Aromatic-tertiary-amine-17c
IC50 eqBChE 0.22 +/- 0.018 microM, IC50 human-BCHE 0.016 +/- 0.006 microM
General
Type : Naphthalen,Carboxamide
Chemical_Nomenclature : N-(2-methylphenyl)-2-[2-methylpropyl(naphthalen-2-ylmethyl)amino]acetamide
Canonical SMILES : CC1=CC=CC=C1NC(=O)CN(CC2=CC3=CC=CC=C3C=C2)CC(C)C
InChI : InChI=1S\/C24H28N2O\/c1-18(2)15-26(17-24(27)25-23-11-7-4-8-19(23)3)16-20-12-13-21-9-5-6-10-22(21)14-20\/h4-14,18H,15-17H2,1-3H3,(H,25,27)
InChIKey : ULIOAMNTKXKLNZ-UHFFFAOYSA-N
Other name(s) : 2-(isobutyl (naphthalen-2-ylmethyl)amino)-N-(o-tolyl)acetamide, 17c
MW : 360.5
Formula : C24H28N2O
CAS_number :
PubChem : 156786229
UniChem : ULIOAMNTKXKLNZ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Aromatic-tertiary-amine-17c ligand of proteins in family: BCHE
Stucture :
Protein : human-BCHE
References (1)
| Title : Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease - Lu_2022_Eur.J.Med.Chem_243_114729 |
| Author(s) : Lu X , Qin N , Liu Y , Du C , Feng F , Liu W , Chen Y , Sun H |
| Ref : Eur Journal of Medicinal Chemistry , 243 :114729 , 2022 |
| Abstract : Lu_2022_Eur.J.Med.Chem_243_114729 |
| ESTHER : Lu_2022_Eur.J.Med.Chem_243_114729 |
| PubMedSearch : Lu_2022_Eur.J.Med.Chem_243_114729 |
| PubMedID: 36084535 |