Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Mevastatin

Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum Penicillium citinium. Mevastatin was the first statin to enter clinical trials.


General
Type Drug, Natural, Not A/B H target, Naphthalen, Antibiotic
Chemical_Nomenclature [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
Canonical SMILES CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O
InChI InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
InChIKey AJLFOPYRIVGYMJ-INTXDZFKSA-N
Other name(s) Mevastatin ; ML-236B ; Mevastatinum ; Antibiotic ML 236B ; Compactin (penicillium)
________________________________________________________________________________________________
MW|390.51
Formula|C23H34O5
CAS_number|73573-88-3
PubChem|64715
UniChem|AJLFOPYRIVGYMJ-INTXDZFKSA-N
IUPHAR|
Wikipedia|Mevastatin

Target
Families | Mevastatin ligand of proteins in family: Carboxylesterase, Carb_B_Chordata
Stucture | 1 structure: 1YA8: Crystal structure of human liver carboxylesterase in complex with mevastatin
Protein | human-CES1

References:
Search PubMed for references concerning: Mevastatin
    Title: Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil
    Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL and Redinbo MR <1 more author(s)>
    Ref: Journal of Molecular Biology, 352:165, 2005 : PubMed

            

    Title: Mammalian carboxylesterases: from drug targets to protein therapeutics
    Redinbo MR, Potter PM
    Ref: Drug Discov Today, 10:313, 2005 : PubMed