Lipocrine
General
Type : Multitarget,Derivative of Tacrine,Antioxidant,Sulfur Compound,Alkyl linked bis-ligand
Chemical_Nomenclature : N-[3-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]propyl]-5-(dithiolan-3-yl)pentanamide
Canonical SMILES : C1CCC2=NC3=C(C=CC(=C3)Cl)C(=C2C1)NCCCNC(=O)CCCCC4CCSS4
InChI : InChI=1S\/C24H32ClN3OS2\/c25-17-10-11-20-22(16-17)28-21-8-3-2-7-19(21)24(20)27-14-5-13-26-23(29)9-4-1-6-18-12-15-30-31-18\/h10-11,16,18H,1-9,12-15H2,(H,26,29)(H,27,28)
InChIKey : QVGXTQPZHCDXRZ-UHFFFAOYSA-N
Other name(s) : CHEMBL194823,Rac-Lipocrine,D0F5EJ,Tacrine-lipoic acid hybrid 7,SCHEMBL14341601
MW : 478.11
Formula : C24H32ClN3OS2
CAS_number :
PubChem : 11375002
UniChem : QVGXTQPZHCDXRZ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (3)
| Title : MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond - Bolognesi_2009_Curr.Pharm.Des_15_601 |
| Author(s) : Bolognesi ML , Rosini M , Andrisano V , Bartolini M , Minarini A , Tumiatti V , Melchiorre C |
| Ref : Curr Pharm Des , 15 :601 , 2009 |
| Abstract : Bolognesi_2009_Curr.Pharm.Des_15_601 |
| ESTHER : Bolognesi_2009_Curr.Pharm.Des_15_601 |
| PubMedSearch : Bolognesi_2009_Curr.Pharm.Des_15_601 |
| PubMedID: 19199985 |
| Title : Lipoic acid as a novel treatment for Alzheimer's disease and related dementias - Holmquist_2007_Pharmacol.Ther_113_154 |
| Author(s) : Holmquist L , Stuchbury G , Berbaum K , Muscat S , Young S , Hager K , Engel J , Munch G |
| Ref : Pharmacol Ther , 113 :154 , 2007 |
| Abstract : Holmquist_2007_Pharmacol.Ther_113_154 |
| ESTHER : Holmquist_2007_Pharmacol.Ther_113_154 |
| PubMedSearch : Holmquist_2007_Pharmacol.Ther_113_154 |
| PubMedID: 16989905 |
| Title : Rational approach to discover multipotent anti-Alzheimer drugs - Rosini_2005_J.Med.Chem_48_360 |
| Author(s) : Rosini M , Andrisano V , Bartolini M , Bolognesi ML , Hrelia P , Minarini A , Tarozzi A , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 48 :360 , 2005 |
| Abstract : Rosini_2005_J.Med.Chem_48_360 |
| ESTHER : Rosini_2005_J.Med.Chem_48_360 |
| PubMedSearch : Rosini_2005_J.Med.Chem_48_360 |
| PubMedID: 15658850 |