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Inhibitor Report for: Fragment-924

Not inhibitor of Notum. Compound 55 Fragment 924 IC50 200+/-76 microM


General
Type Fragment inhibitor of Notum
Chemical_Nomenclature (2R)-2-(4-phenylphenoxy)propanoic acid
Canonical SMILES CC(C(=O)O)OC1=CC=C(C=C1)C2=CC=CC=C2
InChI InChI=1S/C15H14O3/c1-11(15(16)17)18-14-9-7-13(8-10-14)12-5-3-2-4-6-12/h2-11H,1H3,(H,16,17)/t11-/m1/s1
InChIKey FUPGQEMJIGUBGO-LLVKDONJSA-N
Other name(s) Fragment 924 ; Compound 55 ; TE8 ; (2~{R})-2-(4-phenylphenoxy)propanoic acid ; SCHEMBL7978298 ; ZINC241544 ; (R)-2-[(Biphenyl-4-yl)oxy]propanoic acid
________________________________________________________________________________________________
MW|242.27
Formula|C15H14O3
CAS_number|
PubChem|765737
UniChem|FUPGQEMJIGUBGO-LLVKDONJSA-N
IUPHAR|
Wikipedia|

Target
Families | Fragment-924 ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 7BDD: Structure of the human Wnt deacylase Notum in complex with fragment 924
Protein | human-NOTUM

References:
Search PubMed for references concerning: Fragment-924
    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed