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LASSBio-767

derived from the natural piperidine alkaloid (-)-spectaline, obtained from the flowers of Senna spectabilis (Fabaceae)

General

Type : Natural,Derivative of Spectaline,Piperidine

Chemical_Nomenclature : [(2R,3R,6S)-2-methyl-6-(13-oxotetradecyl)piperidin-3-yl] acetate

Canonical SMILES : CC1C(CCC(N1)CCCCCCCCCCCCC(=O)C)OC(=O)C

InChI : InChI=1S\/C22H41NO3\/c1-18(24)14-12-10-8-6-4-5-7-9-11-13-15-21-16-17-22(19(2)23-21)26-20(3)25\/h19,21-23H,4-17H2,1-3H3\/t19-,21+,22-\/m1\/s1

InChIKey : LRKWDKCSHJWJST-BAGYTPMASA-N

Other name(s) : (-)-3-O-acetyl-spectaline,CHEMBL251644,D08BPE,(?)-3-O-Acetylspectaline

MW : 367.57

Formula : C22H41NO3

CAS_number :

PubChem : 10474155

UniChem : LRKWDKCSHJWJST-BAGYTPMASA-N

IUPHAR :

Wikipedia :

Target

Families : LASSBio-767 ligand of proteins in family: ACHE

Stucture :

Protein :

References (5)

Title : Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates - Dias Viegas_2018_Eur.J.Med.Chem_147_48
Author(s) : Dias Viegas FP , de Freitas Silva M , Divino da Rocha M , Castelli MR , Riquiel MM , Machado RP , Vaz SM , Simoes de Lima LM , Mancini KC , Marques de Oliveira PC , Morais EP , Gontijo VS , da Silva FMR , D'Alincourt da Fonseca Pecanha D , Castro NG , Neves GA , Giusti-Paiva A , Vilela FC , Orlandi L , Camps I , Veloso MP , Leomil Coelho LF , Ionta M , Ferreira-Silva GA , Pereira RM , Dardenne LE , Guedes IA , de Oliveira Carneiro Junior W , Quaglio Bellozi PM , Pinheiro de Oliveira AC , Ferreira FF , Pruccoli L , Tarozzi A , Viegas C, Jr.
Ref : Eur Journal of Medicinal Chemistry , 147 :48 , 2018
Abstract : Dias Viegas_2018_Eur.J.Med.Chem_147_48
ESTHER : Dias Viegas_2018_Eur.J.Med.Chem_147_48
PubMedSearch : Dias Viegas_2018_Eur.J.Med.Chem_147_48
PubMedID: 29421570

Title : CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline - Castro_2008_Eur.J.Pharmacol_580_339
Author(s) : Castro NG , Costa RS , Pimentel LS , Danuello A , Romeiro NC , Viegas C, Jr. , Barreiro EJ , Fraga CA , Bolzani VS , Rocha MS
Ref : European Journal of Pharmacology , 580 :339 , 2008
Abstract : Castro_2008_Eur.J.Pharmacol_580_339
ESTHER : Castro_2008_Eur.J.Pharmacol_580_339
PubMedSearch : Castro_2008_Eur.J.Pharmacol_580_339
PubMedID: 18096154

Title : New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids - Viegas_2005_Bioorg.Med.Chem_13_4184
Author(s) : Viegas C, Jr. , Bolzani VS , Pimentel LS , Castro NG , Cabral RF , Costa RS , Floyd C , Rocha MS , Young MC , Barreiro EJ , Fraga CA
Ref : Bioorganic & Medicinal Chemistry , 13 :4184 , 2005
Abstract : Viegas_2005_Bioorg.Med.Chem_13_4184
ESTHER : Viegas_2005_Bioorg.Med.Chem_13_4184
PubMedSearch : Viegas_2005_Bioorg.Med.Chem_13_4184
PubMedID: 15878668

Title : New anti-Alzheimer drugs from biodiversity: the role of the natural acetylcholinesterase inhibitors - Viegas_2005_Mini.Rev.Med.Chem_5_915
Author(s) : Viegas C, Jr. , Bolzani Vda S , Barreiro EJ , Fraga CA
Ref : Mini Rev Med Chem , 5 :915 , 2005
Abstract : Viegas_2005_Mini.Rev.Med.Chem_5_915
ESTHER : Viegas_2005_Mini.Rev.Med.Chem_5_915
PubMedSearch : Viegas_2005_Mini.Rev.Med.Chem_5_915
PubMedID: 16250834

Title : Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis - Viegas_2004_J.Nat.Prod_67_908
Author(s) : Viegas C, Jr. , da SBV , Furlan M , Barreiro EJ , Young MC , Tomazela D , Eberlin MN
Ref : Journal of Natural Products , 67 :908 , 2004
Abstract : Viegas_2004_J.Nat.Prod_67_908
ESTHER : Viegas_2004_J.Nat.Prod_67_908
PubMedSearch : Viegas_2004_J.Nat.Prod_67_908
PubMedID: 15165164