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Inhibitor Report for: KC01

IC50 value of KC01 is 90 +/- 20 nM for ABHD16A


General
Type Oxooxetan
Chemical_Nomenclature (6Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide
Canonical SMILES CCCCCCCCCCCCCC1C(=CCCCCC(=O)N)C(=O)O1
InChI InChI=1S/C22H39NO3/c1-2-3-4-5-6-7-8-9-10-11-14-17-20-19(22(25)26-20)16-13-12-15-18-21(23)24/h16,20H,2-15,17-18H2,1H3,(H2,23,24)/b19-16-
InChIKey RJBBAPPWVJEOMC-MNDPQUGUSA-N
Other name(s) (Z)-6-(2-Oxo-4-tridecyloxetan-3-ylidene)hexanamide ; CHEMBL4525638 ; SCHEMBL17760784 ; SCHEMBL17760785 ; BDBM195603
________________________________________________________________________________________________
MW|365.5
Formula|C22H39NO3
CAS_number|1646795-59-6
PubChem|86289046
UniChem|RJBBAPPWVJEOMC-MNDPQUGUSA-N
IUPHAR|
Wikipedia|

Target
Families | KC01 ligand of proteins in family: Cholesterol_esterase, ABHD16
Protein | human-ABHD16A, human-ABHD12, mouse-Abhd16a

References:
Search PubMed for references concerning: KC01
    Title: Increase in Cellular Lysophosphatidylserine Content Exacerbates Inflammatory Responses in LPS-Activated Microglia
    Minamihata T, Takano K, Nakamura Y, Seto R, Moriyama M
    Ref: Neurochem Res, :, 2021 : PubMed

            

    Title: Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay
    Kamat SS, Camara K, Parsons WH, Chen DH, Dix MM, Bird TD, Howell AR, Cravatt BF
    Ref: Nat Chemical Biology, 11:164, 2015 : PubMed