PTUPB
COX-2/sEH dual inhibition. dual cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH) inhibitor
General
Type : Multitarget,Trifluoro,Urea derivative,Sulfur Compound,Sulfonamide,Pyrazole
Chemical_Nomenclature : 1-[3-[5-phenyl-1-(4-sulfamoylphenyl)pyrazol-3-yl]propyl]-3-[4-(trifluoromethyl)phenyl]urea
Canonical SMILES : C1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)CCCNC(=O)NC4=CC=C(C=C4)C(F)(F)F
InChI : InChI=1S\/C26H24F3N5O3S\/c27-26(28,29)19-8-10-20(11-9-19)32-25(35)31-16-4-7-21-17-24(18-5-2-1-3-6-18)34(33-21)22-12-14-23(15-13-22)38(30,36)37\/h1-3,5-6,8-15,17H,4,7,16H2,(H2,30,36,37)(H2,31,32,35)
InChIKey : CSEPEVFNTFMBAE-UHFFFAOYSA-N
Other name(s) : CHEMBL1766287,SCHEMBL9938619
MW : 543.6
Formula : C26H24F3N5O3S
CAS_number : 1287761-01-6
PubChem : 52951990
UniChem : CSEPEVFNTFMBAE-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (12)
| Title : COX-2\/sEH Dual Inhibitor PTUPB Attenuates Epithelial-Mesenchymal Transformation of Alveolar Epithelial Cells via Nrf2-Mediated Inhibition of TGF-beta1\/Smad Signaling - Zhang_2022_Oxid.Med.Cell.Longev_2022_5759626 |
| Author(s) : Zhang CY , Guan XX , Song ZH , Jiang HL , Liu YB , Chen P , Duan JX , Zhou Y |
| Ref : Oxid Med Cell Longev , 2022 :5759626 , 2022 |
| Abstract : Zhang_2022_Oxid.Med.Cell.Longev_2022_5759626 |
| ESTHER : Zhang_2022_Oxid.Med.Cell.Longev_2022_5759626 |
| PubMedSearch : Zhang_2022_Oxid.Med.Cell.Longev_2022_5759626 |
| PubMedID: 35509835 |
| Title : Dual sEH\/COX-2 Inhibition Using PTUPB-A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity - Jankiewicz_2021_Front.Pharmacol_12_744776 |
| Author(s) : Jankiewicz WK , Barnett SD , Stavniichuk A , Hwang SH , Hammock BD , Belayet JB , Khan AH , Imig JD |
| Ref : Front Pharmacol , 12 :744776 , 2021 |
| Abstract : Jankiewicz_2021_Front.Pharmacol_12_744776 |
| ESTHER : Jankiewicz_2021_Front.Pharmacol_12_744776 |
| PubMedSearch : Jankiewicz_2021_Front.Pharmacol_12_744776 |
| PubMedID: 34955823 |
| Title : Multitarget molecule,PTUPB, to treat diabetic nephropathy in rats - Hye_2021_Br.J.Pharmacol_178_4468 |
| Author(s) : Hye Khan MA , Hwang SH , Barnett SD , Stavniichuk A , Jankiewicz WK , Hammock BD , Imig JD |
| Ref : British Journal of Pharmacology , 178 :4468 , 2021 |
| Abstract : Hye_2021_Br.J.Pharmacol_178_4468 |
| ESTHER : Hye_2021_Br.J.Pharmacol_178_4468 |
| PubMedSearch : Hye_2021_Br.J.Pharmacol_178_4468 |
| PubMedID: 34255857 |
| Title : COX-2\/sEH Dual Inhibitor PTUPB Alleviates CCl (4) -Induced Liver Fibrosis and Portal Hypertension - Zhao_2021_Front.Med.(Lausanne)_8_761517 |
| Author(s) : Zhao Z , Zhang C , Lin J , Zheng L , Li H , Qi X , Huo H , Lou X , Hammock BD , Hwang SH , Bao Y , Luo M |
| Ref : Front Med (Lausanne) , 8 :761517 , 2021 |
| Abstract : Zhao_2021_Front.Med.(Lausanne)_8_761517 |
| ESTHER : Zhao_2021_Front.Med.(Lausanne)_8_761517 |
| PubMedSearch : Zhao_2021_Front.Med.(Lausanne)_8_761517 |
| PubMedID: 35004731 |
| Title : PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice - Sun_2020_Biochem.Biophys.Res.Commun__ |
| Author(s) : Sun CC , Zhang CY , Duan JX , Guan XX , Yang HH , Jiang HL , Hammock BD , Hwang SH , Zhou Y , Guan CX , Liu SK , Zhang J |
| Ref : Biochemical & Biophysical Research Communications , : , 2020 |
| Abstract : Sun_2020_Biochem.Biophys.Res.Commun__ |
| ESTHER : Sun_2020_Biochem.Biophys.Res.Commun__ |
| PubMedSearch : Sun_2020_Biochem.Biophys.Res.Commun__ |
| PubMedID: 31973813 |
| Title : A COX-2\/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation - Yang_2020_Theranostics_10_4749 |
| Author(s) : Yang HH , Duan JX , Liu SK , Xiong JB , Guan XX , Zhong WJ , Sun CC , Zhang CY , Luo XQ , Zhang YF , Chen P , Hammock BD , Hwang SH , Jiang JX , Zhou Y , Guan CX |
| Ref : Theranostics , 10 :4749 , 2020 |
| Abstract : Yang_2020_Theranostics_10_4749 |
| ESTHER : Yang_2020_Theranostics_10_4749 |
| PubMedSearch : Yang_2020_Theranostics_10_4749 |
| PubMedID: 32308747 |
| Title : A COX-2\/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress - Zhang_2020_Biomed.Pharmacother_126_109907 |
| Author(s) : Zhang YF , Sun CC , Duan JX , Yang HH , Zhang CY , Xiong JB , Zhong WJ , Zu C , Guan XX , Jiang HL , Hammock BD , Hwang SH , Zhou Y , Guan CX |
| Ref : Biomed Pharmacother , 126 :109907 , 2020 |
| Abstract : Zhang_2020_Biomed.Pharmacother_126_109907 |
| ESTHER : Zhang_2020_Biomed.Pharmacother_126_109907 |
| PubMedSearch : Zhang_2020_Biomed.Pharmacother_126_109907 |
| PubMedID: 32114358 |
| Title : COX-2\/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence - Zhang_2020_FEBS.J_287_1666 |
| Author(s) : Zhang CY , Duan JX , Yang HH , Sun CC , Zhong WJ , Tao JH , Guan XX , Jiang HL , Hammock BD , Hwang SH , Zhou Y , Guan CX |
| Ref : Febs J , 287 :1666 , 2020 |
| Abstract : Zhang_2020_FEBS.J_287_1666 |
| ESTHER : Zhang_2020_FEBS.J_287_1666 |
| PubMedSearch : Zhang_2020_FEBS.J_287_1666 |
| PubMedID: 31646730 |
| Title : Suppression of chemotherapy-induced cytokine\/lipid mediator surge and ovarian cancer by a dual COX-2\/sEH inhibitor - Gartung_2019_Proc.Natl.Acad.Sci.U.S.A_116_1698 |
| Author(s) : Gartung A , Yang J , Sukhatme VP , Bielenberg DR , Fernandes D , Chang J , Schmidt BA , Hwang SH , Zurakowski D , Huang S , Kieran MW , Hammock BD , Panigrahy D |
| Ref : Proc Natl Acad Sci U S A , 116 :1698 , 2019 |
| Abstract : Gartung_2019_Proc.Natl.Acad.Sci.U.S.A_116_1698 |
| ESTHER : Gartung_2019_Proc.Natl.Acad.Sci.U.S.A_116_1698 |
| PubMedSearch : Gartung_2019_Proc.Natl.Acad.Sci.U.S.A_116_1698 |
| PubMedID: 30647111 |
| Title : Effect Of Dual sEH\/COX-2 Inhibition on Allergen-Induced Airway Inflammation - Dileepan_2019_Front.Pharmacol_10_1118 |
| Author(s) : Dileepan M , Rastle-Simpson S , Greenberg Y , Wijesinghe DS , Kumar NG , Yang J , Hwang SH , Hammock BD , Sriramarao P , Rao SP |
| Ref : Front Pharmacol , 10 :1118 , 2019 |
| Abstract : Dileepan_2019_Front.Pharmacol_10_1118 |
| ESTHER : Dileepan_2019_Front.Pharmacol_10_1118 |
| PubMedSearch : Dileepan_2019_Front.Pharmacol_10_1118 |
| PubMedID: 31611798 |
| Title : Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS\/MS method development - Lakkappa_2018_J.Pharm.Biomed.Anal_149_457 |
| Author(s) : Lakkappa N , Krishnamurthy PT , Yamjala K , Hwang SH , Hammock BD , Babu B |
| Ref : J Pharm Biomed Anal , 149 :457 , 2018 |
| Abstract : Lakkappa_2018_J.Pharm.Biomed.Anal_149_457 |
| ESTHER : Lakkappa_2018_J.Pharm.Biomed.Anal_149_457 |
| PubMedSearch : Lakkappa_2018_J.Pharm.Biomed.Anal_149_457 |
| PubMedID: 29169114 |
| Title : COX-2\/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin - Wang_2018_Mol.Cancer.Ther_17_474 |
| Author(s) : Wang F , Zhang H , Ma AH , Yu W , Zimmermann M , Yang J , Hwang SH , Zhu D , Lin TY , Malfatti M , Turteltaub KW , Henderson PT , Airhart S , Hammock BD , Yuan J , de Vere White RW , Pan CX |
| Ref : Mol Cancer Ther , 17 :474 , 2018 |
| Abstract : Wang_2018_Mol.Cancer.Ther_17_474 |
| ESTHER : Wang_2018_Mol.Cancer.Ther_17_474 |
| PubMedSearch : Wang_2018_Mol.Cancer.Ther_17_474 |
| PubMedID: 29284644 |