Quilostigmine
Physostigmine Eserine analogue
General
Type : Derivative of physostigmine-eserine,Carbamate,Isoquinoline,Indole
Chemical_Nomenclature : (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl 3,4-dihydro-2(1H)-isoquinolinecarboxylate
Canonical SMILES : CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)N4CCC5=CC=CC=C5C4)C)C
InChI : InChI=1S\/C23H27N3O2\/c1-23-11-13-24(2)21(23)25(3)20-9-8-18(14-19(20)23)28-22(27)26-12-10-16-6-4-5-7-17(16)15-26\/h4-9,14,21H,10-13,15H2,1-3H3\/t21-,23+\/m1\/s1
InChIKey : IIFRKALDATVOJE-GGAORHGYSA-N
Other name(s) : NXX 066,HP 290,NXX-066
MW : 377.480
Formula : C23H27N3O2
CAS_number : 139314-01-5
PubChem : 132228
UniChem : IIFRKALDATVOJE-GGAORHGYSA-N
IUPHAR :
Wikipedia :
Target
References (3)
| Title : A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066 - Snape_1999_Neuropharmacol_38_181 |
| Author(s) : Snape MF , Misra A , Murray TK , De Souza RJ , Williams JL , Cross AJ , Green AR |
| Ref : Neuropharmacology , 38 :181 , 1999 |
| Abstract : Snape_1999_Neuropharmacol_38_181 |
| ESTHER : Snape_1999_Neuropharmacol_38_181 |
| PubMedSearch : Snape_1999_Neuropharmacol_38_181 |
| PubMedID: 10193909 |
| Title : NXX-066 in patients with Alzheimer's disease: a bridging study - Sramek_1999_Life.Sci_64_1215 |
| Author(s) : Sramek JJ , Hourani J , Jhee SS , Cutler NR |
| Ref : Life Sciences , 64 :1215 , 1999 |
| Abstract : Sramek_1999_Life.Sci_64_1215 |
| ESTHER : Sramek_1999_Life.Sci_64_1215 |
| PubMedSearch : Sramek_1999_Life.Sci_64_1215 |
| PubMedID: 10210264 |
| Title : Detectability improvements in capillary zone electrophoresis by combining single capillary isotachophoretic preconcentration and frequency doubled argon ion laser-induced fluorescence detection - Enlund_1998_Electrophoresis_19_707 |
| Author(s) : Enlund AM , Schmidt S , Westerlund D |
| Ref : Electrophoresis , 19 :707 , 1998 |
| Abstract : Enlund_1998_Electrophoresis_19_707 |
| ESTHER : Enlund_1998_Electrophoresis_19_707 |
| PubMedSearch : Enlund_1998_Electrophoresis_19_707 |
| PubMedID: 9629903 |