Fulvestrant
Fulvestrant is a synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells
General
Type : Trifluoro,Sulfur Compound,Drug,Not A\/B H target,Phenanthrene
Chemical_Nomenclature : (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Canonical SMILES : CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
InChI : InChI=1S\/C32H47F5O3S\/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37\/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3\/t22-,26-,27+,28+,29-,30+,41?\/m1\/s1
InChIKey : VWUXBMIQPBEWFH-WCCTWKNTSA-N
Other name(s) : FVS,Faslodex,ICI 182,780,Ici 182780,ICI-182780
MW : 606.77
Formula : C32H47F5O3S
CAS_number : 129453-61-8
PubChem : 104741
UniChem : VWUXBMIQPBEWFH-WCCTWKNTSA-N
IUPHAR :
Wikipedia :
Target
Families : Fulvestrant ligand of proteins in family: Epoxide_hydrolase
Stucture : 4J03 Crystal structure of human soluble human epoxide hydrolase complexed with fulvestrant.
Protein : human-EPHX2
References (1)
| Title : Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides - Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818 |
| Author(s) : Morisseau C , Pakhomova S , Hwang SH , Newcomer ME , Hammock BD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :3818 , 2013 |
| Abstract : Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818 |
| ESTHER : Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818 |
| PubMedSearch : Morisseau_2013_Bioorg.Med.Chem.Lett_23_3818 |
| PubMedID: 23684894 |
| Gene_locus related to this paper: human-EPHX2 |