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Inhibitor Report for: CID155803786

ABHD17B IC50 0.13(0.11-0.16) microM ; LYPLA1 IC50 >10 microM


General
Type Piperazine, Trifluoro, Sulfur Compound, Sulfonamide, Morpholine, Pyrazole
Chemical_Nomenclature N,N-dimethyl-1-[(2S)-2-methyl-4-[[2-morpholin-4-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbonyl]pyrazole-3-sulfonamide
Canonical SMILES CC1CN(CCN1C(=O)N2C=CC(=N2)S(=O)(=O)N(C)C)CC3=C(C=C(C=C3)C(F)(F)F)N4CCOCC4
InChI InChI=1S/C23H31F3N6O4S/c1-17-15-29(8-9-31(17)22(33)32-7-6-21(27-32)37(34,35)28(2)3)16-18-4-5-19(23(24,25)26)14-20(18)30-10-12-36-13-11-30/h4-7,14,17H,8-13,15-16H2,1-3H3/t17-/m0/s1
InChIKey GZLDKPLEYSQAJD-KRWDZBQOSA-N
Other name(s) Compound 4 Remsberg et al.
________________________________________________________________________________________________
MW|544.6
Formula|C23H31F3N6O4S
CAS_number|
PubChem|155803786
UniChem|GZLDKPLEYSQAJD-KRWDZBQOSA-N
IUPHAR|
Wikipedia|

Target
Families | CID155803786 ligand of proteins in family: ABHD17-depalmitoylase
Protein | human-ABHD17B

References:
Search PubMed for references concerning: CID155803786
    Title: ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
    Remsberg JR, Suciu RM, Zambetti NA, Hanigan TW, Firestone AJ, Inguva A, Long A, Ngo N, Lum KM and Cravatt BF <8 more author(s)>
    Ref: Nat Chemical Biology, :, 2021 : PubMed