CID155803782
ABHD17B IC50 0.96(0.8-1.2)microM LYPLA1 IC50 0.45(0.38-0.52)microM
General
Type : Piperazine,Trifluoro,Sulfur Compound,Sulfonamide,Morpholine,Pyrazole
Chemical_Nomenclature : N,N-dimethyl-1-[4-[[2-morpholin-4-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbonyl]pyrazole-4-sulfonamide
Canonical SMILES : CN(C)S(=O)(=O)C1=CN(N=C1)C(=O)N2CCN(CC2)CC3=C(C=C(C=C3)C(F)(F)F)N4CCOCC4
InChI : InChI=1S\/C22H29F3N6O4S\/c1-27(2)36(33,34)19-14-26-31(16-19)21(32)30-7-5-28(6-8-30)15-17-3-4-18(22(23,24)25)13-20(17)29-9-11-35-12-10-29\/h3-4,13-14,16H,5-12,15H2,1-2H3
InChIKey : KJPLRPCRGIUKDJ-UHFFFAOYSA-N
Other name(s) : Compound 2 Remsberg et al.
MW : 530.6
Formula : C22H29F3N6O4S
CAS_number :
PubChem : 155803782
UniChem : KJPLRPCRGIUKDJ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : CID155803782 ligand of proteins in family: ABHD17-depalmitoylase || LYsophospholipase_carboxylesterase
Stucture :
Protein : human-ABHD17B || human-LYPLA1
References (1)
| Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
| Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
| Ref : Nat Chemical Biology , : , 2021 |
| Abstract : Remsberg_2021_Nat.Chem.Biol__ |
| ESTHER : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedID: 33927411 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |