Berberine
Berberine is a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs (goldenseal, barberry and Oregon grape)It has a role as an antilipemic drug, a hypoglycemic agent, an antioxidant, a potassium channel blocker, an antineoplastic agent. It inhibits enzymes including: aldehyde reductase; [15-hydroxyprostaglandin dehydrogenase (NAD(+))]; indoleamine 2,3-dioxygenase; reticuline oxidase; [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase]; phospholipase A2; prolyl oligopeptidase; dipeptidyl-peptidase IV; protein-tyrosine-phosphatase; acetylcholinesterase; butyrylcholinesterase; IkappaB kinase. || . IC50 human-ACHE 0.1 muM eleel 0.374 human-BCHE 1.09 muM.
General
Type : Natural,Alkaloid,Not A\/B H target,Isoquinoline,Benzodioxo
Chemical_Nomenclature : 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene
Canonical SMILES : COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC
InChI : InChI=1S\/C20H18NO4\/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2\/h3-4,7-10H,5-6,11H2,1-2H3\/q+1
InChIKey : YBHILYKTIRIUTE-UHFFFAOYSA-N
Other name(s) : Umbellatine,Berberin,Berbericine,CHEBI:16118,Berberal,CHEMBL12089,ZINC3779067,CHEMBL295124,DB-050153,Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-,9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium
MW : 336.4
Formula : C20H18NO4+
CAS_number : 2086-83-1
PubChem : 2353
UniChem : YBHILYKTIRIUTE-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (45)
| Title : Berberine modulates crucial erectogenic biomolecules and alters histological architecture in penile tissues of diabetic rats - Adefegha_2021_Andrologia__e14074 |
| Author(s) : Adefegha SA , Oboh G , Dada FA , Oyeleye SI , Okeke BM |
| Ref : Andrologia , :e14074 , 2021 |
| Abstract : Adefegha_2021_Andrologia__e14074 |
| ESTHER : Adefegha_2021_Andrologia__e14074 |
| PubMedSearch : Adefegha_2021_Andrologia__e14074 |
| PubMedID: 33930193 |
| Title : Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats - Adefegha_2021_J.Basic.Clin.Physiol.Pharmacol__ |
| Author(s) : Adefegha SA , Dada FA , Oyeleye SI , Oboh G |
| Ref : J Basic Clin Physiol Pharmacol , : , 2021 |
| Abstract : Adefegha_2021_J.Basic.Clin.Physiol.Pharmacol__ |
| ESTHER : Adefegha_2021_J.Basic.Clin.Physiol.Pharmacol__ |
| PubMedSearch : Adefegha_2021_J.Basic.Clin.Physiol.Pharmacol__ |
| PubMedID: 33725758 |
| Title : Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine - Adefegha_2021_J.Complement.Integr.Med__ |
| Author(s) : Adefegha SA , Oboh G , Okeke BM |
| Ref : J Complement Integr Med , : , 2021 |
| Abstract : Adefegha_2021_J.Complement.Integr.Med__ |
| ESTHER : Adefegha_2021_J.Complement.Integr.Med__ |
| PubMedSearch : Adefegha_2021_J.Complement.Integr.Med__ |
| PubMedID: 33544523 |
| Title : Berberine Nanoencapsulation Attenuates Hallmarks of Scoplomine Induced Alzheimer's-Like Disease in Rats - Saleh_2021_Curr.Rev.Clin.Exp.Pharmacol_16_139 |
| Author(s) : Saleh SR , Abady MM , Nofal M , Yassa NW , Abdel-Latif MS , Nounou MI , Ghareeb DA , Abdel-Monaem N |
| Ref : Curr Rev Clin Exp Pharmacol , 16 :139 , 2021 |
| Abstract : Saleh_2021_Curr.Rev.Clin.Exp.Pharmacol_16_139 |
| ESTHER : Saleh_2021_Curr.Rev.Clin.Exp.Pharmacol_16_139 |
| PubMedSearch : Saleh_2021_Curr.Rev.Clin.Exp.Pharmacol_16_139 |
| PubMedID: 32598269 |
| Title : Berberine Ameliorates Glucose Metabolism in Diabetic Rats through the alpha7 Nicotinic Acetylcholine Receptor-Related Cholinergic Anti-Inflammatory Pathway - Wang_2021_Planta.Med__ |
| Author(s) : Wang D , Ren Y , Sun W , Gong J , Zou X , Dong H , Xu L , Wang K , Lu F |
| Ref : Planta Med , : , 2021 |
| Abstract : Wang_2021_Planta.Med__ |
| ESTHER : Wang_2021_Planta.Med__ |
| PubMedSearch : Wang_2021_Planta.Med__ |
| PubMedID: 33682914 |
| Title : Binding interaction of protoberberine alkaloids against acetylcholinesterase (AChE) using molecular dynamics simulations and QM\/MM calculations - Honorio_2021_Chem.Biol.Interact__109523 |
| Author(s) : Honorio P , Sainimnuan S , Hannongbua S , Saparpakorn P |
| Ref : Chemico-Biological Interactions , :109523 , 2021 |
| Abstract : Honorio_2021_Chem.Biol.Interact__109523 |
| ESTHER : Honorio_2021_Chem.Biol.Interact__109523 |
| PubMedSearch : Honorio_2021_Chem.Biol.Interact__109523 |
| PubMedID: 34033838 |
| Title : Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on beta-amyloid aggregation - Marasco_2021_Chem.Biol.Interact_334_109300 |
| Author(s) : Marasco D , Vicidomini C , Krupa P , Cioffi F , Huy PDQ , Li MS , Florio D , Broersen K , De Pandis MF , Roviello GN |
| Ref : Chemico-Biological Interactions , 334 :109300 , 2021 |
| Abstract : Marasco_2021_Chem.Biol.Interact_334_109300 |
| ESTHER : Marasco_2021_Chem.Biol.Interact_334_109300 |
| PubMedSearch : Marasco_2021_Chem.Biol.Interact_334_109300 |
| PubMedID: 33098838 |
| Title : Molecular dynamics investigation of the interaction between Colletotrichum capsici cutinase and berberine suggested a mechanism for reduced enzyme activity - Li_2021_PLoS.One_16_e0247236 |
| Author(s) : Li Y , Wei J , Yang H , Dai J , Ge X |
| Ref : PLoS ONE , 16 :e0247236 , 2021 |
| Abstract : Li_2021_PLoS.One_16_e0247236 |
| ESTHER : Li_2021_PLoS.One_16_e0247236 |
| PubMedSearch : Li_2021_PLoS.One_16_e0247236 |
| PubMedID: 33606796 |
| Title : A review on pain-relieving activity of berberine - Hashemzaei_2020_Phytother.Res__ |
| Author(s) : Hashemzaei M , Rezaee R |
| Ref : Phytother Res , : , 2020 |
| Abstract : Hashemzaei_2020_Phytother.Res__ |
| ESTHER : Hashemzaei_2020_Phytother.Res__ |
| PubMedSearch : Hashemzaei_2020_Phytother.Res__ |
| PubMedID: 33340158 |
| Title : Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile - Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| Author(s) : Sobolova K , Hrabinova M , Hepnarova V , Kucera T , Kobrlova T , Benkova M , Janockova J , Dolezal R , Prchal L , Benek O , Mezeiova E , Jun D , Soukup O , Korabecny J |
| Ref : Eur Journal of Medicinal Chemistry , 203 :112593 , 2020 |
| Abstract : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| ESTHER : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| PubMedSearch : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| PubMedID: 32688201 |
| Title : In vitro and in silico studies of the larvicidal and anticholinesterase activities of berberine and piperine alkaloids on Rhipicephalus microplus - da Silva_2020_Ticks.Tick.Borne.Dis_12_101643 |
| Author(s) : da Silva GD , de Lima HG , de Freitas HF , da Rocha Pita SS , Dos Santos Luz Y , de Figueiredo MP , Uzeda RS , Branco A , Costa SL , Batatinha MJM , Botura MB |
| Ref : Ticks Tick Borne Dis , 12 :101643 , 2020 |
| Abstract : da Silva_2020_Ticks.Tick.Borne.Dis_12_101643 |
| ESTHER : da Silva_2020_Ticks.Tick.Borne.Dis_12_101643 |
| PubMedSearch : da Silva_2020_Ticks.Tick.Borne.Dis_12_101643 |
| PubMedID: 33388555 |
| Title : Berberine ameliorates lipopolysaccharide-induced learning and memory deficit in the rat: insights into underlying molecular mechanisms - Sadraie_2019_Metab.Brain.Dis_34_245 |
| Author(s) : Sadraie S , Kiasalari Z , Razavian M , Azimi S , Sedighnejad L , Afshin-Majd S , Baluchnejadmojarad T , Roghani M |
| Ref : Metabolic Brain Disease , 34 :245 , 2019 |
| Abstract : Sadraie_2019_Metab.Brain.Dis_34_245 |
| ESTHER : Sadraie_2019_Metab.Brain.Dis_34_245 |
| PubMedSearch : Sadraie_2019_Metab.Brain.Dis_34_245 |
| PubMedID: 30456649 |
| Title : Synthesis and Inhibition Evaluation of New Benzyltetrahydroprotoberberine Alkaloids Designed as Acetylcholinesterase Inhibitors - de Lima_2019_Front.Chem_7_629 |
| Author(s) : de Lima BR , Lima JM , Maciel JB , Valentim CQ , Nunomura RCS , Lima ES , Koolen HHF , de Souza ADL , Pinheiro MLB , Cass QB , da Silva FMA |
| Ref : Front Chem , 7 :629 , 2019 |
| Abstract : de Lima_2019_Front.Chem_7_629 |
| ESTHER : de Lima_2019_Front.Chem_7_629 |
| PubMedSearch : de Lima_2019_Front.Chem_7_629 |
| PubMedID: 31620424 |
| Title : Berberine Ameliorates Spatial Learning Memory Impairment and Modulates Cholinergic Anti-Inflammatory Pathway in Diabetic Rats - Wang_2019_Front.Pharmacol_10_1003 |
| Author(s) : Wang K , Chen Q , Wu N , Li Y , Zhang R , Wang J , Gong D , Zou X , Liu C , Chen J |
| Ref : Front Pharmacol , 10 :1003 , 2019 |
| Abstract : Wang_2019_Front.Pharmacol_10_1003 |
| ESTHER : Wang_2019_Front.Pharmacol_10_1003 |
| PubMedSearch : Wang_2019_Front.Pharmacol_10_1003 |
| PubMedID: 31551793 |
| Title : Neuroprotective effects of berberine in animal models of Alzheimer's disease: a systematic review of pre-clinical studies - Yuan_2019_BMC.Complement.Altern.Med_19_109 |
| Author(s) : Yuan NN , Cai CZ , Wu MY , Su HX , Li M , Lu JH |
| Ref : BMC Complement Altern Med , 19 :109 , 2019 |
| Abstract : Yuan_2019_BMC.Complement.Altern.Med_19_109 |
| ESTHER : Yuan_2019_BMC.Complement.Altern.Med_19_109 |
| PubMedSearch : Yuan_2019_BMC.Complement.Altern.Med_19_109 |
| PubMedID: 31122236 |
| Title : Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via Sirt1\/p38 MAPK expression - Wang_2018_Mol.Med.Rep_17_6881 |
| Author(s) : Wang J , Zhang Y |
| Ref : Mol Med Rep , 17 :6881 , 2018 |
| Abstract : Wang_2018_Mol.Med.Rep_17_6881 |
| ESTHER : Wang_2018_Mol.Med.Rep_17_6881 |
| PubMedSearch : Wang_2018_Mol.Med.Rep_17_6881 |
| PubMedID: 29512719 |
| Title : Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death - de Oliveira_2016_Neurotoxicol_57_241 |
| Author(s) : de Oliveira JS , Abdalla FH , Dornelles GL , Adefegha SA , Palma TV , Signor C , da Silva Bernardi J , Baldissarelli J , Lenz LS , Magni LP , Rubin MA , Pillat MM , de Andrade CM |
| Ref : Neurotoxicology , 57 :241 , 2016 |
| Abstract : de Oliveira_2016_Neurotoxicol_57_241 |
| ESTHER : de Oliveira_2016_Neurotoxicol_57_241 |
| PubMedSearch : de Oliveira_2016_Neurotoxicol_57_241 |
| PubMedID: 27746125 |
| Title : Molecular Modeling on Berberine Derivatives toward BuChE: An Integrated Study with Quantitative Structure-Activity Relationships Models, Molecular Docking, and Molecular Dynamics Simulations - Fang_2016_Chem.Biol.Drug.Des_87_649 |
| Author(s) : Fang J , Pang X , Wu P , Yan R , Gao L , Li C , Lian W , Wang Q , Liu AL , Du GH |
| Ref : Chemical Biology Drug Des , 87 :649 , 2016 |
| Abstract : Fang_2016_Chem.Biol.Drug.Des_87_649 |
| ESTHER : Fang_2016_Chem.Biol.Drug.Des_87_649 |
| PubMedSearch : Fang_2016_Chem.Biol.Drug.Des_87_649 |
| PubMedID: 26648584 |
| Title : Berberine relieves insulin resistance via the cholinergic anti-inflammatory pathway in HepG2 cells - Li_2016_J.Huazhong.Univ.Sci.Technolog.Med.Sci_36_64 |
| Author(s) : Li F , Zhao YB , Wang DK , Zou X , Fang K , Wang KF |
| Ref : J Huazhong Univ Sci Technolog Med Sci , 36 :64 , 2016 |
| Abstract : Li_2016_J.Huazhong.Univ.Sci.Technolog.Med.Sci_36_64 |
| ESTHER : Li_2016_J.Huazhong.Univ.Sci.Technolog.Med.Sci_36_64 |
| PubMedSearch : Li_2016_J.Huazhong.Univ.Sci.Technolog.Med.Sci_36_64 |
| PubMedID: 26838742 |
| Title : Protective effect of berberine, an isoquinoline alkaloid ameliorates ethanol-induced oxidative stress and memory dysfunction in rats - Patil_2015_Pharmacol.Biochem.Behav_136_13 |
| Author(s) : Patil S , Tawari S , Mundhada D , Nadeem S |
| Ref : Pharmacol Biochem Behav , 136 :13 , 2015 |
| Abstract : Patil_2015_Pharmacol.Biochem.Behav_136_13 |
| ESTHER : Patil_2015_Pharmacol.Biochem.Behav_136_13 |
| PubMedSearch : Patil_2015_Pharmacol.Biochem.Behav_136_13 |
| PubMedID: 26159088 |
| Title : Isolation of cholinesterase and beta-secretase 1 inhibiting compounds from Lycopodiella cernua - Nguyen_2015_Bioorg.Med.Chem_23_3126 |
| Author(s) : Nguyen VT , To DC , Tran MH , Oh SH , Kim JA , Ali MY , Woo MH , Choi JS , Min BS |
| Ref : Bioorganic & Medicinal Chemistry , 23 :3126 , 2015 |
| Abstract : Nguyen_2015_Bioorg.Med.Chem_23_3126 |
| ESTHER : Nguyen_2015_Bioorg.Med.Chem_23_3126 |
| PubMedSearch : Nguyen_2015_Bioorg.Med.Chem_23_3126 |
| PubMedID: 26003344 |
| Title : The therapeutic potential of berberine against the altered intrinsic properties of the CA1 neurons induced by Abeta neurotoxicity - Haghani_2015_Eur.J.Pharmacol_758_82 |
| Author(s) : Haghani M , Shabani M , Tondar M |
| Ref : European Journal of Pharmacology , 758 :82 , 2015 |
| Abstract : Haghani_2015_Eur.J.Pharmacol_758_82 |
| ESTHER : Haghani_2015_Eur.J.Pharmacol_758_82 |
| PubMedSearch : Haghani_2015_Eur.J.Pharmacol_758_82 |
| PubMedID: 25861937 |
| Title : Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from chinese medicinal herbs - Mak_2014_J.Mol.Neurosci_53_511 |
| Author(s) : Mak SH , Luk WW , Cui W , Hu S , Tsim KWK , Han Y |
| Ref : Journal of Molecular Neuroscience , 53 :511 , 2014 |
| Abstract : Mak_2014_J.Mol.Neurosci_53_511 |
| ESTHER : Mak_2014_J.Mol.Neurosci_53_511 |
| PubMedSearch : Mak_2014_J.Mol.Neurosci_53_511 |
| PubMedID: 24793543 |
| Title : Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia - Singh_2013_Eur.J.Pharmacol_720_98 |
| Author(s) : Singh DP , Chopra K |
| Ref : European Journal of Pharmacology , 720 :98 , 2013 |
| Abstract : Singh_2013_Eur.J.Pharmacol_720_98 |
| ESTHER : Singh_2013_Eur.J.Pharmacol_720_98 |
| PubMedSearch : Singh_2013_Eur.J.Pharmacol_720_98 |
| PubMedID: 24177287 |
| Title : In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects - Abd_2013_BMC.Complement.Altern.Med_13_218 |
| Author(s) : Abd El-Wahab AE , Ghareeb DA , Sarhan EE , Abu-Serie MM , El Demellawy MA |
| Ref : BMC Complement Altern Med , 13 :218 , 2013 |
| Abstract : Abd_2013_BMC.Complement.Altern.Med_13_218 |
| ESTHER : Abd_2013_BMC.Complement.Altern.Med_13_218 |
| PubMedSearch : Abd_2013_BMC.Complement.Altern.Med_13_218 |
| PubMedID: 24007270 |
| Title : Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids - Huang_2012_Bioorg.Med.Chem_20_3038 |
| Author(s) : Huang L , Su T , Shan W , Luo Z , Sun Y , He F , Li X |
| Ref : Bioorganic & Medicinal Chemistry , 20 :3038 , 2012 |
| Abstract : Huang_2012_Bioorg.Med.Chem_20_3038 |
| ESTHER : Huang_2012_Bioorg.Med.Chem_20_3038 |
| PubMedSearch : Huang_2012_Bioorg.Med.Chem_20_3038 |
| PubMedID: 22472046 |
| Title : Molecular basis of inhibitory activities of berberine against pathogenic enzymes in Alzheimer's disease - Ji_2012_ScientificWorldJournal_2012_823201 |
| Author(s) : Ji HF , Shen L |
| Ref : ScientificWorldJournal , 2012 :823201 , 2012 |
| Abstract : Ji_2012_ScientificWorldJournal_2012_823201 |
| ESTHER : Ji_2012_ScientificWorldJournal_2012_823201 |
| PubMedSearch : Ji_2012_ScientificWorldJournal_2012_823201 |
| PubMedID: 22262957 |
| Title : Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells - Zhu_2011_BMC.Neurosci_12_125 |
| Author(s) : Zhu F , Wu F , Ma Y , Liu G , Li Z , Sun Y , Pei Z |
| Ref : BMC Neurosci , 12 :125 , 2011 |
| Abstract : Zhu_2011_BMC.Neurosci_12_125 |
| ESTHER : Zhu_2011_BMC.Neurosci_12_125 |
| PubMedSearch : Zhu_2011_BMC.Neurosci_12_125 |
| PubMedID: 22152059 |
| Title : Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes - Bhutada_2011_Behav.Brain.Res_220_30 |
| Author(s) : Bhutada P , Mundhada Y , Bansod K , Tawari S , Patil S , Dixit P , Umathe S , Mundhada D |
| Ref : Behavioural Brain Research , 220 :30 , 2011 |
| Abstract : Bhutada_2011_Behav.Brain.Res_220_30 |
| ESTHER : Bhutada_2011_Behav.Brain.Res_220_30 |
| PubMedSearch : Bhutada_2011_Behav.Brain.Res_220_30 |
| PubMedID: 21262264 |
| Title : Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease - Jiang_2011_Bioorg.Med.Chem_19_7228 |
| Author(s) : Jiang H , Wang X , Huang L , Luo Z , Su T , Ding K , Li X |
| Ref : Bioorganic & Medicinal Chemistry , 19 :7228 , 2011 |
| Abstract : Jiang_2011_Bioorg.Med.Chem_19_7228 |
| ESTHER : Jiang_2011_Bioorg.Med.Chem_19_7228 |
| PubMedSearch : Jiang_2011_Bioorg.Med.Chem_19_7228 |
| PubMedID: 22041172 |
| Title : Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-beta aggregation - Shan_2011_Eur.J.Med.Chem_46_5885 |
| Author(s) : Shan WJ , Huang L , Zhou Q , Meng FC , Li XS |
| Ref : Eur Journal of Medicinal Chemistry , 46 :5885 , 2011 |
| Abstract : Shan_2011_Eur.J.Med.Chem_46_5885 |
| ESTHER : Shan_2011_Eur.J.Med.Chem_46_5885 |
| PubMedSearch : Shan_2011_Eur.J.Med.Chem_46_5885 |
| PubMedID: 22019228 |
| Title : The therapeutic potential of Berberis darwinii stem-bark: quantification of berberine and in vitro evidence for Alzheimer's disease therapy - Habtemariam_2011_Nat.Prod.Commun_6_1089 |
| Author(s) : Habtemariam S |
| Ref : Nat Prod Commun , 6 :1089 , 2011 |
| Abstract : Habtemariam_2011_Nat.Prod.Commun_6_1089 |
| ESTHER : Habtemariam_2011_Nat.Prod.Commun_6_1089 |
| PubMedSearch : Habtemariam_2011_Nat.Prod.Commun_6_1089 |
| PubMedID: 21922905 |
| Title : Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and beta-amyloid aggregation inhibitors - Shi_2011_Bioorg.Med.Chem_19_2298 |
| Author(s) : Shi A , Huang L , Lu C , He F , Li X |
| Ref : Bioorganic & Medicinal Chemistry , 19 :2298 , 2011 |
| Abstract : Shi_2011_Bioorg.Med.Chem_19_2298 |
| ESTHER : Shi_2011_Bioorg.Med.Chem_19_2298 |
| PubMedSearch : Shi_2011_Bioorg.Med.Chem_19_2298 |
| PubMedID: 21397508 |
| Title : A new and weakly antispasmodic protoberberine alkaloid from Rhizoma Coptidis - Zhao_2010_Phytother.Res_24_1414 |
| Author(s) : Zhao M , Xian YF , Ip SP , Fong HH , Che CT |
| Ref : Phytother Res , 24 :1414 , 2010 |
| Abstract : Zhao_2010_Phytother.Res_24_1414 |
| ESTHER : Zhao_2010_Phytother.Res_24_1414 |
| PubMedSearch : Zhao_2010_Phytother.Res_24_1414 |
| PubMedID: 20564546 |
| Title : Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase\/butyrylcholinesterase - Huang_2010_Bioorg.Med.Chem.Lett_20_6649 |
| Author(s) : Huang L , Luo Z , He F , Shi A , Qin F , Li X |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6649 , 2010 |
| Abstract : Huang_2010_Bioorg.Med.Chem.Lett_20_6649 |
| ESTHER : Huang_2010_Bioorg.Med.Chem.Lett_20_6649 |
| PubMedSearch : Huang_2010_Bioorg.Med.Chem.Lett_20_6649 |
| PubMedID: 20880702 |
| Title : Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors - Huang_2010_Bioorg.Med.Chem_18_1244 |
| Author(s) : Huang L , Shi A , He F , Li X |
| Ref : Bioorganic & Medicinal Chemistry , 18 :1244 , 2010 |
| Abstract : Huang_2010_Bioorg.Med.Chem_18_1244 |
| ESTHER : Huang_2010_Bioorg.Med.Chem_18_1244 |
| PubMedSearch : Huang_2010_Bioorg.Med.Chem_18_1244 |
| PubMedID: 20056426 |
| Title : Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase - Huang_2010_Bioorg.Med.Chem_18_4475 |
| Author(s) : Huang L , Luo Z , He F , Lu J , Li X |
| Ref : Bioorganic & Medicinal Chemistry , 18 :4475 , 2010 |
| Abstract : Huang_2010_Bioorg.Med.Chem_18_4475 |
| ESTHER : Huang_2010_Bioorg.Med.Chem_18_4475 |
| PubMedSearch : Huang_2010_Bioorg.Med.Chem_18_4475 |
| PubMedID: 20471843 |
| Title : Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies - Yu_2010_Biochem.Pharmacol_79_1000 |
| Author(s) : Yu Y , Liu L , Wang X , Liu X , Xie L , Wang G |
| Ref : Biochemical Pharmacology , 79 :1000 , 2010 |
| Abstract : Yu_2010_Biochem.Pharmacol_79_1000 |
| ESTHER : Yu_2010_Biochem.Pharmacol_79_1000 |
| PubMedSearch : Yu_2010_Biochem.Pharmacol_79_1000 |
| PubMedID: 19945441 |
| Title : Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease - Zhang_2009_Saudi.Med.J_30_760 |
| Author(s) : Zhang J , Yang JQ , He BC , Zhou QX , Yu HR , Tang Y , Liu BZ |
| Ref : Saudi Med J , 30 :760 , 2009 |
| Abstract : Zhang_2009_Saudi.Med.J_30_760 |
| ESTHER : Zhang_2009_Saudi.Med.J_30_760 |
| PubMedSearch : Zhang_2009_Saudi.Med.J_30_760 |
| PubMedID: 19526156 |
| Title : The natural product berberine is a human prolyl oligopeptidase inhibitor - Tarrago_2007_ChemMedChem_2_354 |
| Author(s) : Tarrago T , Kichik N , Segui J , Giralt E |
| Ref : ChemMedChem , 2 :354 , 2007 |
| Abstract : Tarrago_2007_ChemMedChem_2_354 |
| ESTHER : Tarrago_2007_ChemMedChem_2_354 |
| PubMedSearch : Tarrago_2007_ChemMedChem_2_354 |
| PubMedID: 17295371 |
| Title : Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids - Shigeta_2002_Biosci.Biotechnol.Biochem_66_2491 |
| Author(s) : Shigeta K , Ootaki K , Tatemoto H , Nakanishi T , Inada A , Muto N |
| Ref : Biosci Biotechnol Biochem , 66 :2491 , 2002 |
| Abstract : Shigeta_2002_Biosci.Biotechnol.Biochem_66_2491 |
| ESTHER : Shigeta_2002_Biosci.Biotechnol.Biochem_66_2491 |
| PubMedSearch : Shigeta_2002_Biosci.Biotechnol.Biochem_66_2491 |
| PubMedID: 12506995 |
| Title : Effect of long-term administration of berberine on scopolamine-induced amnesia in rats - Peng_1997_Jpn.J.Pharmacol_74_261 |
| Author(s) : Peng WH , Hsieh MT , Wu CR |
| Ref : Japanese Journal of Pharmacology , 74 :261 , 1997 |
| Abstract : Peng_1997_Jpn.J.Pharmacol_74_261 |
| ESTHER : Peng_1997_Jpn.J.Pharmacol_74_261 |
| PubMedSearch : Peng_1997_Jpn.J.Pharmacol_74_261 |
| PubMedID: 9268086 |
| Title : Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores - Schmeller_1997_Phytochemistry_44_257 |
| Author(s) : Schmeller T , Latz-Bruning B , Wink M |
| Ref : Phytochemistry , 44 :257 , 1997 |
| Abstract : Schmeller_1997_Phytochemistry_44_257 |
| ESTHER : Schmeller_1997_Phytochemistry_44_257 |
| PubMedSearch : Schmeller_1997_Phytochemistry_44_257 |
| PubMedID: 9004542 |
| Title : A paradoxical stimulatory effect of berberine on guinea-pig ileum contractility: possible involvement of acetylcholine release from the postganglionic parasympathetic nerve and cholinesterase inhibition - Shin_1993_Life.Sci_53_1495 |
| Author(s) : Shin DH , Yu H , Hsu WH |
| Ref : Life Sciences , 53 :1495 , 1993 |
| Abstract : Shin_1993_Life.Sci_53_1495 |
| ESTHER : Shin_1993_Life.Sci_53_1495 |
| PubMedSearch : Shin_1993_Life.Sci_53_1495 |
| PubMedID: 8412513 |
| Title : Pharmacological effects of berberine on the longitudinal muscle of the guinea-pig isolated ileum - Tsai_1991_Arch.Int.Pharmacodyn.Ther_310_116 |
| Author(s) : Tsai CS , Ochillo RF |
| Ref : Archives Internationales de Pharmacodynamie et de Therapie , 310 :116 , 1991 |
| Abstract : Tsai_1991_Arch.Int.Pharmacodyn.Ther_310_116 |
| ESTHER : Tsai_1991_Arch.Int.Pharmacodyn.Ther_310_116 |
| PubMedSearch : Tsai_1991_Arch.Int.Pharmacodyn.Ther_310_116 |
| PubMedID: 1772324 |