PEC (-)-N1-phenethylnorcymserine; BNC (-)-N1,n8-bisnorcymserine . BChE selectivity versus AChE (IC50 ratios) human: Cymserine 15-fold, PEC >5000-fold, BNC 110-fold; rat Cymserine 21-fold, PEC >3300-fold, BNC 150-fold
Type : Derivative of physostigmine-eserine,Carbamate,Indole
Chemical_Nomenclature : [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-(4-propan-2-ylphenyl)carbamate
Canonical SMILES : CC(C)C1=CC=C(C=C1)NC(=O)OC2=CC3=C(C=C2)N(C4C3(CCN4C)C)C
InChI : InChI=1S\/C23H29N3O2\/c1-15(2)16-6-8-17(9-7-16)24-22(27)28-18-10-11-20-19(14-18)23(3)12-13-25(4)21(23)26(20)5\/h6-11,14-15,21H,12-13H2,1-5H3,(H,24,27)\/t21-,23+\/m1\/s1
InChIKey : NKJRRVBTMYRXRB-GGAORHGYSA-N
Other name(s) : 4-isopropylphenyserine,Cymserine.tartaric acid,D00VSE,D0O2OH
MW : 379.50
Formula : C23H29N3O2
CAS_number : 145209-39-8
PubChem : 9907847
UniChem : NKJRRVBTMYRXRB-GGAORHGYSA-N
IUPHAR :
Wikipedia : Cymserine
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Author(s) : Kamal MA , Shakil S , Nawaz MS , Yu QS , Tweedie D , Tan Y , Qu X , Greig NH |
Ref : CNS Neurol Disord Drug Targets , 16 :820 , 2017 |
Abstract : Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
ESTHER : Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
PubMedSearch : Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
PubMedID: 28176640 |
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Author(s) : Bartolucci C , Stojan J , Yu QS , Greig NH , Lamba D |
Ref : Biochemical Journal , 444 :269 , 2012 |
Abstract : Bartolucci_2012_Biochem.J_444_269 |
ESTHER : Bartolucci_2012_Biochem.J_444_269 |
PubMedSearch : Bartolucci_2012_Biochem.J_444_269 |
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Gene_locus related to this paper: torma-ACHE |
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Author(s) : Greig NH , Utsuki T , Ingram DK , Wang Y , Pepeu G , Scali C , Yu QS , Mamczarz J , Holloway HW , Giordano T , Chen D , Furukawa K , Sambamurti K , Brossi A , Lahiri DK |
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Ref : Acta Neurologica Scandinavica Supplementum , 176 :60 , 2000 |
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