC=C32)N)C#N
InChI : InChI=1S\/C18H19N3O\/c19-12-15-8-4-10-21(15)18(22)17(20)11-14-7-3-6-13-5-1-2-9-16(13)14\/h1-3,5-7,9,15,17H,4,8,10-11,20H2\/t15-,17-\/m0\/s1
InChIKey : ZVRWNKCHASBEDZ-RDJZCZTQSA-N
Other name(s) : GTPL8607
MW : 293.36
Formula : C18H19N3O
CAS_number :
PubChem : 74765859
UniChem : ZVRWNKCHASBEDZ-RDJZCZTQSA-N
IUPHAR : 8607
Wikipedia :
-Pro-CN.gif)
Target
Families : Ala(1-naph)-Pro-CN ligand of proteins in family: Hydrolase_RBBP9_YdeN || DPP4N_Peptidase_S9
Stucture :
Protein : human-RBBP9 || human-DPP4
References (1)
| Title : A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity - Bachovchin_2014_Nat.Chem.Biol_10_656 |
| Author(s) : Bachovchin DA , Koblan LW , Wu W , Liu Y , Li Y , Zhao P , Woznica I , Shu Y , Lai JH , Poplawski SE , Kiritsy CP , Healey SE , DiMare M , Sanford DG , Munford RS , Bachovchin WW , Golub TR |
| Ref : Nat Chemical Biology , 10 :656 , 2014 |
| Abstract : Bachovchin_2014_Nat.Chem.Biol_10_656 |
| ESTHER : Bachovchin_2014_Nat.Chem.Biol_10_656 |
| PubMedSearch : Bachovchin_2014_Nat.Chem.Biol_10_656 |
| PubMedID: 24997602 |
| Gene_locus related to this paper: human-PPME1 |