JF635
Azetidine-substituted fluorescent compound ligand of Halo-Tag. Si-rhodamine JF635 JF635-HaloTag ligand
General
Type : Fluorescent Probe,HaloTag-ligand,Azetidin,Carboxamide,Benzofuran
Chemical_Nomenclature : N-[2-[2-(6-chlorohexoxy)ethoxy]ethyl]-3',7'-bis(3-fluoroazetidin-1-yl)-5',5'-dimethyl-1-oxospiro[2-benzofuran-3,10'-benzo[b][1]benzosiline]-5-carboxamide
Canonical SMILES : C[Si]1(C2=C(C=CC(=C2)N3CC(C3)F)C4(C5=C1C=C(C=C5)N6CC(C6)F)C7=C(C=CC(=C7)C(=O)NCCOCCOCCCCCCCl)C(=O)O4)C
InChI : InChI=1S\/C39H46ClF2N3O5Si\/c1-51(2)35-20-29(44-22-27(41)23-44)8-11-32(35)39(33-12-9-30(21-36(33)51)45-24-28(42)25-45)34-19-26(7-10-31(34)38(47)50-39)37(46)43-14-16-49-18-17-48-15-6-4-3-5-13-40\/h7-12,19-21,27-28H,3-6,13-18,22-25H2,1-2H3,(H,43,46)
InChIKey : FWPLRLFVYPWZHQ-UHFFFAOYSA-N
Other name(s) : PUJ,Janelia Fluor 635
MW : 738.3
Formula : C39H46ClF2N3O5Si
CAS_number :
PubChem : 147582007
UniChem : FWPLRLFVYPWZHQ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : JF635 ligand of proteins in family: Haloalkane_dehalogenase-HLD2
Stucture : 6U2M Crystal structure of a HaloTag-based calcium indicator, HaloCaMP V2, bound to JF635
Protein : rhoso-halo1
References (2)
| Title : The HaloTag as a general scaffold for far-red tunable chemigenetic indicators - Deo_2021_Nat.Chem.Biol_17_718 |
| Author(s) : Deo C , Abdelfattah AS , Bhargava HK , Berro AJ , Falco N , Farrants H , Moeyaert B , Chupanova M , Lavis LD , Schreiter ER |
| Ref : Nat Chemical Biology , 17 :718 , 2021 |
| Abstract : Deo_2021_Nat.Chem.Biol_17_718 |
| ESTHER : Deo_2021_Nat.Chem.Biol_17_718 |
| PubMedSearch : Deo_2021_Nat.Chem.Biol_17_718 |
| PubMedID: 33795886 |
| Gene_locus related to this paper: rhoso-halo1 |
| Title : Accurate measurement of fast endocytic recycling kinetics in real time - Jonker_2020_J.Cell.Sci_133_ |
| Author(s) : Jonker CTH , Deo C , Zager PJ , Tkachuk AN , Weinstein AM , Rodriguez-Boulan E , Lavis LD , Schreiner R |
| Ref : Journal of Cell Science , 133 : , 2020 |
| Abstract : Jonker_2020_J.Cell.Sci_133_ |
| ESTHER : Jonker_2020_J.Cell.Sci_133_ |
| PubMedSearch : Jonker_2020_J.Cell.Sci_133_ |
| PubMedID: 31843759 |
| Gene_locus related to this paper: rhoso-halo1 |