MAGLi-432
General
Type : Piperazine
Chemical_Nomenclature : [(7R,9aR)-7-(4-chlorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-(2-bromo-3-methoxyphenyl)methanone
Canonical SMILES : COC1=CC=CC(=C1Br)C(=O)N2CCN3CC(CCC3C2)C4=CC=C(C=C4)Cl
InChI : InChI=1S\/C22H24BrClN2O2\/c1-28-20-4-2-3-19(21(20)23)22(27)26-12-11-25-13-16(7-10-18(25)14-26)15-5-8-17(24)9-6-15\/h2-6,8-9,16,18H,7,10-14H2,1H3\/t16-,18+\/m0\/s1
InChIKey : BKTASVDLNMGMFP-FUHWJXTLSA-N
Other name(s) : MAGLi 432,SCHEMBL21121561,HY-150702,CS-0542033,MAGLi432
MW : 463.8
Formula : C22H24BrClN2O2
CAS_number :
PubChem : 138740335
UniChem : BKTASVDLNMGMFP-FUHWJXTLSA-N
IUPHAR :
Wikipedia :
Target
Families : MAGLi-432 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture : 7ZPG Crystal structure of human monoglyceride lipase with ligand MAGLi-432
Protein : human-MGLL || mouse-MGLL
References (2)
| Title : A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature - Kemble_2022_PLoS.One_17_e0268590 |
| Author(s) : Kemble AM , Hornsperger B , Ruf I , Richter H , Benz J , Kuhn B , Heer D , Wittwer M , Engelhardt B , Grether U , Collin L |
| Ref : PLoS ONE , 17 :e0268590 , 2022 |
| Abstract : Kemble_2022_PLoS.One_17_e0268590 |
| ESTHER : Kemble_2022_PLoS.One_17_e0268590 |
| PubMedSearch : Kemble_2022_PLoS.One_17_e0268590 |
| PubMedID: 36084029 |
| Gene_locus related to this paper: human-MGLL |
| Title : Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain - He_2022_Eur.J.Med.Chem_243_114750 |
| Author(s) : He Y , Grether U , Taddio MF , Meier C , Keller C , Edelmann MR , Honer M , Huber S , Wittwer MB , Heer D , Richter H , Collin L , Hug MN , Hilbert M , Postmus AGJ , Stevens AF , van der Stelt M , Kramer SD , Schibli R , Mu L , Gobbi LC |
| Ref : Eur Journal of Medicinal Chemistry , 243 :114750 , 2022 |
| Abstract : He_2022_Eur.J.Med.Chem_243_114750 |
| ESTHER : He_2022_Eur.J.Med.Chem_243_114750 |
| PubMedSearch : He_2022_Eur.J.Med.Chem_243_114750 |
| PubMedID: 36137365 |
| Gene_locus related to this paper: human-MGLL , mouse-MGLL |