Bisnorcymserine
PEC (-)-N1-phenethylnorcymserine; BNC (-)-N1,n8-bisnorcymserine . BChE selectivity versus AChE (IC50 ratios) human: Cymserine 15-fold, PEC >5000-fold, BNC 110-fold; rat Cymserine 21-fold, PEC >3300-fold, BNC 150-fold
General
Type : Carbamate,Indole,Derivative of physostigmine-eserine
Chemical_Nomenclature : [(3aR,8bS)-8b-methyl-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-b]indol-7-yl] N-(4-propan-2-ylphenyl)carbamate
Canonical SMILES : CC(C)C1=CC=C(C=C1)NC(=O)OC2=CC3=C(C=C2)NC4C3(CCN4)C
InChI : InChI=1S\/C21H25N3O2\/c1-13(2)14-4-6-15(7-5-14)23-20(25)26-16-8-9-18-17(12-16)21(3)10-11-22-19(21)24-18\/h4-9,12-13,19,22,24H,10-11H2,1-3H3,(H,23,25)\/t19-,21+\/m1\/s1
InChIKey : ZIGIADNCAWZUAB-CTNGQTDRSA-N
Other name(s) : UNII-LXI28K87U3,LXI28K87U3,(-)-Bisnorcymserine,Carbamic acid, N-(4-(1-methylethyl)phenyl)-,(3aS,8aR)-1,2,3,3a,8,8a-hexahydro-3a-methylpyrrolo(2,3-b)indol-5-yl ester
MW : 351.45
Formula : C21H25N3O2
CAS_number : 219920-81-7
PubChem : 71587645
UniChem : ZIGIADNCAWZUAB-CTNGQTDRSA-N
IUPHAR :
Wikipedia :
Target
Families : Bisnorcymserine ligand of proteins in family: BCHE || ACHE
Stucture : 3ZV7 Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine. Crystal Structure of the Complex with its Leaving Group
Protein : torca-ACHE
References (2)
| Title : Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group - Bartolucci_2012_Biochem.J_444_269 |
| Author(s) : Bartolucci C , Stojan J , Yu QS , Greig NH , Lamba D |
| Ref : Biochemical Journal , 444 :269 , 2012 |
| Abstract : Bartolucci_2012_Biochem.J_444_269 |
| ESTHER : Bartolucci_2012_Biochem.J_444_269 |
| PubMedSearch : Bartolucci_2012_Biochem.J_444_269 |
| PubMedID: 22390827 |
| Gene_locus related to this paper: torma-ACHE |
| Title : Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine - Kamal_2006_J.Alzheimers.Dis_10_43 |
| Author(s) : Kamal MA , Klein P , Yu QS , Tweedie D , Li Y , Holloway HW , Greig NH |
| Ref : J Alzheimers Dis , 10 :43 , 2006 |
| Abstract : Kamal_2006_J.Alzheimers.Dis_10_43 |
| ESTHER : Kamal_2006_J.Alzheimers.Dis_10_43 |
| PubMedSearch : Kamal_2006_J.Alzheimers.Dis_10_43 |
| PubMedID: 16988481 |