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Inhibitor Report for: Piperine

Alkaloid isolated from the plant Piper nigrum. It has a role as a NF-kappaB inhibitor, a plant metabolite, a food component and a human blood serum metabolite. Piperine and its isomer chavicine, is the alkaloid responsible for the pungency of black pepper and long pepper


General
Type Fragment inhibitor of Notum, Piperidine, Natural, Benzodioxo
Chemical_Nomenclature (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
Canonical SMILES C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3
InChI InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
InChIKey MXXWOMGUGJBKIW-YPCIICBESA-N
Other name(s) 1-Piperoylpiperidine ; Piperin ; Bioperine
________________________________________________________________________________________________
MW|285.34
Formula|C17H19NO3
CAS_number|94-62-2
PubChem|638024
UniChem|MXXWOMGUGJBKIW-YPCIICBESA-N
IUPHAR|
Wikipedia|Piperine

Target
Families | Piperine ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 7BLW: Human Notum_Piperine complex
Protein | human-NOTUM

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