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Inhibitor Report for: CHEMBL238787

inhibitor of Hormone-sensitive_lipase_like (Ebdrup et al. 2007) but also CES1 and ABHD6 (Iglesias et al. 2016)


General
Type Trifluoro, Carbamate, Piperidine
Chemical_Nomenclature [4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl] 4-(hydroxymethyl)piperidine-1-carboxylate
Canonical SMILES C1CN(CCC1CO)C(=O)OC2=CC=C(C=C2)OC3=NC=C(C=C3)C(F)(F)F
InChI InChI=1S/C19H19F3N2O4/c20-19(21,22)14-1-6-17(23-11-14)27-15-2-4-16(5-3-15)28-18(26)24-9-7-13(12-25)8-10-24/h1-6,11,13,25H,7-10,12H2
InChIKey SEUFQIJDZTWDLJ-UHFFFAOYSA-N
Other name(s) compound 13f ; SCHEMBL5650843 ; SEUFQIJDZTWDLJ-UHFFFAOYSA-N ; BDBM50224169 ; 4-Hydroxymethyl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester ; 4-hydroxymethyl-piperidine-1-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester
________________________________________________________________________________________________
MW|396.36
Formula|C19H19F3N2O4
CAS_number|
PubChem|23636024
UniChem|SEUFQIJDZTWDLJ-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | CHEMBL238787 ligand of proteins in family: Hormone-sensitive_lipase_like, Carb_B_Chordata, ABHD6-Lip

References:
Search PubMed for references concerning: CHEMBL238787
    Title: Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors
    Iglesias J, Lamontagne J, Erb H, Gezzar S, Zhao S, Joly E, Truong VL, Skorey K, Crane S and Prentki M <1 more author(s)>
    Ref: J Lipid Res, 57:131, 2016 : PubMed

            

    Title: Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects
    Ebdrup S, Refsgaard HH, Fledelius C, Jacobsen P
    Ref: Journal of Medicinal Chemistry, 50:5449, 2007 : PubMed