CHEMBL4069230
General
Type : Sulfur Compound,Naphthalen
Chemical_Nomenclature : N-[4-[(4-naphthalen-2-yloxyphenyl)sulfamoyl]phenyl]acetamide
Canonical SMILES : CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)OC3=CC4=CC=CC=C4C=C3
InChI : InChI=1S\/C24H20N2O4S\/c1-17(27)25-20-9-14-24(15-10-20)31(28,29)26-21-7-12-22(13-8-21)30-23-11-6-18-4-2-3-5-19(18)16-23\/h2-16,26H,1H3,(H,25,27)
InChIKey : YYGHDFIKAKVWFF-UHFFFAOYSA-N
Other name(s) : 8U0,AC1LOBCX,ZINC991941,STK256902
MW : 432.5
Formula : C24H20N2O4S
CAS_number :
PubChem : 1217803
UniChem : YYGHDFIKAKVWFF-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : CHEMBL4069230 ligand of proteins in family: PAF-Acetylhydrolase
Stucture : 5YE7 The crystal structure of human Lp-PLA2 in complex with a novel inhibitor
Protein : human-PLA2G7
References (1)
| Title : Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2 - Liu_2017_J.Med.Chem_60_10231 |
| Author(s) : Liu Q , Huang F , Yuan X , Wang K , Zou Y , Shen J , Xu Y |
| Ref : Journal of Medicinal Chemistry , 60 :10231 , 2017 |
| Abstract : Liu_2017_J.Med.Chem_60_10231 |
| ESTHER : Liu_2017_J.Med.Chem_60_10231 |
| PubMedSearch : Liu_2017_J.Med.Chem_60_10231 |
| PubMedID: 29193967 |
| Gene_locus related to this paper: human-PLA2G7 |