Phenothiazine
Tricyclic amine-containing compound || Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors. (NCI)
General
Type : Phenothiazine,Not A\/B H target,Multitarget,Drug,Sulfur Compound
Chemical_Nomenclature : Phenothiazine
Canonical SMILES : C1=CC=C2C(=C1)NC3=CC=CC=C3S2
InChI : InChI=1S\/C12H9NS\/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11\/h1-8,13H
InChIKey : WJFKNYWRSNBZNX-UHFFFAOYSA-N
Other name(s) :
MW : 199.3
Formula : C12H9NS
CAS_number : 92-84-2
PubChem : 7108
UniChem : WJFKNYWRSNBZNX-UHFFFAOYSA-N
IUPHAR :
Wikipedia : Phenothiazine
Target
References (1)
| Title : Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase - Singh_1998_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_119_97 |
| Author(s) : Singh AK , Spassova D |
| Ref : Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology , 119 :97 , 1998 |
| Abstract : Singh_1998_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_119_97 |
| ESTHER : Singh_1998_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_119_97 |
| PubMedSearch : Singh_1998_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_119_97 |
| PubMedID: 9568379 |