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Inhibitor Report for: DEP-4PAM

Reactivators of organophosphate-inhibited ChEs give rise to instable phosphorylated oximes that reinhibit the enzyme


General
Type Organophosphate, Phosphonylated oxime
Chemical_Nomenclature diethyl[(1-methylpyridin-1-ium-4-yl)methylideneamino] phosphate
Canonical SMILES CCOP(=O)(OCC)ON=CC1=CC=[N+](C=C1)C
InChI InChI=1S/C11H18N2O4P/c1-4-15-18(14,16-5-2)17-12-10-11-6-8-13(3)9-7-11/h6-10H,4-5H2,1-3H3/q+1
InChIKey OABNVZQRFUXBEL-UHFFFAOYSA-N
Other name(s) 1-methyl-4 pyridinium carboxaldehyde oxime ; diethylphosphoryl-4PAM
________________________________________________________________________________________________
MW|273.25
Formula|C11H18N2O4P+
CAS_number|
PubChem|85102394
UniChem|OABNVZQRFUXBEL-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | DEP-4PAM ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: DEP-4PAM
    Title: Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases
    Leader H, Vincze A, Manisterski B, Rothschild N, Dosoretz C, Ashani Y
    Ref: Biochemical Pharmacology, 58:503, 1999 : PubMed