Propargyl-Tacrine-15
balanced pharmacological profile [IC(50) (hAChE) = 1.472+/-0.024 microM; IC(50) (hBChE) = 0.659+/-0.077 microM; IC(50) (hMAO-B) = 40.39+/-5.98nM]
General
Type : Multitarget,Monoamine-oxidase-inhibitor,Derivative of Tacrine,Alkyne
Chemical_Nomenclature :
Canonical SMILES : [C]1=[C][C]=[C]C(=[C]1)OC2=[C][C]=C3C(=[C]2)C(=C4C(=N3)CCCC4)[N]CC#[C]
InChI : InChI=1S\/C22H20N2O\/c1-2-14-23-22-18-10-6-7-11-20(18)24-21-13-12-17(15-19(21)22)25-16-8-4-3-5-9-16\/h1,3-5,8-9,12-13,15H,6-7,10-11,14H2,(H,23,24)
InChIKey : IBMLQDVOCDHFMT-UHFFFAOYSA-N
Other name(s) :
MW : 328.41
Formula : C22H20N2O
CAS_number :
PubChem :
UniChem : IBMLQDVOCDHFMT-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Propargyl-Tacrine-15 ligand of proteins in family: BCHE || ACHE
Stucture :
Protein : human-BCHE || human-ACHE
References (1)
| Title : Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities - Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| Author(s) : Chrienova Z , Nepovimova E , Andrys R , Dolezal R , Janockova J , Muckova L , Fabova L , Soukup O , Oleksak P , Valis M , Korabecny J , Marco-Contelles J , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 37 :2605 , 2022 |
| Abstract : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| ESTHER : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| PubMedSearch : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| PubMedID: 36131624 |