P-Toluenesulfonamide
Building block of cholinesterases multitarget inhibitors (p-tolylsulfonamide moiety binds to the Peripheral Anionic Site) and fluorescent substrate for carboxylesterase (the PTSA targeting the endoplasmic reticulum). Also product of hydrolysis of by polyurethane hydrolysing enzymes
General
Type : Sulfonamide,Sulfur Compound,Benzenesulfonamide
Chemical_Nomenclature : 4-methylbenzenesulfonamide
Canonical SMILES : CC1=CC=C(C=C1)S(=O)(=O)N
InChI : InChI=1S\/C7H9NO2S\/c1-6-2-4-7(5-3-6)11(8,9)10\/h2-5H,1H3,(H2,8,9,10)
InChIKey : LMYRWZFENFIFIT-UHFFFAOYSA-N
Other name(s) : 4-Toluenesulfonamide,Tosylamide,CHEMBL574,CHEBI:34435,SCHEMBL7370,ZINC388056
MW : 171.22
Formula : C7H9NO2S
CAS_number : 70-55-3
PubChem : 6269
UniChem : LMYRWZFENFIFIT-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (5)
| Title : A fast fluorescent probe for tracing endoplasmic reticulum-located carboxylesterase in living cells - Dai_2022_Luminescence__ |
| Author(s) : Dai X , Yu F , Jiang Z , Dong B , Kong X |
| Ref : Luminescence , : , 2022 |
| Abstract : Dai_2022_Luminescence__ |
| ESTHER : Dai_2022_Luminescence__ |
| PubMedSearch : Dai_2022_Luminescence__ |
| PubMedID: 36200455 |
| Title : New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment - Makhaeva_2020_Molecules_25_3915 |
| Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Astakhova TY , Rudakova EV , Proshin AN , Serkov IV , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ |
| Ref : Molecules , 25 :3915 , 2020 |
| Abstract : Makhaeva_2020_Molecules_25_3915 |
| ESTHER : Makhaeva_2020_Molecules_25_3915 |
| PubMedSearch : Makhaeva_2020_Molecules_25_3915 |
| PubMedID: 32867324 |
| Title : Endoplasmic Reticulum Targeting Ratiometric Fluorescent Probe for Carboxylesterase 2 Detection in Drug-Induced Acute Liver Injury - Tian_2019_Anal.Chem_91_15840 |
| Author(s) : Tian X , Yan F , Zheng J , Cui X , Feng L , Li S , Jin L , James TD , Ma X |
| Ref : Analytical Chemistry , 91 :15840 , 2019 |
| Abstract : Tian_2019_Anal.Chem_91_15840 |
| ESTHER : Tian_2019_Anal.Chem_91_15840 |
| PubMedSearch : Tian_2019_Anal.Chem_91_15840 |
| PubMedID: 31713417 |
| Gene_locus related to this paper: human-CES2 |
| Title : Enzymatic recycling of thermoplastic polyurethanes: Synergistic effect of an esterase and an amidase and recovery of building blocks - Magnin_2019_Waste.Manag_85_141 |
| Author(s) : Magnin A , Pollet E , Perrin R , Ullmann C , Persillon C , Phalip V , Averous L |
| Ref : Waste Manag , 85 :141 , 2019 |
| Abstract : Magnin_2019_Waste.Manag_85_141 |
| ESTHER : Magnin_2019_Waste.Manag_85_141 |
| PubMedSearch : Magnin_2019_Waste.Manag_85_141 |
| PubMedID: 30803567 |
| Title : Conjugates of Tacrine and Its Cyclic Homologues with p-Toluenesulfonamide as Novel Acetylcholinesterase and Butyrylcholinesterase Inhibitors - Makhaeva_2018_Dokl.Biochem.Biophys_483_369 |
| Author(s) : Makhaeva GF , Kovaleva NV , Lushchekina SV , Rudakova EV , Boltneva NP , Proshin AN , Lednev BV , Serkov IV , Bachurin SO |
| Ref : Dokl Biochem Biophys , 483 :369 , 2018 |
| Abstract : Makhaeva_2018_Dokl.Biochem.Biophys_483_369 |
| ESTHER : Makhaeva_2018_Dokl.Biochem.Biophys_483_369 |
| PubMedSearch : Makhaeva_2018_Dokl.Biochem.Biophys_483_369 |
| PubMedID: 30607741 |