KK094
KK094 is a potent inhibitor of strigolactone receptors. KK094 inhibited SL-induced formation of the D14-D53 complex. KK094 was hydrolyzed by D14: a reaction product covalently binds to the Ser residue of the catalytic triad of D14. KK094 also inhibited the ShHTL7 receptor, however, with much lower efficiency, and reduced the rate of Striga seed germination
General
Type : Urea derivative,Strigolactone receptors ligand,Triazol,Indole
Chemical_Nomenclature : (2,3-dihydro-1H-indol-1-yl)(1H-1,2,3-triazol-1-yl)methanone
Canonical SMILES : O=C(N1CCc2ccccc12)n1ccnn1
InChI : 1S\/C11H10N4O\/c16-11(15-8-6-12-13-15)14-7-5-9-3-1-2-4-10(9)14\/h1-4,6,8H,5,7H2
InChIKey : YHDLKWQIQYNPEK-UHFFFAOYSA-N
Other name(s) : KOK,2,3-dihydroindol-1-yl(1,2,3-triazol-1-yl)methanone
MW : 214.22
Formula : C11H10N4O
CAS_number :
PubChem : 137349652
UniChem : YHDLKWQIQYNPEK-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : KK094 ligand of proteins in family: RsbQ-like
Stucture : 5ZHR Crystal structure of OsD14 in complex with covalently bound KK094
Protein : orysj-Q10QA5 || strhe-ShHTL7
References (2)
| Title : Rational design of Striga hermonthica-specific seed germination inhibitors - Zarban_2022_Plant.Physiol_188_1369 |
| Author(s) : Zarban RA , Hameed UFS , Jamil M , Ota T , Wang JY , Arold ST , Asami T , Al-Babili S |
| Ref : Plant Physiol , 188 :1369 , 2022 |
| Abstract : Zarban_2022_Plant.Physiol_188_1369 |
| ESTHER : Zarban_2022_Plant.Physiol_188_1369 |
| PubMedSearch : Zarban_2022_Plant.Physiol_188_1369 |
| PubMedID: 34850204 |
| Gene_locus related to this paper: strhe-ShHTL7 |
| Title : Triazole Ureas Covalently Bind to Strigolactone Receptor and Antagonize Strigolactone Responses - Nakamura_2019_Mol.Plant_12_44 |
| Author(s) : Nakamura H , Hirabayashi K , Miyakawa T , Kikuzato K , Hu W , Xu Y , Jiang K , Takahashi I , Niiyama R , Dohmae N , Tanokura M , Asami T |
| Ref : Mol Plant , 12 :44 , 2019 |
| Abstract : Nakamura_2019_Mol.Plant_12_44 |
| ESTHER : Nakamura_2019_Mol.Plant_12_44 |
| PubMedSearch : Nakamura_2019_Mol.Plant_12_44 |
| PubMedID: 30391752 |
| Gene_locus related to this paper: orysj-Q10QA5 |