Reactivators of organophosphate-inhibited ChEs give rise to phosphorylated oximes that reinhibit the enzyme. Reactivation of AChE inhibited by MEPQ with Lu6(Toxogonin) will give EMP-Lu6(Toxogonin)
Type : Organophosphate,Phosphonylated oxime
Chemical_Nomenclature : ethoxyl methylphosphonyl-Toxogonin
Canonical SMILES : CCO[P](=O)(C)CN=CC1=CC=[N+](C=C1)COCN2C=CC(=C[N+]([H])=O)C=C2
InChI : InChI=1S\/C18H24N4O4P\/c1-3-26-27(2,24)14-19-12-17-4-8-21(9-5-17)15-25-16-22-10-6-18(7-11-22)13-20-23\/h4-13H,3,14-16H2,1-2H3\/q+1\/p+1
InChIKey : UOFGEYVWWJZAKO-UHFFFAOYSA-O
Other name(s) : EMP-Lu6,EMP-LuH6,ethoxy methyl phosphonyl toxogonin
MW : 463.29
Formula : C18H25Cl2N4O4P
CAS_number :
PubChem :
UniChem : UOFGEYVWWJZAKO-UHFFFAOYSA-O
IUPHAR :
Wikipedia :
Title : Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium - Luo_1999_Biochemistry_38_9937 |
Author(s) : Luo C , Saxena A , Smith M , Garcia GE , Radic Z , Taylor P , Doctor BP |
Ref : Biochemistry , 38 :9937 , 1999 |
Abstract : Luo_1999_Biochemistry_38_9937 |
ESTHER : Luo_1999_Biochemistry_38_9937 |
PubMedSearch : Luo_1999_Biochemistry_38_9937 |
PubMedID: 10433700 |