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Inhibitor Report for: Leupeptin

Leupeptin is a protease inhibitor produced by actinomycetes, that can inhibit cysteine, serine and threonine peptidases


General
Type Peptide, Natural
Chemical_Nomenclature (2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
Canonical SMILES CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C
InChI InChI=1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/t15-,16-,17-/m0/s1
InChIKey GDBQQVLCIARPGH-ULQDDVLXSA-N
Other name(s) N-acetyl-L-leucyl-L-leucyl-L-argininal ; Leupeptin hemisulfate ; Ac-Leu-Leu-Arg-H ; CHEBI:6426 ; CHEMBL191881 ; Acetyl-L-leucyl-L-leucylargininal ; AC1NR4EG ; C01591 ; NK-381 ; SCHEMBL4669504
________________________________________________________________________________________________
MW|426.55
Formula|C20H38N6O4
CAS_number|24365-47-7
PubChem|72429
UniChem|GDBQQVLCIARPGH-ULQDDVLXSA-N
IUPHAR|
Wikipedia|Leupeptin

Target
Families | Leupeptin ligand of proteins in family: S9N_PREPL_Peptidase_S9

References:
Search PubMed for references concerning: Leupeptin
    Title: Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor
    McLuskey K, Paterson NG, Bland ND, Isaacs NW, Mottram JC
    Ref: Journal of Biological Chemistry, 285:39249, 2010 : PubMed